Lisocabtagene Maraleucel (JCAR017) as Second-Line Therapy (TRANSCEND-PILOT-017006)
Public ClinicalTrials.gov record NCT03483103. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Study of Lisocabtagene Maraleucel (JCAR017) as Second-Line Therapy in Adult Patients With Aggressive B-cell NHL (017006)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 2, open-label, multicenter study to determine the efficacy and safety of lisocabtagene maraleucel (JCAR017) in adult subjects who have relapsed from, or are refractory to, a single line of immunochemotherapy for aggressive B-cell non-Hodgkin lymphoma (NHL) and are ineligible for hematopoietic stem cell transplant (based on age, performance status, and/or comorbidities). Subjects will receive treatment with lisocabtagene maraleucel and will be followed for 2 years for safety, pharmacokinetics and biomarkers, disease status, quality of life, and survival.
Study identification
- NCT ID
- NCT03483103
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 74 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 27, 2018 (Actual)
- Primary completion
- Sep 24, 2021 (Actual)
- Completion
- Dec 1, 2022 (Actual)
- Last update posted
- Dec 20, 2023
2018 – 2022
United States locations
- U.S. sites
- 59
- U.S. states
- 17
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Local Institution - 0043 | Gilbert | Arizona | 85234 | — |
| Scripps Clinic | La Jolla | California | 92037 | — |
| UNC School of Medicine | Los Angeles | California | 90095 | — |
| University of California Los Angeles | Los Angeles | California | 90095 | — |
| Sutter Hematology and Oncology | Sacramento | California | 95816 | — |
| Sutter Medical Center | Sacramento | California | 95816 | — |
| Stanford Cancer Genetics Clinic | Stanford | California | 94304 | — |
| Local Institution - 0092 | Stanford | California | 94305 | — |
| Stanford Cancer Center | Stanford | California | 94305 | — |
| Local Institution - 0019 | Atlanta | Georgia | 30342 | — |
| The Blood and Marrow Transplant Group of Georgia | Atlanta | Georgia | 30342 | — |
| UNC School of Medicine | Atlanta | Georgia | 30342 | — |
| Local Institution - 0003 | Chicago | Illinois | 60611 | — |
| Northwestern University Feinberg School of Medicine | Chicago | Illinois | 60611 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Local Institution - 0016 | Chicago | Illinois | 60637-1470 | — |
| University of Chicago | Chicago | Illinois | 60637-1470 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Local Institution - 0046 | Lexington | Kentucky | 40536 | — |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Local Institution - 0064 | Louisville | Kentucky | 40241 | — |
| Norton Cancer Institute - Brownsboro | Louisville | Kentucky | 40241 | — |
| UNC School of Medicine | Louisville | Kentucky | 40241 | — |
| Johns Hopkins Oncology Center Bunting Blaustein Building | Baltimore | Maryland | 21231 | — |
| Local Institution - 0009 | Baltimore | Maryland | 21231 | — |
| The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | 21231 | — |
| Local Institution - 0052 | East Brunswick | New Jersey | 08816 | — |
| Regional Cancer Care Associates | East Brunswick | New Jersey | 08816 | — |
| UNC School of Medicine | East Brunswick | New Jersey | 08816 | — |
| New York Oncology Hematology - Albany Cancer Center | Albany | New York | 12208 | — |
| New York Oncology Hematology P.C. | Albany | New York | 12208 | — |
| Local Institution - 0090 | Rochester | New York | 14642 | — |
| University of Rochester Cancer Center | Rochester | New York | 14642 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | — |
| Local Institution - 0021 | Charlotte | North Carolina | 28204 | — |
| Local Institution - 0039 | Cincinnati | Ohio | 45236 | — |
| Oncology Hematology Care, Inc. | Cincinnati | Ohio | 45236 | — |
| Oncology Hematology Care | Cincinnati | Ohio | 45236 | — |
| Local Institution - 0051 | Portland | Oregon | 97213 | — |
| Providence Cancer Center/Earle A. Chiles Res. Inst. | Portland | Oregon | 97213 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Local Institution - 0029 | Pittsburgh | Pennsylvania | 15232 | — |
| University of Pittsburgh Medical Center Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Greenville Health System - Cancer Institute - Faris Road | Greenville | South Carolina | 29605 | — |
| Greenville Health System | Greenville | South Carolina | 29615 | — |
| Local Institution - 0037 | Greenville | South Carolina | 29615 | — |
| Local Institution - 0083 | Dallas | Texas | 75390-7208 | — |
| UNC School of Medicine | Dallas | Texas | 75390 | — |
| Intermountain Healthcare - LDS Hospital Blood and Marrow Transplant | Salt Lake City | Utah | 84143 | — |
| Intermountain Healthcare - LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Local Institution - 0074 | Salt Lake City | Utah | 84143 | — |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | — |
| UNC School of Medicine | Tacoma | Washington | 98405 | — |
| Local Institution - 0055 | Milwaukee | Wisconsin | 53226 | — |
| Medical College of Wisconsin, Froedtert Hospital | Milwaukee | Wisconsin | 53226 | — |
| UNC School of Medicine | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03483103, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 20, 2023 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03483103 live on ClinicalTrials.gov.