Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise

ClinicalTrials.gov ID: NCT03419988

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Advanced age is the main risk factor for chronic diseases such as cardiovascular disease, type 2 diabetes, Alzheimer's disease and cancer. One reason may be due to decreased resistance to oxidative stress as antioxidant defenses and cell protection is reduced with aging. This has been shown in animal studies and also that the impairment can be somewhat restored with exercise. This will be the first study to test this in humans by comparing young and older inactive adults before and after an exercise intervention, a practical and cost-effective intervention that can have tremendous public health impact by lowering risk for disease and medical-related costs.

Study identification

NCT ID: NCT03419988
Recruitment status: Completed
Study type: Interventional
Phase: Not applicable
Lead sponsor: Northern Arizona University; Other
Enrollment: 46 participants

Conditions and interventions

Conditions

Aging

Interventions

Exercise Intervention Behavioral

Behavioral

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 1, 2017 (Actual)
Primary completion: May 30, 2020 (Actual)
Completion: Jun 30, 2020 (Actual)
Last update posted: Aug 26, 2020

2017 – 2020

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Northern Arizona University	Flagstaff	Arizona	86011	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03419988, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 26, 2020 · Synced Nov 15, 2026