A Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma
Public ClinicalTrials.gov record NCT03434379. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A Phase III, Open-Label, Randomized Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy and safety of atezolizumab in combination with bevacizumab compared with sorafenib in participants with locally advanced or metastatic Hepatocellular Carcinoma (HCC) who have received no prior systemic treatment.
Study identification
- NCT ID
- NCT03434379
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 558 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 15, 2018 (Actual)
- Primary completion
- Aug 31, 2020 (Actual)
- Completion
- Nov 17, 2022 (Actual)
- Last update posted
- Oct 23, 2023
2018 – 2022
United States locations
- U.S. sites
- 21
- U.S. states
- 13
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| St. Josephs Hospital and Medical Center | Phoenix | Arizona | 85260 | — |
| City of Hope | Duarte | California | 91010 | — |
| Uni of California - San Diego; Cancer Center & Dept of Medicine | La Jolla | California | 92093 | — |
| Kaiser Permanente Northern California | Novato | California | 94589 | — |
| University of California Irvine Medical Center | Orange | California | 92868 | — |
| Kaiser Permanente Sacramento Medical Center | Sacramento | California | 95825 | — |
| California Pacific Medical Center | San Francisco | California | 94115 | — |
| Kaiser Permanente - San Francisco Medical Center | San Francisco | California | 94118 | — |
| University of California Los Angeles | Santa Monica | California | 90404 | — |
| Kaiser Permanente - Walnut Creek | Walnut Creek | California | 94596 | — |
| Banner MD Anderson Cancer Center | Greeley | Colorado | 85234 | — |
| Georgetown University | Washington D.C. | District of Columbia | 20007 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Washington University; Wash Uni. Sch. Of Med | St Louis | Missouri | 63110 | — |
| University of New Mexico Comprehensive Cancer Center | Albuquerque | New Mexico | 87102 | — |
| Laura and ISAAC Perlmutter Cancer Center at NYU Langone. | New York | New York | 10016 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| M.D Anderson Cancer Center; Uni of Texas At Houston | Houston | Texas | 77030 | — |
| Swedish Cancer Inst. | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 98 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03434379, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 23, 2023 · Synced Nov 9, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03434379 live on ClinicalTrials.gov.