Minocycline Pharmacokinetics (ACUMIN)
Public ClinicalTrials.gov record NCT03369951. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase IV Open-Label Pharmacokinetic Study of Minocycline for Injection Following a Single Infusion in Critically-Ill Adults (ACUMIN)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase IV, multi-center open-label pharmacokinetic trial studying the pharmacokinetics and pharmacodynamics of a single dose of Minocin IV. Up to 67 subjects will be enrolled to obtain 50 evaluable, ICU patients who are already receiving antimicrobial therapy for a known or suspected Gram-negative infection. The entire study duration will be approximately 16 months and each subject participation duration will be approximately 2 days. The study will be conducted at approximately 13 clinical sites. Each subject will receive a single 200 mg dose of Minocin IV infused over approximately 60 minutes. Each subject will have 7 PK samples collected (1 pre-dose, 6 post-dose) at designated time points over a \~48 hour period following the start of the Minocin IV infusion. The primary objectives are: 1) To characterize minocycline PK at the population level in critically-ill adults, with illness known or suspected to be caused by infection with Gram-negative bacteria and 2) To assess patient-level and clinical covariates associated with minocycline pharmacokinetic properties in critically-ill adults, with illness known or suspected to be caused by infection with Gram-negative bacteria.
Study identification
- NCT ID
- NCT03369951
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 58 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 27, 2018
- Primary completion
- Jul 19, 2019
- Completion
- Jul 19, 2019
- Last update posted
- Dec 2, 2020
2018 – 2019
United States locations
- U.S. sites
- 15
- U.S. states
- 9
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Emory Decatur Hospital - Clinical Trials - Immunology/Infectious Disease | Decatur | Georgia | 30033 | — |
| Northwestern Memorial Hospital - ICU | Chicago | Illinois | 60611-2908 | — |
| Northwestern Medicine - Department of Obstetrics and Gynecology - Division of Female Pelvic Medicine and Reconstructive Surgery | Chicago | Illinois | 60611 | — |
| University of Kentucky - UK Albert B Chandler Hospital | Lexington | Kentucky | 40536 | — |
| University of Louisville School of Medicine - Surgery | Louisville | Kentucky | 40202-1622 | — |
| Henry Ford Health System - Henry Ford Hospital | Detroit | Michigan | 48202-2608 | — |
| William Beaumont Hospital - Royal Oak Campus - Infectious Disease | Royal Oak | Michigan | 48073-6700 | — |
| Washington University School of Medicine in St. Louis - Infectious Diseases | St Louis | Missouri | 63110-1010 | — |
| Duke University School of Medicine - Duke Clinical Research Institute - Duke Clinical Research Unit | Durham | North Carolina | 27701 | — |
| Duke University Hospital - Duke Medicine Pavilion - MICU | Durham | North Carolina | 27710 | — |
| East Carolina University - Infectious Diseases and Tropical/Travel Medicine Clinic | Greenville | North Carolina | 27834-9997 | — |
| University of Cincinnati College of Medicine - Division of Infectious Diseases | Cincinnati | Ohio | 45267 | — |
| Case Western Reserve University School of Medicine - Medicine - Infectious Diseases and HIV Medicine | Cleveland | Ohio | 44106-1716 | — |
| Oregon Health and Science University - Division of Pulmonary and Critical Care Medicine | Portland | Oregon | 97239 | — |
| University of Pittsburgh - Medicine - Infectious Diseases | Pittsburgh | Pennsylvania | 15213-3403 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03369951, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 2, 2020 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03369951 live on ClinicalTrials.gov.