ClinicalTrials.gov record
Study to Evaluate Efficacy and Safety of PF-04965842 With or Without Topical Medications in Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis
ClinicalTrials.gov ID: NCT03422822
Public ClinicalTrials.gov record NCT03422822. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3 MULTI-CENTER, LONG-TERM EXTENSION STUDY INVESTIGATING THE EFFICACY AND SAFETY OF ABROCITINIB, WITH OR WITHOUT TOPICAL MEDICATIONS, ADMINISTERED TO SUBJECTS AGED 12 YEARS AND OLDER WITH MODERATE TO SEVERE ATOPIC DERMATITIS
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
B7451015 is a Phase 3 study to evaluate Abrocitinib with or without Topical Medications in patients aged 12 years and older who have moderate to severe atopic dermatitis and have completed a qualifying parent study. The efficacy and safety of two dosage strengths of Abrocitinib, 100 mg and 200 mg taken orally once daily, will be evaluated over variable lengths of study participation. The study consists of a 92 week initial treatment period followed by a variable length secondary treatment period during which subjects will receive treatment with open-label abrocitinib until availability of commercial product in their country, or until the sponsor terminates the study in that country. The B7451015 study also includes a sub-study evaluating whether abrocitinib has any potential effects on adolescent bone with regard to abnormal bone findings in knee MRI. The sub-study will be conducted in selected countries at selected sites. Eligible subjects are those who were 12 to \<18 years of age at the screening visit of the qualifying parent study and who are currently participating in the main B7451015 study. The sub-study will include serial Magnetic Resonance Imaging (MRI) annually and continue until all enrolled subjects are 18 years of age and have been imaged at least once or have discontinued/withdrawn.
Study identification
- NCT ID
- NCT03422822
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 3,166 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 8, 2018 (Actual)
- Primary completion
- Dec 22, 2025 (Actual)
- Completion
- Dec 22, 2025 (Actual)
- Last update posted
- Jan 15, 2026
2018 – 2025
United States locations
- U.S. sites
- 156
- U.S. states
- 30
- U.S. cities
- 104
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Total Skin and Beauty Dermatology Center, PC | Birmingham | Alabama | 35205 | — |
| Clinical Research Center of Alabama, LLC | Birmingham | Alabama | 35209 | — |
| University of Alabama at Birmingham - Dermatology Research Clinic | Birmingham | Alabama | 35233 | — |
| University of Alabama at Birmingham Hospital Outreach Lab | Birmingham | Alabama | 35233 | — |
| Clinical Research Center of Alabama, LLC | Birmingham | Alabama | 35244 | — |
| The University of Alabama at Birmingham, Department of Dermatology | Birmingham | Alabama | 35294 | — |
| Emmaus Research Center, Inc. | Anaheim | California | 92804 | — |
| California Dermatology & Clinical Research Institute | Encinitas | California | 92024 | — |
| First OC Dermatology Research Inc | Fountain Valley | California | 92708 | — |
| Marvel Research, LLC | Huntington Beach | California | 92647 | — |
| Tilda Research Inc. | Irvine | California | 92612 | — |
| Beach Allergy and Asthma Specialty Group, A Medical Corporation | Long Beach | California | 90808 | — |
| Keck School of Medicine of University of Southern California | Los Angeles | California | 90033 | — |
| Wallace Medical Group, Inc | Los Angeles | California | 90056 | — |
| Allergy & Asthma Associates of Southern California dba Southern California Research | Mission Viejo | California | 92691 | — |
| Dermatology Specialists, Inc. | Oceanside | California | 92056 | — |
| Peninsula Headlands LLC | Rolling Hills Estates | California | 90274 | — |
| UC Davis Health | Sacramento | California | 95816 | — |
| MedDerm Associates | San Diego | California | 92103 | — |
| University of California San Diego Dermatology | San Diego | California | 92122 | — |
| Synergy Dermatology | San Francisco | California | 94132 | — |
| San Luis Dermatology and Laser Clinic | San Luis Obispo | California | 93405 | — |
| Southern California Dermatology, Inc. | Santa Ana | California | 92701 | — |
| Wolverine Clinical Trials, Llc | Santa Ana | California | 92705 | — |
| Mosaic Dermatology | Santa Monica | California | 90403 | — |
| Clinical Science Institute | Santa Monica | California | 90404 | — |
| Asthma and Allergy Associates, PC | Colorado Springs | Colorado | 80907 | — |
| Colorado Springs Dermatology Clinic, PC | Colorado Springs | Colorado | 80910 | — |
| Skin Care Research | Boca Raton | Florida | 33486 | — |
| Renaissance Research and Medical Group, Inc | Cape Coral | Florida | 33991 | — |
| Florida Academic Centers Research and Education, LLC | Coral Gables | Florida | 33134 | — |
| Skin Research Institute | Coral Gables | Florida | 33146 | — |
| Moonshine Research Center, Inc. | Doral | Florida | 33166 | — |
| Homestead Research Institute | Homestead | Florida | 33030 | — |
| Clinical Neuroscience Solutions, Inc. | Jacksonville | Florida | 32256 | — |
| Solutions Through Advanced Research, Inc. | Jacksonville | Florida | 32256 | — |
| C & R Research Services USA, Inc | Kendall | Florida | 33183 | — |
| Clinical Trials Solutions | Miami | Florida | 33126 | — |
| Global Health Clinical Trials Corp | Miami | Florida | 33135 | — |
| Baumann Cosmetic and Research Institute | Miami | Florida | 33137 | — |
| Suncoast Research Associates | Miami | Florida | 33144 | — |
| La Salud Research Clinic, Inc. | Miami | Florida | 33155 | — |
| Nicklaus Children's Hospital | Miami | Florida | 33155 | — |
| South Miami Medical & Research Group, Inc. | Miami | Florida | 33155 | — |
| Ciocca Dermatology, PA | Miami | Florida | 33173 | — |
| Miami Dermatology & Laser Research, LLC | Miami | Florida | 33173 | — |
| INTERMED Medical Research Center, Inc | Miami | Florida | 33175 | — |
| Suncoast Research Associates | Miami | Florida | 33184 | — |
| Savin Medical Group LLC | Miami Lakes | Florida | 33014 | — |
| Wellness Clinical Research, LLC | Miami Lakes | Florida | 33016 | — |
| Park Avenue Dermatology | Orange Park | Florida | 32073 | — |
| Clinical Neuroscience Solutions, Inc. | Orlando | Florida | 32801 | — |
| AdventHealth Orlando | Orlando | Florida | 32803 | — |
| AdventHealth Pediatric Dermatology Orlando | Orlando | Florida | 32803 | — |
| Advent Health Orlando - Investigational Drug Services | Orlando | Florida | 32804 | — |
| Outpatient Services Center - AdventHealth Orlando | Orlando | Florida | 32804 | — |
| Pediatric Outpatient Procedures and Sedation | Orlando | Florida | 32804 | — |
| Accel Research Sites - Nona Pediatric Center | Orlando | Florida | 32829 | — |
| Olympian Clinical Research | St. Petersburg | Florida | 33709 | — |
| Clinical Research Trials of Florida, Inc. | Tampa | Florida | 33607 | — |
| Clinical Research Trials of Florida | Tampa | Florida | 33607 | — |
| ForCare Clinical Research | Tampa | Florida | 33613 | — |
| University of South Florida; Asthma, Allergy and Immunology Clinical Research Unit | Tampa | Florida | 33613 | — |
| Olympian Clinical Research | Tampa | Florida | 33615 | — |
| Integrated Clinical Research | West Palm Beach | Florida | 33406 | — |
| Columbus Regional Research Institute | Columbus | Georgia | 31904 | — |
| IACT Health | Columbus | Georgia | 31904 | — |
| One Health Research Clinic Atlanta, LLC | Johns Creek | Georgia | 30097 | — |
| Dermatologic Surgery Specialists, PC | Macon | Georgia | 31217 | — |
| Meridian Clinical Research | Savannah | Georgia | 31406 | — |
| ASR, LLC | Nampa | Idaho | 83687 | — |
| Midwest Allergy Sinus Asthma, SC | Normal | Illinois | 61761 | — |
| NorthShore University HealthSystem - Dermatology | Skokie | Illinois | 60077 | — |
| NorthShore University HealthSystem Dermatology Clinical Trials Unit | Skokie | Illinois | 60077 | — |
| Dundee Dermatology | West Dundee | Illinois | 60118 | — |
| Ds Research | Clarksville | Indiana | 47129 | — |
| Dawes Fretzin Clinical Research Group, LLC | Indianapolis | Indiana | 46250 | — |
| The Indiana Clinical Trials Center | Plainfield | Indiana | 46168 | — |
| The South Bend Clinic Center for Research | South Bend | Indiana | 46617 | — |
| Kansas City Dermatology, PA | Overland Park | Kansas | 66215 | — |
| Skin Sciences, PLLC | Louisville | Kentucky | 40217 | — |
| Qualmedica Research, LLC. | Owensboro | Kentucky | 42301 | — |
| Owensboro Dermatology Associates | Owensboro | Kentucky | 42303 | — |
| Meridian Clinical Research, LLC | Baton Rouge | Louisiana | 70808 | — |
| Avant Research Associates LLC | Crowley | Louisiana | 70526 | — |
| Tulane University Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Institute for Asthma and Allergy | Chevy Chase | Maryland | 20815 | — |
| DermAssociates, LLC | Rockville | Maryland | 20850 | — |
| Chesapeake Clinical Research, Inc. | White Marsh | Maryland | 21162 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital - Clinical Unit for Research Trials in Skin (CURTIS) | Boston | Massachusetts | 02114 | — |
| MetroBoston Clinical Partners, LLC | Brighton | Massachusetts | 02135 | — |
| Clarkston Skin Research | Clarkston | Michigan | 48346 | — |
| Henry Ford Medical Center, New Center One | Detroit | Michigan | 48202 | — |
| Onyx Clinical Research | Flint | Michigan | 48507 | — |
| Hamzavi Dermatology | Fort Gratiot | Michigan | 48059 | — |
| Revival Research Institute, LLC | Troy | Michigan | 48084 | — |
| Somerset Skin Centre | Troy | Michigan | 48084 | — |
| Henry Ford Medical Center - Farmington Road | West Bloomfield | Michigan | 48322 | — |
| Clinical Research Institute, Inc. | Minneapolis | Minnesota | 55402 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| MediSearch Clinical Trials | Saint Joseph | Missouri | 64506 | — |
| Saint Louis University Dermatology | St Louis | Missouri | 63104 | — |
| Skin Specialists PC | Omaha | Nebraska | 68144 | — |
| Forest Hills Dermatology Group | Kew Gardens | New York | 11415 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| UR Dermatology Clinical Trials Unit at College Town | Rochester | New York | 14620 | — |
| Investigational Drug Service | Rochester | New York | 14642 | — |
| Cary Dermatology Center, PA | Cary | North Carolina | 27511 | — |
| Accellacare - Cary | Cary | North Carolina | 27518 | — |
| Medication Management, LLC | Greensboro | North Carolina | 27408 | — |
| M3-Wake Research, Inc. | Raleigh | North Carolina | 27612 | — |
| Carolina Research Center, Inc. | Shelby | North Carolina | 28150 | — |
| PMG Research of Wilmington LLC | Wilmington | North Carolina | 28411 | — |
| PMG Research of Wilmington, LLC | Wilmington | North Carolina | 28411 | — |
| PMG Research of Winston-Salem, LLC | Winston-Salem | North Carolina | 27103 | — |
| Winston-Salem Dermatology and Surgery Center, PLLC | Winston-Salem | North Carolina | 27103 | — |
| Bexley Dermatology Research | Bexley | Ohio | 43209 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| The Ohio State University Dermatology East | Gahanna | Ohio | 43230 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| Newton Clinical Research | Oklahoma City | Oklahoma | 73120 | — |
| Vital Prospects Clinical Research Institute, P.C. | Tulsa | Oklahoma | 74136 | — |
| Portland Clinical Research dba Columbia Asthma & Allergy Clinic | Clackamas | Oregon | 97015 | — |
| Velocity Clinical Research, Medford | Medford | Oregon | 97504 | — |
| Oregon Medical Research Center | Portland | Oregon | 97201 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Paddington Testing Co, Inc. | Philadelphia | Pennsylvania | 19103 | — |
| Synexus Clinical Research US, Inc. | Anderson | South Carolina | 29621 | — |
| MUSC SCTR Research Nexus Clinic and Laboratory | Charleston | South Carolina | 29425 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Tanenbaum Dermatology Center | Memphis | Tennessee | 38117 | — |
| Clinical Neuroscience Solutions, Inc. | Memphis | Tennessee | 38119 | — |
| International Clinical Research - Tennessee LLC | Murfreesboro | Tennessee | 37130 | — |
| Arlington Research Center, Inc. | Arlington | Texas | 76011 | — |
| The University of Texas Health Science Center Houston | Bellaire | Texas | 77401 | — |
| Menter Dermatology Research Institute | Dallas | Texas | 75246 | — |
| Center for Clinical Studies, LTD. LLP | Houston | Texas | 77004 | — |
| Ventavia Research Group | Hurst | Texas | 76054 | — |
| Austin Institute for Clinical Research, Inc. | Pflugerville | Texas | 78660 | — |
| Texas Dermatology and Laser Specialists | San Antonio | Texas | 78218 | — |
| Dermatology Clinical Research Center of San Antonio | San Antonio | Texas | 78229 | — |
| Center for Clinical Studies, LTD.LLP | Webster | Texas | 77598 | — |
| Summit Clinical Research, LLC | Franklin | Virginia | 23851 | — |
| Virginia Clinical Research, Inc | Norfolk | Virginia | 23502 | — |
| Virginia Dermatology and Skin Cancer Center | Norfolk | Virginia | 23502 | — |
| Fort Norfolk Diagnostic Center | Norfolk | Virginia | 23510 | — |
| Pace Dermatology Associates | Lakewood | Washington | 98499 | — |
| Dermatology Associates of Seattle | Seattle | Washington | 98101 | — |
| Dermatology Specialists of Spokane | Spokane | Washington | 99202 | — |
| Principle Research Solutions | Spokane | Washington | 99204 | — |
| MultiCare Allenmore Hospital | Tacoma | Washington | 98405 | — |
| Multicare Institute for Research and Innovation | Tacoma | Washington | 98405 | — |
| Pace Dermatology Associates | Tacoma | Washington | 98405 | — |
| Children's Hospital of Wisconsin Investigational Drug Service | Milwaukee | Wisconsin | 53226 | — |
| Children's Hospital of Wisconsin Translational Research Unit | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 383 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03422822, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 15, 2026 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03422822 live on ClinicalTrials.gov.