Effect of Efpeglenatide on Cardiovascular Outcomes
Public ClinicalTrials.gov record NCT03496298. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Effect of Efpeglenatide on Cardiovascular Outcomes in Type 2 Diabetes Patients at High Cardiovascular Risk
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Primary Objective: To demonstrate that efpeglenatide 4 and 6 mg was noninferior to placebo on 3-point major adverse cardiac events (MACE) in Type 2 diabetes mellitus (T2DM) participants at high cardiovascular (CV) risk. Secondary Objectives: To demonstrate that efpeglenatide 4 and 6 mg was superior to placebo in T2DM participants with high CV risk on the following parameters: * 3-point MACE. * Expanded CV outcome. * Composite outcome of new or worsening nephropathy. To assess the safety and tolerability of efpeglenatide 4 and 6 mg, both added to standard of care in T2DM participants at high CV risk.
Study identification
- NCT ID
- NCT03496298
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 4,076 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 27, 2018 (Actual)
- Primary completion
- Dec 10, 2020 (Actual)
- Completion
- Dec 10, 2020 (Actual)
- Last update posted
- Oct 15, 2021
2018 – 2020
United States locations
- U.S. sites
- 79
- U.S. states
- 33
- U.S. cities
- 72
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Investigational Site Number 8400032 | Sheffield | Alabama | 35660 | — |
| Investigational Site Number 8400014 | Gilbert | Arizona | 85295 | — |
| Investigational Site Number 8400012 | Surprise | Arizona | 85374 | — |
| Investigational Site Number 8400046 | Tucson | Arizona | 85745 | — |
| Investigational Site Number 8400022 | Beverly Hills | California | 90211 | — |
| Investigational Site Number 8400065 | Concord | California | 94520 | — |
| Investigational Site Number 8400060 | Greenbrae | California | 94904 | — |
| Investigational Site Number 8400084 | Long Beach | California | 90807 | — |
| Investigational Site Number 8400002 | Los Gatos | California | 95032 | — |
| Investigational Site Number 8400085 | Northridge | California | 91325 | — |
| Investigational Site Number 8400082 | Pomona | California | 91767 | — |
| Investigational Site Number 8400025 | Sacramento | California | 95821 | — |
| Investigational Site Number 8400064 | Englewood | Colorado | 80113 | — |
| Investigational Site Number 8400019 | Hamden | Connecticut | 06517 | — |
| Investigational Site Number 8400023 | Waterbury | Connecticut | 06708-3346 | — |
| Investigational Site Number 8400091 | Hialeah | Florida | 33012 | — |
| Investigational Site Number 8400040 | Hollywood | Florida | 33024 | — |
| Investigational Site Number 8400073 | Hudson | Florida | 34667 | — |
| Investigational Site Number 8400011 | Jacksonville | Florida | 32204 | — |
| Investigational Site Number 8400017 | Jacksonville | Florida | 32204 | — |
| Investigational Site Number 8400042 | Jacksonville | Florida | 32277 | — |
| Investigational Site Number 8400027 | Miami | Florida | 33126 | — |
| Investigational Site Number 8400051 | Miami | Florida | 33136 | — |
| Investigational Site Number 8400041 | New Port Richey | Florida | 34652 | — |
| Investigational Site Number 8400059 | Ormond Beach | Florida | 32174 | — |
| Investigational Site Number 8400006 | Macon | Georgia | 31210-1359 | — |
| Investigational Site Number 8400008 | Roswell | Georgia | 30076 | — |
| Investigational Site Number 8400081 | Idaho Falls | Idaho | 83404 | — |
| Investigational Site Number 8400095 | Arlington Heights | Illinois | 60005 | — |
| Investigational Site Number 8400070 | Chicago | Illinois | 60607 | — |
| Investigational Site Number 8400036 | Crystal Lake | Illinois | 60012 | — |
| Investigational Site Number 8400030 | New Albany | Indiana | 46113 | — |
| Investigational Site Number 8400074 | Topeka | Kansas | 66606 | — |
| Investigational Site Number 8400077 | Owensboro | Kentucky | 42303 | — |
| Investigational Site Number 8400043 | Paris | Kentucky | 40361 | — |
| Investigational Site Number 8400034 | Alexandria | Louisiana | 71301 | — |
| Investigational Site Number 8400079 | Monroe | Louisiana | 71203 | — |
| Investigational Site Number 8400013 | New Orleans | Louisiana | 70112 | — |
| Investigational Site Number 8400047 | Oxon Hill | Maryland | 20745 | — |
| Investigational Site Number 8400001 | Flint | Michigan | 48504 | — |
| Investigational Site Number 8400061 | Flint | Michigan | 48532-3447 | — |
| Investigational Site Number 8400010 | Troy | Michigan | 48085 | — |
| Investigational Site Number 8400005 | Troy | Michigan | 48098 | — |
| Investigational Site Number 8400024 | Saint Paul | Minnesota | 55102 | — |
| Investigational Site Number 8400045 | St Louis | Missouri | 63136 | — |
| Investigational Site Number 8400071 | Billings | Montana | 59103 | — |
| Investigational Site Number 8400028 | Great Falls | Montana | 59405-4507 | — |
| Investigational Site Number 8400086 | Kalispell | Montana | 59901 | — |
| Investigational Site Number 8400037 | Las Vegas | Nevada | 89128 | — |
| Investigational Site Number 8400087 | Raritan | New Jersey | 08869 | — |
| Investigational Site Number 8400056 | Staten Island | New York | 10301 | — |
| Investigational Site Number 8400018 | The Bronx | New York | 00000 | — |
| Investigational Site Number 8400076 | Greenville | North Carolina | 27834-5704 | — |
| Investigational Site Number 8400007 | Morehead City | North Carolina | 28557 | — |
| Investigational Site Number 8400093 | Morehead City | North Carolina | 28557 | — |
| Investigational Site Number 8400094 | Morganton | North Carolina | 28655 | — |
| Investigational Site Number 8400029 | Fargo | North Dakota | 58104 | — |
| Investigational Site Number 8400031 | Columbus | Ohio | 43203 | — |
| Investigational Site Number 8400078 | Lorain | Ohio | 44053 | — |
| Investigational Site Number 8400072 | Bend | Oregon | 97702 | — |
| Investigational Site Number 8400067 | Beaver | Pennsylvania | 15009-1957 | — |
| Investigational Site Number 8400096 | Philadelphia | Pennsylvania | 19107 | — |
| Investigational Site Number 8400021 | Pittsburgh | Pennsylvania | 15212 | — |
| Investigational Site Number 8400015 | Greer | South Carolina | 29651 | — |
| Investigational Site Number 8400063 | Murrells Inlet | South Carolina | 29576 | — |
| Investigational Site Number 8400044 | Rapid City | South Dakota | 57702 | — |
| Investigational Site Number 8400016 | Memphis | Tennessee | 38163 | — |
| Investigational Site Number 8400009 | Nashville | Tennessee | 37203 | — |
| Investigational Site Number 8400055 | Corpus Christi | Texas | 78814 | — |
| Investigational Site Number 8400097 | Dallas | Texas | 75230 | — |
| Investigational Site Number 8400088 | El Paso | Texas | 79935 | — |
| Investigational Site Number 8400058 | Fort Worth | Texas | 76132 | — |
| Investigational Site Number 8400069 | Houston | Texas | 77004 | — |
| Investigational Site Number 8400089 | Houston | Texas | 77030 | — |
| Investigational Site Number 8400092 | Richmond | Texas | 77469 | — |
| Investigational Site Number 8400033 | Waco | Texas | 76710 | — |
| Investigational Site Number 8400039 | Salt Lake City | Utah | 84102 | — |
| Investigational Site Number 8400052 | Norfolk | Virginia | 23510 | — |
| Investigational Site Number 8400049 | Manitowoc | Wisconsin | 54220 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 274 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03496298, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 15, 2021 · Synced Oct 31, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03496298 live on ClinicalTrials.gov.