This Study Tests Empagliflozin in Patients With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF). The Study Looks at How Far Patients Can Walk in 6 Minutes and at Their Heart Failure Symptoms
Public ClinicalTrials.gov record NCT03448419. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Randomised, Double-blind Trial to Evaluate the Effect of 12 Weeks Treatment of Once Daily EMPagliflozin 10 mg Compared With Placebo on ExeRcise Ability and Heart Failure Symptoms, In Patients With Chronic HeArt FaiLure With Reduced Ejection Fraction (HFrEF) (EMPERIAL-reduced)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the study is to evaluate the effect of empagliflozin 10 mg versus placebo on exercise ability using the 6 minute walk test in patients with chronic HF with reduced ejection fraction (LVEF ≤ 40%) Secondary objectives are to assess Patient-Reported Outcome (PRO)
Study identification
- NCT ID
- NCT03448419
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 312 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 20, 2018 (Actual)
- Primary completion
- Sep 30, 2019 (Actual)
- Completion
- Oct 7, 2019 (Actual)
- Last update posted
- Nov 27, 2020
2018 – 2019
United States locations
- U.S. sites
- 41
- U.S. states
- 24
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mobile Heart Specialists, PC | Mobile | Alabama | 36608 | — |
| The Center for Clinical Trials, Inc. | Saraland | Alabama | 36571 | — |
| California Heart Specialists | Huntington Beach | California | 92648 | — |
| Manshadi Heart Institute, Inc | Stockton | California | 95204 | — |
| University of California Los Angeles | Torrance | California | 90502 | — |
| University of Colorado Denver | Aurora | Colorado | 80045 | — |
| Western Connecticut Health Network | Danbury | Connecticut | 06810 | — |
| Infinite Clinical Research | Miami | Florida | 33133 | — |
| Advance Medical Research Center | Miami | Florida | 33135 | — |
| Bio1 Clinical Research | Miami Beach | Florida | 33140 | — |
| Pharmacology Research, LLC | North Miami Beach | Florida | 33169 | — |
| Palm Beach Gardens Research Center, LLC | Palm Beach Gardens | Florida | 33410 | — |
| East Coast Institute for Research, LLC | Saint Augustine | Florida | 32086 | — |
| Cozy Research LLC | Zephyrhills | Florida | 33541 | — |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| Georgia Arrhythmia Consultants and Research Institute | Warner Robins | Georgia | 31093 | — |
| St Luke's Clinic - Idaho Cardiology Associates | Boise | Idaho | 83712 | — |
| Northwest Heart Clinical Research, LLC | Arlington Heights | Illinois | 60005 | — |
| Clinical Investigation Specialists, Inc | Gurnee | Illinois | 60031 | — |
| Chicago Medical Research | Hazel Crest | Illinois | 60429 | — |
| Midwest Heart and Vascular Specialists | Overland Park | Kansas | 66211 | — |
| Grace Research, LLC | Bossier City | Louisiana | 71111 | — |
| Grace Research, LLC | Shreveport | Louisiana | 71107 | — |
| Clinical Trials of America LA, LLC | West Monroe | Louisiana | 71291 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| University Of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Med Research One | Florissant | Missouri | 63031 | — |
| The DOCS | Las Vegas | Nevada | 89113 | — |
| Rutgers Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08901 | — |
| New York Heart Research Foundation, Inc. | Mineola | New York | 11501 | — |
| PMG Research of Rocky Mount, LLC | Rocky Mount | North Carolina | 27804 | — |
| PMG Research of Wilmington, LLC | Wilmington | North Carolina | 28401 | — |
| Rama Research LLC | Marion | Ohio | 43302 | — |
| Columbia Heart Clinic | Columbia | South Carolina | 29203 | — |
| Black Hills Cardiovascular Research | Rapid City | South Dakota | 57701 | — |
| The Jackson Clinic, PA | Jackson | Tennessee | 38301 | — |
| DiscoveResearch, Inc. | Beaumont | Texas | 77701 | — |
| Angiocardiac Care of Texas | Houston | Texas | 77025 | — |
| Mary Washington Hospital Research Department | Fredericksburg | Virginia | 22401 | — |
| York Clinical Research, LLC | Norfolk | Virginia | 23510 | — |
| Aspirus Research Institute | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 68 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03448419, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 27, 2020 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03448419 live on ClinicalTrials.gov.