Study of ISIS 678354 (AKCEA-APOCIII-LRx) in Participants With Hypertriglyceridemia and Established Cardiovascular Disease (CVD)
Public ClinicalTrials.gov record NCT03385239. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-Controlled, Dose-Ranging Phase 2 Study of ISIS 678354 Administered Subcutaneously to Patients With Hypertriglyceridemia and Established Cardiovascular Disease (CVD) or at a High Risk for CVD
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This was a multicenter, randomized, double-blind, placebo-controlled, dose-ranging study to evaluate the safety, including tolerability, of ISIS 678354 and to assess the efficacy of different doses and dosing regimens of ISIS 678354 for reduction of serum triglyceride (TG) levels in participants with hypertriglyceridemia and established CVD or at a high risk for CVD.
Study identification
- NCT ID
- NCT03385239
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 114 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 30, 2018 (Actual)
- Primary completion
- Nov 25, 2019 (Actual)
- Completion
- Feb 25, 2020 (Actual)
- Last update posted
- Jan 11, 2023
2018 – 2020
United States locations
- U.S. sites
- 24
- U.S. states
- 18
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Site | Cottonwood | Arizona | 86326 | — |
| Clinical Site | Little Rock | Arkansas | 72205 | — |
| Clinical Site | Carmichael | California | 95608 | — |
| Clinical Site | Fresno | California | 93720 | — |
| Clinical Site | La Jolla | California | 92037-7410 | — |
| Clinical Site | Long Beach | California | 90807 | — |
| Clinical Site | Montclair | California | 91763 | — |
| Clinical Site | Wilmington | Delaware | 19803 | — |
| Clinical Site | Boca Raton | Florida | 33434 | — |
| Clinical Site | Jacksonville | Florida | 32216 | — |
| Clinical Site | New Port Richey | Florida | 34652 | — |
| Clinical Site | Munster | Indiana | 46321 | — |
| Clinical Site | Ames | Iowa | 50010 | — |
| Clinical Site | Kansas City | Kansas | 66160 | — |
| Clinical Site | Louisville | Kentucky | 40213 | — |
| Clinical Site | Fall River | Massachusetts | 02721 | — |
| Clinical Site | Cooperstown | New York | 13326 | — |
| Clinical Site | High Point | North Carolina | 27262 | — |
| Clinical Site | Portland | Oregon | 97239 | — |
| Clinical Site | Lansdale | Pennsylvania | 19446 | — |
| Clinical Site | Providence | Rhode Island | 02906 | — |
| Clinical Site | Greer | South Carolina | 29651 | — |
| Clinical Site | Houston | Texas | 77030 | — |
| Clinical Site | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03385239, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 11, 2023 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03385239 live on ClinicalTrials.gov.