Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery

ClinicalTrials.gov ID: NCT03493425

Public ClinicalTrials.gov record NCT03493425. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 5:05 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase II Randomized Trial of Neo-Adjuvant Chemotherapy Followed by Surgery and Post-Operative Radiation Versus Surgery and Post-Operative Radiation for Organ Preservation of T3 and T4a Nasal and Paranasal Sinus Squamous Cell Carcinoma (NPNSCC)

Study identification

NCT ID: NCT03493425
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: ECOG-ACRIN Cancer Research Group; Network
Enrollment: 82 participants

Conditions and interventions

Conditions

Interventions

Carboplatin Drug
Cisplatin Drug
Docetaxel Drug
Image Guided Radiation Therapy Radiation
Intensity-Modulated Radiation Therapy Radiation
Laboratory Biomarker Analysis Other
Questionnaire Administration Other
Therapeutic Conventional Surgery Procedure

Drug · Radiation · Other + 1 more

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 11, 2019
Primary completion: Mar 30, 2029
Completion: Mar 30, 2029
Last update posted: May 4, 2026

2019 – 2029

United States locations

U.S. sites: 140
U.S. states: 28
U.S. cities: 106

Facility	City	State	ZIP	Site status
University of Arizona Cancer Center-Orange Grove Campus	Tucson	Arizona	85704	Recruiting
Banner University Medical Center - Tucson	Tucson	Arizona	85719	Recruiting
University of Arizona Cancer Center-North Campus	Tucson	Arizona	85719	Recruiting
Mercy Hospital Fort Smith	Fort Smith	Arkansas	72903	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92093	Withdrawn
Stanford Cancer Institute Palo Alto	Palo Alto	California	94304	Recruiting
VA Palo Alto Health Care System	Palo Alto	California	94304	Recruiting
Smilow Cancer Center/Yale-New Haven Hospital	New Haven	Connecticut	06510	Recruiting
Yale University	New Haven	Connecticut	06520	Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	33146	Suspended
UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	33442	Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	33324	Recruiting
Moffitt Cancer Center-International Plaza	Tampa	Florida	33607	Recruiting
Moffitt Cancer Center - McKinley Campus	Tampa	Florida	33612	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Emory Proton Therapy Center	Atlanta	Georgia	30308	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Recruiting
Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	30322	Recruiting
Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	83706	Recruiting
Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	83605	Recruiting
Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	83814	Recruiting
Idaho Urologic Institute-Meridian	Meridian	Idaho	83642	Recruiting
Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	83686	Recruiting
Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	83854	Recruiting
Rush - Copley Medical Center	Aurora	Illinois	60504	Recruiting
Northwestern University	Chicago	Illinois	60611	Active, not recruiting
Rush University Medical Center	Chicago	Illinois	60612	Recruiting
Carle on Vermilion	Danville	Illinois	61832	Recruiting
Carle Physician Group-Effingham	Effingham	Illinois	62401	Recruiting
NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	60201	Recruiting
NorthShore University HealthSystem-Glenbrook Hospital	Glenview	Illinois	60026	Recruiting
NorthShore University HealthSystem-Highland Park Hospital	Highland Park	Illinois	60035	Recruiting
Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	61938	Recruiting
Good Samaritan Regional Health Center	Mount Vernon	Illinois	62864	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Recruiting
The Carle Foundation Hospital	Urbana	Illinois	61801	Recruiting
Saint Anthony Regional Hospital	Carroll	Iowa	51401	Recruiting
Iowa Methodist Medical Center	Des Moines	Iowa	50309	Recruiting
Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	50309	Recruiting
Broadlawns Medical Center	Des Moines	Iowa	50314	Recruiting
Iowa Lutheran Hospital	Des Moines	Iowa	50316	Recruiting
Methodist West Hospital	West Des Moines	Iowa	50266-7700	Recruiting
Central Care Cancer Center - Garden City	Garden City	Kansas	67846	Recruiting
Central Care Cancer Center - Great Bend	Great Bend	Kansas	67530	Recruiting
University of Kansas Cancer Center	Kansas City	Kansas	66160	Active, not recruiting
Lawrence Memorial Hospital	Lawrence	Kansas	66044	Active, not recruiting
Olathe Health Cancer Center	Olathe	Kansas	66061	Active, not recruiting
University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	66210	Active, not recruiting
Ascension Via Christi - Pittsburg	Pittsburg	Kansas	66762	Active, not recruiting
Salina Regional Health Center	Salina	Kansas	67401	Active, not recruiting
University of Kansas Health System Saint Francis Campus	Topeka	Kansas	66606	Active, not recruiting
University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	66205	Active, not recruiting
The James Graham Brown Cancer Center at University of Louisville	Louisville	Kentucky	40202	Recruiting
Massachusetts General Hospital Cancer Center	Boston	Massachusetts	02114	Suspended
University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	48109	Recruiting
Henry Ford Cancer Institute-Downriver	Brownstown	Michigan	48183	Recruiting
Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	48038	Recruiting
Henry Ford Medical Center-Fairlane	Dearborn	Michigan	48126	Recruiting
Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	48201	Recruiting
Henry Ford Hospital	Detroit	Michigan	48202	Recruiting
Weisberg Cancer Treatment Center	Farmington Hills	Michigan	48334	Recruiting
Allegiance Health	Jackson	Michigan	49201	Recruiting
Henry Ford Medical Center-Columbus	Novi	Michigan	48377	Recruiting
Henry Ford Macomb Health Center - Shelby Township	Shelby	Michigan	48315	Recruiting
Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	48322	Recruiting
Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	56601	Recruiting
Saint Louis Cancer and Breast Institute-Ballwin	Ballwin	Missouri	63011	Recruiting
Central Care Cancer Center - Bolivar	Bolivar	Missouri	65613	Recruiting
Siteman Cancer Center at Saint Peters Hospital	City of Saint Peters	Missouri	63376	Recruiting
Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	63141	Recruiting
Freeman Health System	Joplin	Missouri	64804	Recruiting
Mercy Hospital Joplin	Joplin	Missouri	64804	Recruiting
University of Kansas Cancer Center - North	Kansas City	Missouri	64154	Active, not recruiting
University of Kansas Cancer Center at North Kansas City Hospital	North Kansas City	Missouri	64116	Active, not recruiting
Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	65401	Recruiting
Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	65401	Recruiting
Heartland Regional Medical Center	Saint Joseph	Missouri	64506	Recruiting
Mercy Hospital Springfield	Springfield	Missouri	65804	Recruiting
CoxHealth South Hospital	Springfield	Missouri	65807	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Mercy Hospital South	St Louis	Missouri	63128	Recruiting
Siteman Cancer Center-South County	St Louis	Missouri	63129	Recruiting
Siteman Cancer Center at Christian Hospital	St Louis	Missouri	63136	Recruiting
Mercy Hospital Saint Louis	St Louis	Missouri	63141	Recruiting
Billings Clinic Cancer Center	Billings	Montana	59101	Recruiting
Bozeman Deaconess Hospital	Bozeman	Montana	59715	Recruiting
Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	59405	Recruiting
Great Falls Clinic	Great Falls	Montana	59405	Recruiting
Kalispell Regional Medical Center	Kalispell	Montana	59901	Recruiting
Community Medical Hospital	Missoula	Montana	59804	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
Northwell Health Imbert Cancer Center	Bay Shore	New York	11706	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Recruiting
Northwell Health/Center for Advanced Medicine	Lake Success	New York	11042	Recruiting
Long Island Jewish Medical Center	New Hyde Park	New York	11040	Recruiting
Lenox Hill Hospital	New York	New York	10021	Recruiting
Mount Sinai Hospital	New York	New York	10029	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of Rochester	Rochester	New York	14642	Recruiting
Montefiore Medical Center-Einstein Campus	The Bronx	New York	10461	Recruiting
Montefiore Medical Center-Weiler Hospital	The Bronx	New York	10461	Recruiting
Montefiore Medical Center - Moses Campus	The Bronx	New York	10467	Recruiting
UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	27599	Recruiting
Sanford Bismarck Medical Center	Bismarck	North Dakota	58501	Recruiting
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Recruiting
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58122	Recruiting
University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	45219	Recruiting
University of Cincinnati Cancer Center-West Chester	West Chester	Ohio	45069	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Active, not recruiting
Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	73120	Recruiting
UPMC-Heritage Valley Health System Beaver	Beaver	Pennsylvania	15009	Recruiting
UPMC Cancer Centers - Arnold Palmer Pavilion	Greensburg	Pennsylvania	15601	Recruiting
UPMC Pinnacle Cancer Center/Community Osteopathic Campus	Harrisburg	Pennsylvania	17109	Recruiting
UPMC Jameson	New Castle	Pennsylvania	16105	Suspended
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
UPMC-Presbyterian Hospital	Pittsburgh	Pennsylvania	15213	Recruiting
University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	15232	Recruiting
UPMC-Shadyside Hospital	Pittsburgh	Pennsylvania	15232	Recruiting
UPMC-Passavant Hospital	Pittsburgh	Pennsylvania	15237	Recruiting
UPMC Washington Hospital Radiation Oncology	Washington	Pennsylvania	15301	Recruiting
Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	57104	Recruiting
Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	57117-5134	Recruiting
Parkland Memorial Hospital	Dallas	Texas	75235	Active, not recruiting
UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	75390	Active, not recruiting
UT Southwestern Clinical Center at Richardson/Plano	Richardson	Texas	75080	Active, not recruiting
Inova Schar Cancer Institute	Fairfax	Virginia	22031	Recruiting
Inova Fairfax Hospital	Falls Church	Virginia	22042	Recruiting
Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	54701	Recruiting
Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	54449	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Active, not recruiting
Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	54548	Recruiting
Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	54868	Recruiting
Marshfield Clinic Stevens Point Center	Stevens Point	Wisconsin	54482	Recruiting
Marshfield Clinic-Wausau Center	Wausau	Wisconsin	54401	Suspended
Diagnostic and Treatment Center	Weston	Wisconsin	54476	Recruiting
Marshfield Medical Center - Weston	Weston	Wisconsin	54476	Recruiting
Welch Cancer Center	Sheridan	Wyoming	82801	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03493425, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 4, 2026 · Synced May 8, 2026

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The complete protocol, eligibility criteria, and contact information for NCT03493425 live on ClinicalTrials.gov.

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