Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel (PANOVA-3)
Public ClinicalTrials.gov record NCT03377491. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Pivotal, Randomized, Open-label Study of Tumor Treating Fields (TTFields, 150kHz) Concomitant With Gemcitabine and Nab-paclitaxel for Front-line Treatment of Locally-advanced Pancreatic Adenocarcinoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Brief Summary: The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of Tumor Treating Fields (TTFields) in combination with gemcitabine and nab-paclitaxel, for front line treatment of locally-advanced pancreatic adenocarcinoma.The device is an experimental, portable, battery operated device for chronic administration of alternating electric fields (termed TTFields or TTF) to the region of the malignant tumor, by means of surface, insulated electrode arrays.
Study identification
- NCT ID
- NCT03377491
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 571 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 10, 2018 (Actual)
- Primary completion
- Oct 16, 2024 (Actual)
- Completion
- Oct 16, 2024 (Actual)
- Last update posted
- Jan 21, 2026
2018 – 2024
United States locations
- U.S. sites
- 74
- U.S. states
- 30
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Grandview Medical Center, Cancer Center | Birmingham | Alabama | 35243 | — |
| Infirmary Cancer Care | Mobile | Alabama | 36607 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Arizona Oncology Associates, PC- HOPE - US Oncology Research | Tucson | Arizona | 85711 | — |
| University of Arizona Cancer Center | Tucson | Arizona | 85724-5024 | — |
| Pacific Cancer Medical Center | Anaheim | California | 92801 | — |
| Providence Medical Foundation | Fullerton | California | 92835 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Dignity Health - Mercy Cancer Centers | Sacramento | California | 95816 | — |
| Sutter Cancer Center Sacramento | Sacramento | California | 95816 | — |
| Ridley-Tree Cancer Center | Santa Barbara | California | 93105 | — |
| Adventist Health St. Helena - Martin-O'Neil Cancer Center (MOCC) | St. Helena | California | 94574 | — |
| Associated Neurologists of Southern Connecticut, P.C. | Milford | Connecticut | 06460 | — |
| Boca Raton Regional Hospital, Lynn Cancer Institute | Boca Raton | Florida | 33486 | — |
| Cancer Specialist of North Florida | Fleming Island | Florida | 32003 | — |
| Florida Cancer Specialists & Research Institute - Colonial Office | Fort Myers | Florida | 33905 | — |
| Mayo Clinic Hospital - Florida | Jacksonville | Florida | 32224 | — |
| Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| AdventHealth Neuro Oncology | Orlando | Florida | 32804 | — |
| BRCR Medical Center INC | Plantation | Florida | 33324 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| Florida Hospital Tampa | Tampa | Florida | 33613 | — |
| Piedmont Cancer Institute | Atlanta | Georgia | 30318 | — |
| Illinois Cancer Specialist - US Oncology Research | Arlington Heights | Illinois | 60005 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| NorthShore University HealthSystem | Evanston | Illinois | 60201 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| University of Kansas Medical Cancer Center | Fairway | Kansas | 66205 | — |
| Cotton O'Neil Cancer Center (Stormont-Vail Cancer Center) | Topeka | Kansas | 66606 | — |
| Saint Elizabeth Healthcare | Edgewood | Kentucky | 41017 | — |
| Norton Cancer Institute, Norton Healthcare Pavilion | Louisville | Kentucky | 40202 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | — |
| Central Maine Medical Center, Clinical Research Department | Lewiston | Maine | 04240 | — |
| University of Maryland Comprehensive Cancer Center | Baltimore | Maryland | 21201 | — |
| Maryland Oncology Hematology, P.A - US Oncology Research | Columbia | Maryland | 21044 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| UMass Memorial Medical Center | Worcester | Massachusetts | 01605 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Cancer and Hematology Centers of Western Michigan, PC | Grand Rapids | Michigan | 49503 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| MidAmerica Division | Kansas City | Missouri | 64132 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| OptumCare Cancer Care | Las Vegas | Nevada | 89102 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89619 | — |
| Renown Regional Medical Center & Renown Institute for Cancer | Reno | Nevada | 89502 | — |
| Astera Cancer Care | East Brunswick | New Jersey | 08816 | — |
| Kaleida Health | Buffalo | New York | 14210 | — |
| Bassett Medical Center | Cooperstown | New York | 13326 | — |
| New York Hospital Queens | Flushing | New York | 11355 | — |
| NYU Langone Arena Oncology | Lake Success | New York | 11042 | — |
| White Plains Hospital - Center for Cancer Care | White Plains | New York | 10601 | — |
| Novant Health Oncology Specialists | Winston-Salem | North Carolina | 27103 | — |
| Gabrail Cancer Research Center | Canton | Ohio | 44718 | — |
| Toledo Clinic Cancer Centers | Toledo | Ohio | 44614 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Willamette Valley Cancer Institute and Research Center - US Oncology Research | Eugene | Oregon | 97401 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Vita Medical Associates, P.C. | Fountain Hill | Pennsylvania | 18015 | — |
| UT/Erlanger Oncology & Hematology | Chattanooga | Tennessee | 37403 | — |
| Tennessee Cancer Specialists | Knoxville | Tennessee | 37909-1327 | — |
| Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| Texas Oncology - Beaumont Mamie McFaddin Ward Cancer Center - US Oncology Research | Beaumont | Texas | 77702 | — |
| Texas Oncology - Bedford - US Oncology Reasearch | Bedford | Texas | 76022 | — |
| Methodist Regional Cancer Center | Dallas | Texas | 75203 | — |
| Texas Oncology - Baylor - US Oncology Research | Dallas | Texas | 75246 | — |
| Texas Oncology - El Paso Cancer Treatment Center Gateway - US Oncology Research | El Paso | Texas | 79915 | — |
| Houston Methodist Cancer Center | Houston | Texas | 77030 | — |
| Baylor Scott and White Medical Center | Temple | Texas | 76508 | — |
| Texas Oncology - Tyler - US Oncology Research | Tyler | Texas | 75702 | — |
| Oncology and Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care - US Oncology Research | Roanoke | Virginia | 24014 | — |
| Vista Oncology Inc PS | Olympia | Washington | 98506 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| West Virginia University Cancer Institute | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 125 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03377491, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 21, 2026 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03377491 live on ClinicalTrials.gov.