A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)
Public ClinicalTrials.gov record NCT03496623. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Placebo-controlled, Double-blind, Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Patients With Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (PH-COPD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to demonstrate the efficacy of inhaled treprostinil compared to placebo in improving exercise ability as measured by change from baseline in 6-Minute Walk Distance (6MWD) following 12 weeks of active treatment in participants with PH-COPD.
Study identification
- NCT ID
- NCT03496623
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 188 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 8, 2018 (Actual)
- Primary completion
- Oct 13, 2022 (Actual)
- Completion
- Oct 13, 2022 (Actual)
- Last update posted
- Nov 24, 2023
2018 – 2022
United States locations
- U.S. sites
- 65
- U.S. states
- 26
- U.S. cities
- 56
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Banner University Medical Center | Phoenix | Arizona | 85006 | — |
| University of Arizona Clinical and Translational Science (CATS) Research Center | Tucson | Arizona | 85724 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| West Los Angeles VA Healthcare Center | Los Angeles | California | 90073 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| Santa Barbara Pulmonary Associates | Santa Barbara | California | 93102 | — |
| University of Colorado Health Sciences Center | Aurora | Colorado | 80045 | — |
| South Denver Cardiology | Littleton | Colorado | 80120 | — |
| Hartford Hospital | Hartford | Connecticut | 06106 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| St. Francis Medical Institute | Clearwater | Florida | 33765 | — |
| University of Florida Clinical Research Center | Gainesville | Florida | 32610 | — |
| St. Vincent's Lung, Sleep, and Critical Care Specialists | Jacksonville | Florida | 32204 | — |
| Mayo Clinic - Jacksonville | Jacksonville | Florida | 32224 | — |
| Pulmonary Disease Specialists | Kissimmee | Florida | 34741 | — |
| University of Miami Hospital | Miami | Florida | 33136 | — |
| University of South Florida | Tampa | Florida | 33606 | — |
| Pulmonary & Critical Care of Atlanta | Atlanta | Georgia | 30342 | — |
| Georgia Clinical Research | Austell | Georgia | 30106 | — |
| University of Illinois Medical Center | Chicago | Illinois | 60612 | — |
| Advocate Aurora Health Care | Elmhurst | Illinois | 60126 | — |
| Advocate Condell Medical Center | Libertyville | Illinois | 60048 | — |
| Advocate Heart Institute & Pulmonology | Normal | Illinois | 06176 | — |
| Edward Heart Hospital | Oakbrook Terrace | Illinois | 60181 | — |
| Indiana University Healh North Hospital | Indianapolis | Indiana | 46202 | — |
| St. Vincent Medical Group, Inc. | Indianapolis | Indiana | 46260 | — |
| University of Kentucky Medical Center | Lexington | Kentucky | 40536 | — |
| Kentuckiana Pulmonary Associates | Louisville | Kentucky | 40202 | — |
| University of Louisville Research Foundation | Louisville | Kentucky | 40202 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Detroit Medical Center Lung Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Spectrum Health | Grand Rapids | Michigan | 49546 | — |
| Beaumont Health | Troy | Michigan | 48085 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| The University of New Mexico | Albuquerque | New Mexico | 87106 | — |
| Albany Medical College | Albany | New York | 12208 | — |
| The Mount Sinai Hospital | New York | New York | 10029 | — |
| University of Rochester Medical Center | Rochester | New York | 14623 | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27517 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| The Carl and Edyth Lindner Research Center at the Christ Hospital | Cincinnati | Ohio | 45219 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Clinical Research Associates of Central PA, LLC | DuBois | Pennsylvania | 15801 | — |
| Temple Lung Center | Philadelphia | Pennsylvania | 19140 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| University of Pittsburgh Medical Center - Montefiore | Pittsburgh | Pennsylvania | 15213 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Statcare Pulmonary Consultants | Knoxville | Tennessee | 37909 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Texas Tech | El Paso | Texas | 79905 | — |
| Clear Lake Specialties/Tranquility Research | Webster | Texas | 77598 | — |
| Inova Fairfax Hospital | Falls Church | Virginia | 22042 | — |
| Pulmonary Associates of Richmond, Inc. | Richmond | Virginia | 23230 | — |
| Carilion Clinic | Roanoke | Virginia | 24014 | — |
| University of Wisconsin School of Medicine and Public Health | Madison | Wisconsin | 53792 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 11 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03496623, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 24, 2023 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03496623 live on ClinicalTrials.gov.