Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis
Public ClinicalTrials.gov record NCT03434028. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Multicenter, prospective, phase 3 randomized non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension. The aim of the study is to determine the impact of a restrictive fluids strategy (vasopressors first followed by rescue fluids) as compared to a liberal fluid strategy (fluids first followed by rescue vasopressors) on 90-day in-hospital mortality in patients with sepsis-induced hypotension.
Study identification
- NCT ID
- NCT03434028
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,563 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 7, 2018 (Actual)
- Primary completion
- May 10, 2022 (Actual)
- Completion
- Aug 24, 2022 (Actual)
- Last update posted
- Jul 6, 2023
2018 – 2022
United States locations
- U.S. sites
- 50
- U.S. states
- 23
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arizona | Tucson | Arizona | 85724 | — |
| UCSF Fresno | Fresno | California | 93701 | — |
| Ronald Reagan UCLA | Los Angeles | California | 90095 | — |
| UCSF San Francisco | San Francisco | California | 94143 | — |
| Stanford University Hospital | Stanford | California | 94305 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| Denver Health Medical Center | Denver | Colorado | 80204 | — |
| St. Joseph Hospital | Denver | Colorado | 80218 | — |
| Yale New Haven Hospital | New Haven | Connecticut | 06519 | — |
| Indiana University Health Methodist Hospital | Indianapolis | Indiana | 46202 | — |
| University of Kentucky | Lexington | Kentucky | 40506 | — |
| University Medical Center (LSU) | New Orleans | Louisiana | 70112 | — |
| Maine Medical Center | Portland | Maine | 04102 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Beth Israel Medical Center | Boston | Massachusetts | 02215 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02445 | — |
| Baystate Medical Center | Springfield | Massachusetts | 01199 | — |
| St. Vincent Hospital | Worcester | Massachusetts | 01608 | — |
| University of Michigan Medical Center | Ann Arbor | Michigan | 48109 | — |
| University of Minnesota Medical Center | Minneapolis | Minnesota | 55414 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Mt. Sinai Hospital | New York | New York | 10029 | — |
| Montefiore Medical Center | New York | New York | 10467 | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 30033 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Oregon Health and Science University OHSU | Portland | Oregon | 97239 | — |
| Penn State Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| UPMC Mercy | Pittsburgh | Pennsylvania | 15261 | — |
| UPMC Presbyterian | Pittsburgh | Pennsylvania | 15261 | — |
| UPMC Shadyside | Pittsburgh | Pennsylvania | 15261 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37221 | — |
| University of Texas Health Science Center | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| McKay-Dee Hospital | Ogden | Utah | 84403 | — |
| Utah Valley Regional Medical Center | Provo | Utah | 84604 | — |
| University of Utah Health Sciences Center | Salt Lake City | Utah | 84132 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| University Virginia Medical Center | Charlottesville | Virginia | 22903 | — |
| VCU Medical Center | Richmond | Virginia | 23298 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| University of Washington Medical Center | Seattle | Washington | 98104 | — |
| Swedish Hospital First Hill | Seattle | Washington | 98122 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03434028, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 6, 2023 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03434028 live on ClinicalTrials.gov.