A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain
Public ClinicalTrials.gov record NCT03429049. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled, Single Injection, 52-Week Study to Evaluate the Efficacy and Safety of an Intra-articular Injection of CNTX-4975-05 in Subjects With Chronic, Moderate-to-severe Osteoarthritis Knee Pain
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a phase 3, randomized, double-blind, placebo-controlled, single injection, 52-week study to evaluate the analgesic efficacy and safety of a single intra-articular (IA) CNTX-4975-05 (capsaicin), compared to IA placebo, in subjects with chronic, moderate-to-severe osteoarthritis (OA) knee pain.
Study identification
- NCT ID
- NCT03429049
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 332 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years to 95 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 24, 2018 (Actual)
- Primary completion
- Nov 22, 2019 (Actual)
- Completion
- Nov 22, 2019 (Actual)
- Last update posted
- Jul 26, 2022
2018 – 2019
United States locations
- U.S. sites
- 33
- U.S. states
- 15
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Orthopaedic Center - Research | Birmingham | Alabama | 35209 | — |
| Cahaba Research, Inc | Birmingham | Alabama | 35242 | — |
| Coastal Clinical Research, Inc | Mobile | Alabama | 36608 | — |
| Noble Clinical Research, LLC | Tucson | Arizona | 85704 | — |
| Orange County Research Institute | Anaheim | California | 92801 | — |
| Core Healthcare Group | Cerritos | California | 90703 | — |
| Biosolutions Clinical Research Center | La Mesa | California | 91942 | — |
| Providence Clinical Research | North Hollywood | California | 91606 | — |
| Medical Associates Research Group | San Diego | California | 92123 | — |
| Encompass Clinical Research | Spring Valley | California | 91978 | — |
| Tampa Bay Medical Research, Inc | Clearwater | Florida | 33761 | — |
| Avail Clinical Research, LLC | DeLand | Florida | 32720 | — |
| M&M Medical Center, Inc | Miami | Florida | 33185 | — |
| Sensible Healthcare, LLC | Ocoee | Florida | 34761 | — |
| Jewett Orthopaedic | Orlando | Florida | 32822 | — |
| Clinical Research of West Florida, Inc. | Tampa | Florida | 33603 | — |
| Drug Studies America | Marietta | Georgia | 30060 | — |
| Georgia Institute for Clinical Research, LLC | Marietta | Georgia | 30060 | — |
| Atlanta Orthopaedic Institute, LLC | Stockbridge | Georgia | 30281 | — |
| MediSphere Medical Research Center, LLC | Evansville | Indiana | 47714 | — |
| Mid America PolyClinic | Overland Park | Kansas | 66210 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Tristan Medical Enterprises PC, dba | North Attleboro | Massachusetts | 02760 | — |
| Medical Research Associates, Inc | Traverse City | Michigan | 49686 | — |
| Sundance Clinical Research, LLC | St Louis | Missouri | 63141 | — |
| Clinical Research Consortium | Las Vegas | Nevada | 89119 | — |
| Hassman Research Institute | Berlin | New Jersey | 08009 | — |
| Bone Joint & Spine Surgeons, Inc | Toledo | Ohio | 43623 | — |
| Tekton Research, Inc | Austin | Texas | 78745 | — |
| Metroplex Clinical Research Center | Dallas | Texas | 75231 | — |
| Clinical Investigations of Texas | Plano | Texas | 75075 | — |
| Ortho Virginia | Arlington | Virginia | 22205 | — |
| Charlottesville Medical Research Center, LLC | Charlottesville | Virginia | 22911 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03429049, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 26, 2022 · Synced Oct 27, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03429049 live on ClinicalTrials.gov.