Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE)
Public ClinicalTrials.gov record NCT03373045. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
The CHRONICLE Study: A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals With Severe Asthma in the United States
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The CHRONICLE Study is a multi-center, non-interventional, prospective cohort study of adults with severe asthma who do not achieve control with high-dose inhaled corticosteroid (ICS) therapy with additional controllers and/or require systemic corticosteroid or monoclonal antibody therapy. Data will be collected from the healthcare provider in a uniform manner for every patient enrolled using an electronic case report form (eCRF). Data will be collected monthly from patients via web-based surveys. Patients will be followed until study discontinuation or the patient withdraws from the study or death, whichever occurs first. The expectation is that patients will be followed for a period of at least 3 years.
Study identification
- NCT ID
- NCT03373045
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 18 participants
Conditions and interventions
Conditions
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 18 Years to 130 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 27, 2018 (Actual)
- Primary completion
- Feb 14, 2025 (Actual)
- Completion
- Feb 14, 2025 (Actual)
- Last update posted
- Sep 24, 2025
2018 – 2025
United States locations
- U.S. sites
- 174
- U.S. states
- 42
- U.S. cities
- 149
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35209 | — |
| Research Site | Birmingham | Alabama | 35294 | — |
| Research Site | Hoover | Alabama | 35244 | — |
| Research Site | Gilbert | Arizona | 85234 | — |
| Research Site | Peoria | Arizona | 85381 | — |
| Research Site | Little Rock | Arkansas | 72205 | — |
| Research Site | Bakersfield | California | 93301 | — |
| Research Site | Loma Linda | California | 92354 | — |
| Research Site | Los Angeles | California | 90025 | — |
| Research Site | Mission Viejo | California | 92691 | — |
| Research Site | Modesto | California | 95355-4201 | — |
| Research Site | Redondo Beach | California | 90277 | — |
| Research Site | Riverside | California | 92506 | — |
| Research Site | Roseville | California | 95661 | — |
| Research Site | Sacramento | California | 95819 | — |
| Research Site | San Diego | California | 92103 | — |
| Research Site | San Diego | California | 92123 | — |
| Research Site | San Diego | California | 92130-3318 | — |
| Research Site | Santa Monica | California | 90404 | — |
| Research Site | Studio City | California | 91607 | — |
| Research Site | Ventura | California | 93003 | — |
| Research Site | Westminster | California | 92683 | — |
| Research Site | Aurora | Colorado | 80045 | — |
| Research Site | Danbury | Connecticut | 06810 | — |
| Research Site | Farmington | Connecticut | 06030 | — |
| Research Site | New Haven | Connecticut | 06510 | — |
| Research Site | Waterbury | Connecticut | 06708 | — |
| Research Site | Newark | Delaware | 19713 | — |
| Research Site | Brandon | Florida | 33511 | — |
| Research Site | Clearwater | Florida | 33765 | — |
| Research Site | Coral Gables | Florida | 33134 | — |
| Research Site | Gainesville | Florida | 32608 | — |
| Research Site | Jacksonville | Florida | 32204 | — |
| Research Site | Kissimmee | Florida | 34759 | — |
| Research Site | Lake Mary | Florida | 32746 | — |
| Research Site | Miami | Florida | 33032 | — |
| Research Site | Miami | Florida | 33175 | — |
| Research Site | Miami | Florida | 33176 | — |
| Research Site | Miami Beach | Florida | 33140 | — |
| Research Site | Pensacola | Florida | 32504 | — |
| Research Site | Plantation | Florida | 33317 | — |
| Research Site | St. Petersburg | Florida | 33704 | — |
| Research Site | Tallahassee | Florida | 32308 | — |
| Research Site | Tampa | Florida | 32789 | — |
| Research Site | Tampa | Florida | 33613 | — |
| Research Site | Albany | Georgia | 31707 | — |
| Research Site | Decatur | Georgia | 30033 | — |
| Research Site | Gainesville | Georgia | 30501 | — |
| Research Site | Villa Rica | Georgia | 30180 | — |
| Research Site | Boise | Idaho | 83706 | — |
| Research Site | Chicago | Illinois | 60611 | — |
| Research Site | Chicago | Illinois | 60612 | — |
| Research Site | Glen Ellyn | Illinois | 60137 | — |
| Research Site | Fort Wayne | Indiana | 46804 | — |
| Research Site | Iowa City | Iowa | 52242 | — |
| Research Site | West Des Moines | Iowa | 50266 | — |
| Research Site | Overland Park | Kansas | 66210 | — |
| Research Site | Georgetown | Kentucky | 40324 | — |
| Research Site | Lexington | Kentucky | 40503 | — |
| Research Site | Lexington | Kentucky | 40509 | — |
| Research Site | Louisville | Kentucky | 40215 | — |
| Research Site | New Orleans | Louisiana | 70112 | — |
| Research Site | New Orleans | Louisiana | 70127 | — |
| Research Site | Shreveport | Louisiana | 71106 | — |
| Research Site | Bangor | Maine | 04401 | — |
| Research Site | Rockville | Maryland | 20850 | — |
| Research Site | Rockville | Maryland | 20852 | — |
| Research Site | Silver Spring | Maryland | 20902 | — |
| Research Site | Burlington | Massachusetts | 01805 | — |
| Research Site | North Dartmouth | Massachusetts | 02747 | — |
| Research Site | Ann Arbor | Michigan | 48106 | — |
| Research Site | Ann Arbor | Michigan | 48109 | — |
| Research Site | Clinton Township | Michigan | 48038 | — |
| Research Site | Detroit | Michigan | 48202 | — |
| Research Site | Hamtramck | Michigan | 48211 | — |
| Research Site | Wyoming | Michigan | 49519 | — |
| Research Site | Maplewood | Minnesota | 55109 | — |
| Research Site | Minneapolis | Minnesota | 55455 | — |
| Research Site | Plymouth | Minnesota | 55402 | — |
| Research Site | Rochester | Minnesota | 55905 | — |
| Research Site | St Louis | Missouri | 63110 | — |
| Research Site | Lincoln | Nebraska | 68505 | — |
| Research Site | Omaha | Nebraska | 68105 | — |
| Research Site | Omaha | Nebraska | 68114 | — |
| Research Site | Omaha | Nebraska | 68124 | — |
| Research Site | Las Vegas | Nevada | 89106 | — |
| Research Site | Brick | New Jersey | 08724 | — |
| Research Site | Marlton | New Jersey | 08053 | — |
| Research Site | New Brunswick | New Jersey | 08901 | — |
| Research Site | North Bergen | New Jersey | 07047 | — |
| Research Site | Northfield | New Jersey | 08225 | — |
| Research Site | Toms River | New Jersey | 08755 | — |
| Research Site | Verona | New Jersey | 07044 | — |
| Research Site | Albuquerque | New Mexico | 87109 | — |
| Research Site | Bayside | New York | 11361 | — |
| Research Site | Brooklyn | New York | 11230 | — |
| Research Site | Brooklyn | New York | 11236 | — |
| Research Site | Corning | New York | 14830 | — |
| Research Site | Great Neck | New York | 11023 | — |
| Research Site | Jamaica | New York | 11418 | — |
| Research Site | Mineola | New York | 11501 | — |
| Research Site | New Hyde Park | New York | 11042 | — |
| Research Site | New Paltz | New York | 12561 | — |
| Research Site | New York | New York | 10022 | — |
| Research Site | Rochester | New York | 14621 | — |
| Research Site | Rochester | New York | 14642 | — |
| Research Site | Rockville Centre | New York | 11570 | — |
| Research Site | Staten Island | New York | 10305 | — |
| Research Site | The Bronx | New York | 10458 | — |
| Research Site | The Bronx | New York | 10459 | — |
| Research Site | The Bronx | New York | 10461 | — |
| Research Site | The Bronx | New York | 10465 | — |
| Research Site | Valhalla | New York | 10595 | — |
| Research Site | Asheville | North Carolina | 28801 | — |
| Research Site | Chapel Hill | North Carolina | 27599 | — |
| Research Site | Charlotte | North Carolina | 28204 | — |
| Research Site | Charlotte | North Carolina | 28277 | — |
| Research Site | Durham | North Carolina | 27701 | — |
| Research Site | Fayetteville | North Carolina | 28304 | — |
| Research Site | Greenville | North Carolina | 27834 | — |
| Research Site | Winston-Salem | North Carolina | 27157 | — |
| Research Site | Fargo | North Dakota | 58104 | — |
| Research Site | Toledo | Ohio | 43617 | — |
| Research Site | Oklahoma City | Oklahoma | 73120 | — |
| Research Site | Oklahoma City | Oklahoma | 73131 | — |
| Research Site | Corvallis | Oregon | 97330 | — |
| Research Site | Portland | Oregon | 97220 | — |
| Research Site | Portland | Oregon | 97225 | — |
| Research Site | Altoona | Pennsylvania | 16601 | — |
| Research Site | Blue Bell | Pennsylvania | 19422 | — |
| Research Site | DuBois | Pennsylvania | 15801 | — |
| Research Site | Harrisburg | Pennsylvania | 17109 | — |
| Research Site | Philadelphia | Pennsylvania | 19107 | — |
| Research Site | Pittsburgh | Pennsylvania | 15241 | — |
| Research Site | Sayre | Pennsylvania | 18840 | — |
| Research Site | Yardley | Pennsylvania | 19067 | — |
| Research Site | Lincoln | Rhode Island | 02865 | — |
| Research Site | Clinton | South Carolina | 29325 | — |
| Research Site | Greenville | South Carolina | 29607 | — |
| Research Site | Mt. Pleasant | South Carolina | 29464 | — |
| Research Site | North Charleston | South Carolina | 29420 | — |
| Research Site | Rock Hill | South Carolina | 29732 | — |
| Research Site | Franklin | Tennessee | 37064 | — |
| Research Site | Hendersonville | Tennessee | 37075 | — |
| Research Site | Aransas Pass | Texas | 78336 | — |
| Research Site | Beaumont | Texas | 77702 | — |
| Research Site | Dallas | Texas | 75246 | — |
| Research Site | Denison | Texas | 75020 | — |
| Research Site | Duncanville | Texas | 75116 | — |
| Research Site | Fort Worth | Texas | 76107 | — |
| Research Site | Houston | Texas | 77030 | — |
| Research Site | Houston | Texas | 77043 | — |
| Research Site | Houston | Texas | 77079 | — |
| Research Site | Katy | Texas | 77450 | — |
| Research Site | Kingwood | Texas | 77339 | — |
| Research Site | Live Oak | Texas | 78233 | — |
| Research Site | McKinney | Texas | 75069 | — |
| Research Site | San Antonio | Texas | 78251 | — |
| Research Site | Sugar Land | Texas | 77478 | — |
| Research Site | Murray | Utah | 84107 | — |
| Research Site | Salt Lake City | Utah | 84132 | — |
| Research Site | Lynchburg | Virginia | 24501 | — |
| Research Site | Newport News | Virginia | 23606 | — |
| Research Site | Norfolk | Virginia | 23507 | — |
| Research Site | Richmond | Virginia | 23229 | — |
| Research Site | Richmond | Virginia | 23235 | — |
| Research Site | Richmond | Virginia | 23298 | — |
| Research Site | Tacoma | Washington | 98405 | — |
| Research Site | Vancouver | Washington | 98664 | — |
| Research Site | Charleston | West Virginia | 25304 | — |
| Research Site | Greenfield | Wisconsin | 53228 | — |
| Research Site | Madison | Wisconsin | 53792-9988 | — |
| Research Site | Onalaska | Wisconsin | 54650 | — |
| Research Site | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03373045, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 24, 2025 · Synced Nov 7, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03373045 live on ClinicalTrials.gov.