ClinicalTrials.gov record
A Study of the Efficacy and Safety of Upadacitinib in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies
ClinicalTrials.gov ID: NCT03345849
Public ClinicalTrials.gov record NCT03345849. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo as induction therapy in adults with moderately and severely active Crohn's disease (CD).
Study identification
- NCT ID
- NCT03345849
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 526 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 7, 2017 (Actual)
- Primary completion
- Oct 15, 2021 (Actual)
- Completion
- Jan 13, 2022 (Actual)
- Last update posted
- Nov 23, 2022
2017 – 2022
United States locations
- U.S. sites
- 119
- U.S. states
- 34
- U.S. cities
- 96
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| East View Medical Research, LLC /ID# 171176 | Mobile | Alabama | 36606 | — |
| CB Flock Research Corporation /ID# 166185 | Mobile | Alabama | 36608 | — |
| Delsol Research Management, Ll /Id# 170145 | Chandler | Arizona | 85224 | — |
| HonorHealth Research Institute - Shea /ID# 164821 | Scottsdale | Arizona | 85258 | — |
| Arizona Arthritis & Rheumatology Research, PLLC /ID# 164803 | Sun City | Arizona | 85306 | — |
| Southern California Res. Ctr. /ID# 169655 | Coronado | California | 92118-1408 | — |
| Citrus Valley Gastroenterology /ID# 166173 | Covina | California | 91722-3797 | — |
| Hoag Memorial Hosp Presbyterian /ID# 222540 | Irvine | California | 92618 | — |
| United Medical Doctors /ID# 207449 | Los Alamitos | California | 90720-3309 | — |
| Gastrointestinal Biosciences Clinical Trials, LLC /ID# 164762 | Los Angeles | California | 90067-2001 | — |
| Facey Medical Foundation /ID# 203136 | Mission Hills | California | 91345 | — |
| United Medical Doctors - Murrieta /ID# 164945 | Murrieta | California | 92563 | — |
| Ucsd /Id# 164910 | San Diego | California | 92103 | — |
| Medical Assoc Research Grp /ID# 169706 | San Diego | California | 92123 | — |
| Univ of California San Francis /ID# 164944 | San Francisco | California | 94158 | — |
| Care Access Research /ID# 167767 | San Pablo | California | 94806 | — |
| Peak Gastroenterology Associates, PC /ID# 170143 | Colorado Springs | Colorado | 80907 | — |
| Delta Waves, Inc. /ID# 164776 | Colorado Springs | Colorado | 80918 | — |
| Western States Clinical Res /ID# 164760 | Wheat Ridge | Colorado | 80033-2896 | — |
| Medical Research Center of CT /ID# 164926 | Hamden | Connecticut | 06518 | — |
| Clinical Research of West Florida, Inc /ID# 205827 | Clearwater | Florida | 33765 | — |
| Clinical Research of West Florida, Inc /ID# 208118 | Clearwater | Florida | 33765 | — |
| Advanced Research - Coral Springs /ID# 218021 | Coral Springs | Florida | 33067-3173 | — |
| Encore Borland-Groover Clinical Research /Id# 203499 | Jacksonville | Florida | 32256 | — |
| Ctr for Advanced Gastroenterol /ID# 165353 | Maitland | Florida | 32751-6108 | — |
| Crystal Pharmacology Research /ID# 166081 | Miami | Florida | 33165 | — |
| Coral Research Clinic /ID# 164890 | Miami | Florida | 33186-4643 | — |
| Advanced Research Institute, Inc /ID# 164921 | New Port Richey | Florida | 34653 | — |
| Endoscopic Research, Inc. /ID# 206136 | Orlando | Florida | 32803 | — |
| Omega Research Maitland, LLC /ID# 203481 | Orlando | Florida | 32808 | — |
| Clinical Research Trials of Florida, Inc. /ID# 203485 | Tampa | Florida | 33607 | — |
| AdventHealth Tampa /ID# 171167 | Tampa | Florida | 33613-4680 | — |
| Gastroenterology Associates of Central Georgia, LLC /ID# 165478 | Macon | Georgia | 31201 | — |
| Gastroenterology Consultants PC - Roswell /ID# 218220 | Roswell | Georgia | 30076-4913 | — |
| Atlanta Gastroenterology Spec /ID# 164799 | Suwanee | Georgia | 30024 | — |
| Treasure Valley Medical Research /ID# 215032 | Boise | Idaho | 83706 | — |
| Rush University Medical Center /ID# 165497 | Chicago | Illinois | 60612 | — |
| University of Chicago Medicine /ID# 165503 | Chicago | Illinois | 60637-1426 | — |
| DuPage Medical Group /ID# 205328 | Downers Grove | Illinois | 60515-5509 | — |
| MediSphere Medical Research Center /ID# 166175 | Evansville | Indiana | 47714-8011 | — |
| Indianapolis Gastroenterology /ID# 164938 | Indianapolis | Indiana | 46237 | — |
| University of Iowa Hospitals and Clinics /ID# 165436 | Iowa City | Iowa | 52242 | — |
| Tri-State Gastroenterology /ID# 165496 | Crestview Hills | Kentucky | 41017 | — |
| University of Louisville /ID# 165366 | Louisville | Kentucky | 40202 | — |
| University of Louisville /ID# 168572 | Louisville | Kentucky | 40202 | — |
| CroNOLA, LLC /ID# 164823 | Houma | Louisiana | 70360 | — |
| Nola Research Works, LLC /ID# 164759 | New Orleans | Louisiana | 70115 | — |
| Louisana Research Center, LLC /ID# 164894 | Shreveport | Louisiana | 71105-6800 | — |
| Johns Hopkins University School of Medicine /ID# 211941 | Baltimore | Maryland | 21287-0010 | — |
| MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 164935 | Chevy Chase | Maryland | 20815 | — |
| Gastro Center of Maryland /ID# 171161 | Columbia | Maryland | 21045 | — |
| Lahey Hospital and Medical Center /ID# 214726 | Burlington | Massachusetts | 01805 | — |
| University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 164943 | Ann Arbor | Michigan | 48109 | — |
| Digestive Health Associates (DHA) - Farmington Hills /ID# 205793 | Farmington Hills | Michigan | 48334-3230 | — |
| Center for Digestive Health /ID# 164822 | Troy | Michigan | 48098-6363 | — |
| Clin Res Inst of Michigan, LLC /ID# 170133 | Troy | Michigan | 48098 | — |
| Mayo Clinic - Rochester /ID# 164783 | Rochester | Minnesota | 55905-0001 | — |
| Southern Therapy and Advanced Research (STAR) LLC /ID# 165343 | Jackson | Mississippi | 39216 | — |
| Quality Clinical Research Inc. /ID# 170137 | Omaha | Nebraska | 68114-3723 | — |
| Duplicate_CHI Nebraska d/b/a CHI Health /ID# 168578 | Omaha | Nebraska | 68124 | — |
| Las Vegas Medical Research /ID# 168588 | Las Vegas | Nevada | 89113 | — |
| AGA Clinical Research Associates, LLC /ID# 164769 | Egg Harbor | New Jersey | 08234 | — |
| Rutgers Robert Wood Johnson /ID# 166073 | New Brunswick | New Jersey | 08901 | — |
| NY Scientific /ID# 164931 | Brooklyn | New York | 11235 | — |
| United Health Services Hospitals, Inc /ID# 217485 | Johnson City | New York | 13790-2107 | — |
| NYU Langone Long Island Clinical Research Associates /ID# 164927 | Lake Success | New York | 11042 | — |
| The Mount Sinai Hospital /ID# 170257 | New York | New York | 10029 | — |
| Columbia Univ Medical Center /ID# 164782 | New York | New York | 10032-3725 | — |
| Gastoenterology Group of Rochester /ID# 166177 | Rochester | New York | 14618-5703 | — |
| Richmond University Medical Center /ID# 201857 | Staten Island | New York | 10310-1664 | — |
| Montefiore Medical Center - Moses Campus /ID# 166193 | The Bronx | New York | 10467 | — |
| Advantage Clinical Trials /ID# 168546 | The Bronx | New York | 10468 | — |
| Atrium Health Carolinas Medical Center /ID# 164932 | Charlotte | North Carolina | 28203 | — |
| PMG Research of Charlotte /ID# 171160 | Charlotte | North Carolina | 28209 | — |
| Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 164904 | Raleigh | North Carolina | 27612 | — |
| Wake Forest Baptist Medical Center /ID# 164908 | Winston-Salem | North Carolina | 27157-0001 | — |
| Plains Clinical Research Center, LLC /ID# 170140 | Fargo | North Dakota | 58104-5925 | — |
| Gastro Health Research /ID# 164791 | Cincinnati | Ohio | 45219 | — |
| University of Cincinnati /ID# 164825 | Cincinnati | Ohio | 45267-0585 | — |
| Cleveland Clinic Main Campus /ID# 209231 | Cleveland | Ohio | 44195 | — |
| The Ohio State University /ID# 170141 | Columbus | Ohio | 43210 | — |
| Optimed Research, Ltd. /ID# 205624 | Columbus | Ohio | 43235 | — |
| Hometown Urgent Care and Resea /ID# 201291 | Dayton | Ohio | 45424 | — |
| Dayton Gastroenterology, Inc. /ID# 167627 | Englewood | Ohio | 45415 | — |
| Great Lakes Medical Research, LLC /ID# 202010 | Mentor | Ohio | 44060-6211 | — |
| Digestive Disease Specialists /ID# 201064 | Oklahoma City | Oklahoma | 73112 | — |
| Options Health Research, LLC /ID# 164820 | Tulsa | Oklahoma | 74104 | — |
| Healthcare Research Consultant /ID# 166195 | Tulsa | Oklahoma | 74135 | — |
| University of Pennsylvania /ID# 168430 | Philadelphia | Pennsylvania | 19104-5502 | — |
| Pharmacorp Clinical Trials /ID# 164916 | Charleston | South Carolina | 29412 | — |
| Gastroenterology Associates, P.A. of Greenville /ID# 164771 | Greenville | South Carolina | 29615-3593 | — |
| Rapid City Medical Center - GI Research /ID# 201735 | Rapid City | South Dakota | 57701 | — |
| Gastro One /ID# 164826 | Germantown | Tennessee | 38138 | — |
| East Tennessee Research Institute /ID# 203613 | Johnson City | Tennessee | 37604 | — |
| Quality Medical Research /ID# 205263 | Nashville | Tennessee | 37211 | — |
| Vanderbilt University Medical Center /ID# 164946 | Nashville | Tennessee | 37232-0011 | — |
| TX Clinical Research Institute /ID# 164896 | Arlington | Texas | 76012 | — |
| Inquest Clinical Research /ID# 164785 | Baytown | Texas | 77521-2415 | — |
| Texas Digestive Disease Consultants /ID# 209953 | Cedar Park | Texas | 78613-5028 | — |
| Texas Digestive Disease Consultants /ID# 209801 | Cedar Park | Texas | 78613 | — |
| Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 170144 | Dallas | Texas | 75246 | — |
| CliniCore International, LLC /ID# 164902 | Houston | Texas | 77027-6812 | — |
| Baylor College of Medicine - Baylor Medical Center /ID# 164947 | Houston | Texas | 77030-3411 | — |
| Centex Studies, Inc. - Houston /ID# 201214 | Houston | Texas | 77058 | — |
| GI Specialists of Houston /ID# 202339 | Houston | Texas | 77070-4347 | — |
| Caprock Gastro Research, LLC /ID# 215438 | Lubbock | Texas | 79424-3017 | — |
| Clinical Associates in Research Therapeutics of America, LLC /ID# 164786 | San Antonio | Texas | 78212 | — |
| Southern Star Research Institute, LLC /ID# 169755 | San Antonio | Texas | 78229-5390 | — |
| Carl R. Meisner Medical Clinic /ID# 201061 | Sugar Land | Texas | 77478 | — |
| Tyler Research Institute, LLC /ID# 168687 | Tyler | Texas | 75701-4464 | — |
| Gastro Health & Nutrition - Victoria /ID# 167812 | Victoria | Texas | 77904 | — |
| HP Clinical Research /ID# 164933 | Bountiful | Utah | 84010 | — |
| Advanced Research Institute /ID# 164784 | Ogden | Utah | 84403 | — |
| Duplicate_Care Access Research /ID# 164794 | Salt Lake City | Utah | 84124-1377 | — |
| Velocity Clinical Research - Salt Lake City /ID# 166076 | West Jordan | Utah | 84088 | — |
| Washington Gastroenterology /ID# 164824 | Bellevue | Washington | 98004 | — |
| Virginia Mason Medical Center /ID# 164913 | Seattle | Washington | 98101 | — |
| The Vancouver Clinic, INC. PS /ID# 164918 | Vancouver | Washington | 98664 | — |
| Allegiance Research Specialists /ID# 165346 | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 313 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03345849, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 23, 2022 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03345849 live on ClinicalTrials.gov.