Treatment of Refractory Nausea and Vomiting in Patients With Breast Cancer
Public ClinicalTrials.gov record NCT03367572. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Netupitant/Palonosetron Hydrochloride and Dexamethasone With or Without Prochlorperazine or Olanzapine in Improving Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase III trial studies how well netupitant/palonosetron hydrochloride and dexamethasone with prochlorperazine or olanzapine work compared to netupitant/palonosetron hydrochloride and dexamethasone in improving chemotherapy-induced nausea and vomiting in patients with breast cancer. Antiemetic drugs, such as prochlorperazine and olanzapine, may help lessen nausea and vomiting in patients with breast cancer treated with chemotherapy.
Study identification
- NCT ID
- NCT03367572
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,363 participants
Conditions and interventions
Conditions
Interventions
- Dexamethasone Drug
- Laboratory Biomarker Analysis Other
- Netupitant/Palonosetron Hydrochloride Drug
- Olanzapine Drug
- Placebo Other
- Prochlorperazine Drug
- Quality-of-Life Assessment Other
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 19, 2018 (Actual)
- Primary completion
- Apr 13, 2024 (Actual)
- Completion
- Apr 13, 2024 (Actual)
- Last update posted
- Sep 25, 2025
2018 – 2024
United States locations
- U.S. sites
- 18
- U.S. states
- 13
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Hawaii MU NCORP | Honolulu | Hawaii | 96813 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Gulf South MU-NCORP | New Orleans | Louisiana | 70112 | — |
| Michigan Cancer Research Consortium | Ann Arbor | Michigan | 48106 | — |
| Cancer Research Consortium of West Michigan | Grand Rapids | Michigan | 49503 | — |
| Health Partners Inc | Minneapolis | Minnesota | 55454 | — |
| Cancer Research for the Ozarks NCORP | Springfield | Missouri | 65804 | — |
| Nevada Cancer Research Foundation NCORP | Las Vegas | Nevada | 89106 | — |
| University of Rochester NCORP Research Base | Rochester | New York | 14642 | — |
| Southeast Clinical Oncology Research Program | Winston-Salem | North Carolina | 27104 | — |
| Columbus NCORP | Columbus | Ohio | 43215 | — |
| Dayton Clinical Oncology Program | Dayton | Ohio | 45459 | — |
| Geisinger Cancer Institute NCORP | Danville | Pennsylvania | 17822 | — |
| Greenville NCORP | Greenville | South Carolina | 29615 | — |
| Upstate Carolina NCORP | Spartanburg | South Carolina | 29303 | — |
| Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | 54301 | — |
| Gundersen Health System | La Crosse | Wisconsin | 54601 | — |
| Aurora NCORP | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03367572, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 25, 2025 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03367572 live on ClinicalTrials.gov.