Study of Safety and Efficacy of Brolucizumab 6 mg Drug Product Intended for Commercialization in Patients With nAMD
Public ClinicalTrials.gov record NCT03386474. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 24-week, Double-masked, Multicenter, Two-arm Extension Study to Collect Safety and Efficacy Data on Brolucizumab 6 mg Drug Product Intended for Commercialization in Patients With Neovascular Age-related Macular Degeneration Who Have Completed the CRTH258A2301 Study
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this extension study was to assess the safety and efficacy of the new formulation of brolucizumab 6 mg ophthalmic solution when given to the same patients who received brolucizumab in the core trial CRTH258A2301 (also known as CRTH258-C002). The medical condition treated in the core and extension trials was neo-vascular age-related macular degeneration (nAMD).
Study identification
- NCT ID
- NCT03386474
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 151 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 15, 2018 (Actual)
- Primary completion
- Sep 6, 2018 (Actual)
- Completion
- Sep 6, 2018 (Actual)
- Last update posted
- Jan 5, 2021
2018
United States locations
- U.S. sites
- 63
- U.S. states
- 24
- U.S. cities
- 59
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Novartis Investigative Site | Peoria | Arizona | 85381 | — |
| Novartis Investigative Site | Phoenix | Arizona | 85014 | — |
| Novartis Investigative Site | Arcadia | California | 91006 | — |
| Novartis Investigative Site | Huntington Beach | California | 92647 | — |
| Novartis Investigative Site | La Jolla | California | 92093 | — |
| Novartis Investigative Site | Loma Linda | California | 92354 | — |
| Novartis Investigative Site | Mountain View | California | 94040 | — |
| Novartis Investigative Site | Oakland | California | 94609 | — |
| Novartis Investigative Site | Redlands | California | 92374 | — |
| Novartis Investigative Site | Sacramento | California | 95841 | — |
| Novartis Investigative Site | Colorado Springs | Colorado | 80909 | — |
| Novartis Investigative Site | Golden | Colorado | 80401 | — |
| Novartis Investigative Site | Bridgeport | Connecticut | 06606 | — |
| Novartis Investigative Site | New London | Connecticut | 06320 | — |
| Novartis Investigative Site | Altamonte Springs | Florida | 32701 | — |
| Novartis Investigative Site | Deerfield Beach | Florida | 33064 | — |
| Novartis Investigative Site | Fort Myers | Florida | 33912-7125 | — |
| Novartis Investigative Site | Ocala | Florida | 34474 | — |
| Novartis Investigative Site | Palm Beach Gardens | Florida | 33410 | — |
| Novartis Investigative Site | Pensacola | Florida | 32503 | — |
| Novartis Investigative Site | Sarasota | Florida | 34239 | — |
| Novartis Investigative Site | Tallahassee | Florida | 32308 | — |
| Novartis Investigative Site | Vero Beach | Florida | 32960 | — |
| Novartis Investigative Site | Winter Haven | Florida | 33880 | — |
| Novartis Investigative Site | Boise | Idaho | 83713 | — |
| Novartis Investigative Site | Bloomington | Illinois | 61704 | — |
| Novartis Investigative Site | Indianapolis | Indiana | 46280 | — |
| Novartis Investigative Site | Leawood | Kansas | 66211 | — |
| Novartis Investigative Site | Shawnee Mission | Kansas | 66204 | — |
| Novartis Investigative Site | Portland | Maine | 04102 | — |
| Novartis Investigative Site | Baltimore | Maryland | 21237-4350 | — |
| Novartis Investigative Site | Waldorf | Maryland | 20602 | — |
| Novartis Investigative Site | Las Vegas | Nevada | 89144 | — |
| Novartis Investigative Site | Reno | Nevada | 89502 | — |
| Novartis Investigative Site | Toms River | New Jersey | 08755 | — |
| Novartis Investigative Site | Albuquerque | New Mexico | 87102 | — |
| Novartis Investigative Site | Rochester | New York | 14620 | — |
| Novartis Investigative Site | Rochester | New York | 14642 | — |
| Novartis Investigative Site | Shirley | New York | 11967 | — |
| Novartis Investigative Site | Syracuse | New York | 13224 | — |
| Novartis Investigative Site | Charlotte | North Carolina | 28210 | — |
| Novartis Investigative Site | Southern Pines | North Carolina | 28387 | — |
| Novartis Investigative Site | Cleveland | Ohio | 44122 | — |
| Novartis Investigative Site | Cleveland | Ohio | 44195 | — |
| Novartis Investigative Site | Dublin | Ohio | 43016 | — |
| Novartis Investigative Site | Fairfield | Ohio | 45014 | — |
| Novartis Investigative Site | Camp Hill | Pennsylvania | 17011 | — |
| Novartis Investigative Site | Nashville | Tennessee | 37203 | — |
| Novartis Investigative Site | Abilene | Texas | 79606 | — |
| Novartis Investigative Site | Austin | Texas | 78731 | — |
| Novartis Investigative Site | Fort Worth | Texas | 76104 | — |
| Novartis Investigative Site | Houston | Texas | 77025 | — |
| Novartis Investigative Site | Houston | Texas | 77030 | — |
| Novartis Investigative Site | Plano | Texas | 75093 | — |
| Novartis Investigative Site | San Antonio | Texas | 78215 | — |
| Novartis Investigative Site | San Antonio | Texas | 78240 | — |
| Novartis Investigative Site | Richmond | Virginia | 23235 | — |
| Novartis Investigative Site | Warrenton | Virginia | 20186 | — |
| Novartis Investigative Site | Silverdale | Washington | 98383 | — |
| Novartis Investigative Site | Spokane | Washington | 99204 | — |
| Novartis Investigative Site | University Place | Washington | 98467 | — |
| Novartis Investigative Site | Morgantown | West Virginia | 26506 | — |
| Novartis Investigative Site | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03386474, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 5, 2021 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03386474 live on ClinicalTrials.gov.