Study To Evaluate the Efficacy, Safety and Tolerability of E2027 (Hereinafter Referred to as Irsenontrine) in Participants With Dementia With Lewy Bodies
Public ClinicalTrials.gov record NCT03467152. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Placebo-Controlled, Double-Blind, Parallel-Group, Randomized, Study To Evaluate the Efficacy, Safety and Tolerability of E2027 in Subjects With Dementia With Lewy Bodies
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will be conducted to compare Irsenontrine to placebo on the cognitive endpoint of Montreal Cognitive Assessment (MoCA) and the global clinical endpoint of Clinician's Interview Based Impression of Change Plus (CIBIC-Plus) Caregiver Input in participants with dementia with Lewy bodies after 12 weeks of treatment.
Study identification
- NCT ID
- NCT03467152
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 326 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 3, 2018
- Primary completion
- Apr 14, 2020
- Completion
- Apr 14, 2020
- Last update posted
- Jul 31, 2022
2018 – 2020
United States locations
- U.S. sites
- 25
- U.S. states
- 14
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| Advanced Research Center Inc | Anaheim | California | 92805 | — |
| Parkinsons and Movement Disorders Institute | Fountain Valley | California | 92708 | — |
| Paradigm Clinical Research Centers, Inc | San Diego | California | 92117 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| New England Institute for Clinical Research | Stamford | Connecticut | 06905 | — |
| Miami Jewish Health-Clinical Research | Miami | Florida | 33137 | — |
| Elias Research Associates (Allied Biomedical Research Institute) | Miami | Florida | 33155 | — |
| Pharmax Research of South Florida; Elias Research Associates | Miami | Florida | 33175 | — |
| Compass Research-Bioclinica | Orlando | Florida | 32806 | — |
| Neurology Associates of Ormond Beach | Ormond Beach | Florida | 32174 | — |
| Advanced Research Consultants, Inc. | Palm Beach Gardens | Florida | 33410 | — |
| Anchor Neuroscience | Pensacola | Florida | 32502 | — |
| Compass Research-Bioclinica | The Villages | Florida | 32162 | — |
| Indiana University, Dept of Neurology | Indianapolis | Indiana | 46202 | — |
| University of Kentucky, Dept of Neurology Sanders Brown Center on Aging | Lexington | Kentucky | 40504 | — |
| University of Michigan | Ann Arbor | Michigan | 48106 | — |
| Neurological Associates of Albany, PC | Albany | New York | 12208 | — |
| Columbia University | New York | New York | 10032 | — |
| PMG Research of Winston-Salem, LLC | Winston-Salem | North Carolina | 27103 | — |
| Cleveland Clinic, Lou Ruvo Center for Brain Health at Lakewood Hospital | Lakewood | Ohio | 44107 | — |
| Summit Research Network (Oregon) Inc. | Portland | Oregon | 97210 | — |
| New Orleans Center for Clinical Research | Knoxville | Tennessee | 37920 | — |
| Kerwin Research Center, LLC | Dallas | Texas | 75231-4350 | — |
| University of Virginia Adult Neurology | Charlottesville | Virginia | 22903 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 49 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03467152, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 31, 2022 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03467152 live on ClinicalTrials.gov.