Phase 2 Study of Poziotinib in Participants With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation
Public ClinicalTrials.gov record NCT03318939. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Study of Poziotinib in Patients With Non-Small Cell Lung Cancer (NSCLC), Locally Advanced or Metastatic, With EGFR or HER2 Exon 20 Insertion Mutation (ZENITH20)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 2, open-label, multi-center study to evaluate the efficacy and the safety/tolerability of poziotinib in seven participant cohorts for up to 603 previously treated and treatment-naïve NSCLC participant. Cohorts 3 and 4 were added with Amendment 1 and three additional cohorts were added with Amendment 2 (Cohorts 5, 6 and 7).
Study identification
- NCT ID
- NCT03318939
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 648 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 11, 2017 (Actual)
- Primary completion
- Apr 3, 2023 (Actual)
- Completion
- Apr 3, 2023 (Actual)
- Last update posted
- Jun 12, 2026
2017 – 2023
United States locations
- U.S. sites
- 43
- U.S. states
- 22
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | — |
| Oncology Physician's Network Inc./OPN Healthcare | Arcadia | California | 91007 | — |
| City of Hope | Duarte | California | 91010 | — |
| UCSD -Moores Cancer Center | La Jolla | California | 92093 | — |
| Pacific Shores Medical Group | Long Beach | California | 90813 | — |
| Los Angeles Hematology Oncology Medical Group | Los Angeles | California | 90017 | — |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| UC Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| UCSF Helen Diller Comprehensive Cancer Center at Mt Zion | San Francisco | California | 94115 | — |
| UCLA Hematology/Oncology | Santa Monica | California | 90404 | — |
| The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| Kaiser Permanente Medical Center | Vallejo | California | 94589 | — |
| Rocky Mountain Cancer Center | Boulder | Colorado | 80303 | — |
| Yale University, Yale Cancer Center Smilow Cancer Hospital at Yale | New Haven | Connecticut | 06510 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| Florida Hospital | Orlando | Florida | 32804 | — |
| H. Lee Moffitt Cancer Center & Research Institute | Tampa | Florida | 33612 | — |
| The Bond & Steele Clinic, P.A. dba Bond Clinic, P.A. | Winter Haven | Florida | 33881 | — |
| University Cancer & Blood Center, LLC | Athens | Georgia | 30607 | — |
| CTCA - Southeastern Regional Medical Center | Newnan | Georgia | 30265 | — |
| CTCA - Midwestern Regional Medical Center | Zion | Illinois | 60099 | — |
| Johns Hopkins Sidney Kimmel Comprehensive Cancer Center | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Minnesota Oncology Hematology, P.A. | Minneapolis | Minnesota | 55404 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Hattiesburg Clinic Hematology/Oncology | Hattiesburg | Mississippi | 39401 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| NYU Langone Medical Center | New York | New York | 10016 | — |
| Weill Cornell Medical College | New York | New York | 10065 | — |
| North Shore Hematology Oncology Associates P.C. DBA NY Cancer and Blood Specialists | Port Jefferson Station | New York | 11776 | — |
| Montefiore Einstein Medical Center for Cancer Care | The Bronx | New York | 10461 | — |
| North Shore Hematology Oncology Associates DBA New York Cancer and Blood Specialists | The Bronx | New York | 10469 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| The Ohio State University | Columbus | Ohio | 43210 | — |
| Oklahoma Cancer Specialists and Research Institute, LLC | Tulsa | Oklahoma | 74146 | — |
| CTCA - Eastern Regional Medical Center | Philadelphia | Pennsylvania | 19124 | — |
| Baptist Cancer Center | Memphis | Tennessee | 38120 | — |
| Texas Oncology- Austin | Austin | Texas | 78745 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 20 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03318939, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 12, 2026 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03318939 live on ClinicalTrials.gov.