Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS)

ClinicalTrials.gov ID: NCT03483051

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The current trial is designed to assess the safety and efficacy of sustained oral administration of inorganic nitrate in patients with severe aortic stenosis and to assess the mechanisms by which inorganic nitrate enhances oxygen uptake and exercise capacity in this population.

Study identification

NCT ID: NCT03483051
Recruitment status: Completed
Study type: Interventional
Phase: Phase 2
Lead sponsor: University of Pennsylvania; Other
Enrollment: 5 participants

Conditions and interventions

Conditions

Aortic Valve Stenosis

Interventions

Potassium Nitrate Drug
Potassium Chloride Drug

Drug

Eligibility (public fields only)

Age range: 50 Years to 90 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: May 1, 2018 (Actual)
Primary completion: Mar 13, 2019 (Actual)
Completion: May 23, 2019 (Actual)
Last update posted: Jun 17, 2020

2018 – 2019

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
University of Pennsylvania	Philadelphia	Pennsylvania	19104	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03483051, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jun 17, 2020 · Synced Nov 15, 2026