ClinicalTrials.gov record
Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC
ClinicalTrials.gov ID: NCT03395197
Public ClinicalTrials.gov record NCT03395197. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF TALAZOPARIB WITH ENZALUTAMIDE IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study compares rPFS in men with mCRPC treated with talazoparib plus enzalutamide vs. enzalutamide after confirmation of the starting dose of talazoparib in combination with enzalutamide.
Study identification
- NCT ID
- NCT03395197
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,054 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 18, 2017 (Actual)
- Primary completion
- Oct 3, 2022 (Actual)
- Completion
- Jun 30, 2027 (Estimated)
- Last update posted
- Oct 14, 2026
2017 – 2027
United States locations
- U.S. sites
- 132
- U.S. states
- 27
- U.S. cities
- 96
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alaska Urological Institute dba Alaska Clinical Research Center | Anchorage | Alaska | 99503 | — |
| Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers | Chandler | Arizona | 85224 | — |
| Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers | Gilbert | Arizona | 85297 | — |
| Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers | Mesa | Arizona | 85202 | — |
| Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers | Mesa | Arizona | 85206 | — |
| Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers | Scottsdale | Arizona | 85260 | — |
| Arizona Urology Specialists | Tucson | Arizona | 85715 | — |
| Arizona Urology Specialists | Tucson | Arizona | 85741 | — |
| Beverly Hills Cancer Center | Beverly Hills | California | 90211 | — |
| South County Hematology/Oncology | Chula Vista | California | 91911 | — |
| Sharp Rees-Stealy | Chula Vista | California | 91913 | — |
| Glendale Adventist Medical Center | Glendale | California | 91206 | — |
| Marin Cancer Care, Inc. | Greenbrae | California | 94904 | — |
| Cancer Center Oncology Medical Group | La Mesa | California | 91942 | — |
| Loma Linda University Cancer Center - Records Management Only | Loma Linda | California | 92350 | — |
| Loma Linda University Cancer Center - Hematology/Oncology Clinic | Loma Linda | California | 92354 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| VA Long Beach Healthcare System | Long Beach | California | 90822 | — |
| UCLA Clark Urology Center | Los Angeles | California | 90095 | — |
| University of California, Irvine Medical Center | Orange | California | 92868 | — |
| Stanford Cancer Institute | Palo Alto | California | 94304 | — |
| Desert Hematology Oncology Medical Group, Incorporation | Rancho Mirage | California | 92270 | — |
| Eisenhower Medical Center | Rancho Mirage | California | 92270 | — |
| Medical Oncology Associates-SD | San Diego | California | 92123 | — |
| Sharp Memorial Hospital Investigational Pharmacy | San Diego | California | 92123 | — |
| Sharp Rees-Stealy | San Diego | California | 92123 | — |
| Stanford Health Care | Stanford | California | 94305 | — |
| University of Colorado Denver CTO/CTRC | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital - Anschutz Cancer Pavilion | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital- Anschutz Inpatient Pavilion | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital- Anschutz Outpatient Pavilion | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| The Urology Center of Colorado | Denver | Colorado | 80211 | — |
| Florida Cancer Specialists | Altamonte Springs | Florida | 32701 | — |
| Florida Cancer Specialists | Brandon | Florida | 33511 | — |
| Florida Cancer Specialists | Clearwater | Florida | 33761 | — |
| Florida Cancer Specialists | Daytona Beach | Florida | 32117 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33905 | — |
| Florida Cancer Specialists | Gainesville | Florida | 32605 | — |
| Lakeland Regional Health Hollis Cancer Center | Lakeland | Florida | 33805 | — |
| Florida Cancer Specialists | Largo | Florida | 33770 | — |
| Florida Cancer Specialists | Lecanto | Florida | 34461 | — |
| Florida Cancer Specialists | New Port Richey | Florida | 34655 | — |
| Florida Cancer Specialists | Ocala | Florida | 34471 | — |
| Florida Cancer Specialists | Orange City | Florida | 32763 | — |
| AdventHealth Medical Group Hermatology and Oncology | Orlando | Florida | 32804 | — |
| Investigational Drug Services, Advent Health Orlando | Orlando | Florida | 32804 | — |
| Florida Cancer Specialists | Orlando | Florida | 32806 | — |
| Florida Cancer Specialists | Spring Hill | Florida | 34608 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists | Stuart | Florida | 34994 | — |
| Florida Cancer Specialists | Tampa | Florida | 33607 | — |
| Florida Cancer Specialists | Tavares | Florida | 32778 | — |
| Florida Cancer Specialists | The Villages | Florida | 32159 | — |
| Florida Cancer Specialists | Vero Beach | Florida | 32960 | — |
| Florida Cancer Specialists | Wellington | Florida | 33414 | — |
| Florida Cancer Specialists | West Palm Beach | Florida | 33401 | — |
| Florida Cancer Specialists | Winter Park | Florida | 32792 | — |
| Piedmont Cancer Institute | Atlanta | Georgia | 30318 | — |
| Piedmont Cancer Institute | Fayetteville | Georgia | 30214 | — |
| Piedmont Cancer Institute | Newnan | Georgia | 30265 | — |
| Southeastern Regional Medical Center | Newnan | Georgia | 30265 | — |
| Cook County Health (CCH) | Chicago | Illinois | 60612 | — |
| John H. Stroger, Jr. Hospital of Cook County/IND Pharmacy | Chicago | Illinois | 60612 | — |
| AMITA Health Adventist Medical Center Hinsdale | Hinsdale | Illinois | 60521 | — |
| AMITA Health Cancer Institute | Hinsdale | Illinois | 60521 | — |
| Midwestern Regional Medical Center | Zion | Illinois | 60099 | — |
| Clark Memorial Hospital Radiology | Jeffersonville | Indiana | 47130 | — |
| First Urology, PSC | Jeffersonville | Indiana | 47130 | — |
| University of Iowa Hospital and Clinics | Iowa City | Iowa | 52242 | — |
| The University of Kansas Clinical Research Center | Fairway | Kansas | 66205 | — |
| The University of Kansas Cancer Center | Westwood | Kansas | 66205 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| VA Saint Louis Healthcare System | St Louis | Missouri | 63106 | — |
| XCancer Omaha / Urology Cancer Center, PC d/b/a XCancer | Omaha | Nebraska | 68130 | — |
| Clara Maass Medical Center | Belleville | New Jersey | 07109 | — |
| New Jersey Cancer Care and Blood Disorders | Belleville | New Jersey | 07109 | — |
| University Radiology | Nutley | New Jersey | 07110 | — |
| New Jersey Urology, LLC | Voorhees Township | New Jersey | 08043 | — |
| Urology Group of New Mexico | Albuquerque | New Mexico | 87109 | — |
| San Juan Oncology Associates | Farmington | New Mexico | 87401 | — |
| Premier Medical Group of the Hudson Valley PC | Poughkeepsie | New York | 12603 | — |
| Associated Medical Professionals of New York, PLLC | Syracuse | New York | 13210 | — |
| Montefiore Medical Center - Montefiore Medical Park | The Bronx | New York | 10461 | — |
| TriState urologic Services PSC Inc., dba The Urology Group | Cincinnati | Ohio | 45212 | — |
| Clinical Research Solutions | Middleburg Heights | Ohio | 44130 | — |
| OU Health Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | — |
| Kaiser Sunnyside Medical Center | Clackamas | Oregon | 97015 | — |
| Kaiser Westside Medical Center | Hillsboro | Oregon | 97124 | — |
| Providence Cancer Institute Newberg Clinic | Newberg | Oregon | 97132 | — |
| Providence Newberg Medical Center | Newberg | Oregon | 97132 | — |
| Providence Cancer Institute Willamette Falls | Oregon City | Oregon | 97045 | — |
| Providence Cancer Institute Franz Clinic | Portland | Oregon | 97213 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Oncology and Hematology Care Clinic - Westside | Portland | Oregon | 97225 | — |
| Providence St Vincent Medical Center - Investigational Drug Service | Portland | Oregon | 97225 | — |
| Providence St Vincent Medical Center | Portland | Oregon | 97225 | — |
| Kaiser Permanente Northwest | Portland | Oregon | 97227 | — |
| UPMC Hillman Cancer Center - Altoona | Altoona | Pennsylvania | 16601 | — |
| UPMC Hillman Cancer Center - Upper St. Clair | Bethel Park | Pennsylvania | 15102 | — |
| UPMC Hillman Cancer Center - Arnold Palmer - Mt View | Greensburg | Pennsylvania | 15601 | — |
| Keystone Urology Specialists | Lancaster | Pennsylvania | 17604 | — |
| UPMC Hillman Cancer Center - Monroeville | Monroeville | Pennsylvania | 15146 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC Hillman Cancer Center - Passavant (HOA) | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC Hillman Cancer Center - Passavant (OHA) | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC Hillman Cancer Center - Northwest | Seneca | Pennsylvania | 16346 | — |
| UPMC Hillman Cancer Center - Uniontown | Uniontown | Pennsylvania | 15401 | — |
| UPMC Hillman Cancer Center - Washington | Washington | Pennsylvania | 15301 | — |
| Carolina Urologic Research Center | Myrtle Beach | South Carolina | 29572 | — |
| Tennessee Oncology PLLC | Chattanooga | Tennessee | 37404 | — |
| Tennessee Oncology, PLLC | Chattanooga | Tennessee | 37404 | — |
| Urology Associates P.C. | Nashville | Tennessee | 37209 | — |
| The Vanderbilt Clinic | Nashville | Tennessee | 37232 | — |
| Vanderbuilt University Medical Center, Department of Urology | Nashville | Tennessee | 37232 | — |
| Urology Austin PLLC | Austin | Texas | 78745 | — |
| Rio Grande Urology, P.A. | El Paso | Texas | 79912 | — |
| Houston Metro Urology | Houston | Texas | 77027 | — |
| Urology Austin, PLLC | Round Rock | Texas | 78681 | — |
| Baylor Scott & White Medical Center - Temple | Temple | Texas | 76508 | — |
| Farmington Health Center -University of Utah | Farmington | Utah | 84025 | — |
| Huntsman Cancer Hospital | Salt Lake City | Utah | 84112 | — |
| University of Utah, Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
| Redwood Health Center-University of Utah | Salt Lake City | Utah | 84119 | — |
| South Jordan Health Center -University of Utah | South Jordan | Utah | 84095 | — |
| Inova Schar Cancer Institute Infusion Pharmacy | Fairfax | Virginia | 22031 | — |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Swedish Cancer Institute | Seattle | Washington | 98104 | — |
| Swedish Medical Center | Seattle | Washington | 98122 | — |
| University of Wisconsin Clinical Science Center | Madison | Wisconsin | 53792 | — |
| University of Wisconsin Hospital & Clinics | Madison | Wisconsin | 53792 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 238 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03395197, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 14, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03395197 live on ClinicalTrials.gov.