Phase 2 Study of BIIB092 in Participants With Early Alzheimer's Disease
Public ClinicalTrials.gov record NCT03352557. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Safety, Tolerability, and Efficacy of BIIB092 in Subjects With Mild Cognitive Impairment Due to Alzheimer's Disease or With Mild Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the placebo-controlled period is to evaluate the safety and tolerability of BIIB092 in participants with mild cognitive impairment (MCI) due to Alzheimer's disease (AD) or with mild AD. The secondary objectives of the placebo-controlled period are to evaluate the efficacy of multiple doses of BIIB092 in slowing cognitive and functional impairment in participants with MCI due to AD or with mild AD, and to evaluate the immunogenicity of BIIB092 after multiple doses in participants with MCI due to AD or with mild AD. The primary objective of the long-term extension period is to evaluate the long-term safety and tolerability of BIIB092 in participants with MCI due to AD or with mild AD.
Study identification
- NCT ID
- NCT03352557
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 654 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 3, 2018 (Actual)
- Primary completion
- Aug 30, 2021 (Actual)
- Completion
- Aug 30, 2021 (Actual)
- Last update posted
- Nov 8, 2022
2018 – 2021
United States locations
- U.S. sites
- 52
- U.S. states
- 16
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35205 | — |
| Xenoscience Inc | Phoenix | Arizona | 85004 | — |
| Banner Alzheimer's Institute | Phoenix | Arizona | 85006 | — |
| Dignity Health | Phoenix | Arizona | 85013 | — |
| Banner Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| Advanced Research Center, Inc. | Anaheim | California | 92805 | — |
| The Research Center of Southern California | Carlsbad | California | 92011 | — |
| Positron Research International | Fremont | California | 94538 | — |
| Neuropain Medical Center | Fresno | California | 93710 | — |
| V Royter, MD, APMC | Hanford | California | 93230 | — |
| Irvine Center for Clinical Research, Inc. | Irvine | California | 92614 | — |
| Research Center for Clinical Studies West | Lancaster | California | 93534 | — |
| Mary S. Easton Center for Alzheimer's Disease Research, UCLA | Los Angeles | California | 90095 | — |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| Stanford Hospital and Clinics | Palo Alto | California | 94304 | — |
| Pacific Research Network, Inc | San Diego | California | 92103 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| Invicro | New Haven | Connecticut | 06510 | — |
| Yale University School Of Medicine | New Haven | Connecticut | 06520 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Renstar Medical Research | Ocala | Florida | 34471 | — |
| Synexus Clinical Research US, Inc. - Orlando | Orlando | Florida | 32806 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Brain Matters Research | Stuart | Florida | 34997 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| Olympian Clinical Research | Tampa | Florida | 33614 | — |
| Synexus Clinical Research US, Inc. - The Villages | The Villages | Florida | 32162 | — |
| Emory University Cognitive Neurology Clinic & ADRC | Atlanta | Georgia | 30329 | — |
| McLean Hospital | Belmont | Massachusetts | 02478 | — |
| Tufts | Boston | Massachusetts | 02111 | — |
| Brigham and Women's Hospital Department of Neurology | Boston | Massachusetts | 02115 5804 | — |
| ActivMed Practices & Research | Methuen | Massachusetts | 01844 | — |
| Boston Center for Memory | Newton | Massachusetts | 02459 | — |
| Donald S. Marks, M.D., P.C. | Plymouth | Massachusetts | 02360 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health | Las Vegas | Nevada | 89106 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89113 | — |
| The Cognitive Research Center of New Jersey | Springfield | New Jersey | 07081 | — |
| Advanced Memory Enhancement Center of NJ | Toms River | New Jersey | 08755 | — |
| New York University Medical Center PRIME | New York | New York | 10016 | — |
| AD-CARE, University of Rochester | Rochester | New York | 14620 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10312 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Rhode Island Mood & Memory Research Institute | East Providence | Rhode Island | 02915 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Butler Hospital | Providence | Rhode Island | 02906 | — |
| Neurology Clinic, PC | Cordova | Tennessee | 38018 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| The Methodist Hospital | Houston | Texas | 77030 | — |
| The Memory Clinic, Inc. | Bennington | Vermont | 05201 | — |
| Cognition Health | Fairfax | Virginia | 22031 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 49 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03352557, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 8, 2022 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03352557 live on ClinicalTrials.gov.