ClinicalTrials.gov record
Active, not recruiting Phase 2 Interventional

Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease

ClinicalTrials.gov ID: NCT03516279

Public ClinicalTrials.gov record NCT03516279. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 10, 2026, 9:41 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase II Study of Adding the Anti-PD-1 Pembrolizumab to Tyrosine Kinase Inhibitors in Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease

Study identification

NCT ID
NCT03516279
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
ECOG-ACRIN Cancer Research Group
Network
Enrollment
40 participants

Conditions and interventions

Interventions

  • Dasatinib Drug
  • Imatinib Mesylate Drug
  • Laboratory Biomarker Analysis Other
  • Nilotinib Drug
  • Pembrolizumab Biological

Drug · Other · Biological

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 25, 2019
Primary completion
Aug 30, 2028
Completion
Aug 30, 2031
Last update posted
Apr 2, 2026

2019 – 2031

United States locations

U.S. sites
291
U.S. states
33
U.S. cities
212
Facility City State ZIP Site status
Fairbanks Memorial Hospital Fairbanks Alaska 99701
CTCA at Western Regional Medical Center Goodyear Arizona 85338
Cancer Center at Saint Joseph's Phoenix Arizona 85004
Mercy Hospital Fort Smith Fort Smith Arkansas 72903
CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas 71913
CARTI Cancer Center Little Rock Arkansas 72205
Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande California 93420
Mercy Cancer Center - Carmichael Carmichael California 95608
Mercy San Juan Medical Center Carmichael California 95608
Mercy Cancer Center - Elk Grove Elk Grove California 95758
Contra Costa Regional Medical Center Martinez California 94553-3156
Mercy Cancer Center Merced California 95340
Mercy Cancer Center - Rocklin Rocklin California 95765
Mercy Cancer Center - Sacramento Sacramento California 95816
Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California 93401
Mission Hope Medical Oncology - Santa Maria Santa Maria California 93444
BASS Medical Group - Lennon Walnut Creek California 94598
Woodland Memorial Hospital Woodland California 95695
Rocky Mountain Cancer Centers-Aurora Aurora Colorado 80012
Boulder Community Foothills Hospital Boulder Colorado 80303
Rocky Mountain Cancer Centers-Boulder Boulder Colorado 80304
Rocky Mountain Cancer Centers - Centennial Centennial Colorado 80112
Penrose-Saint Francis Healthcare Colorado Springs Colorado 80907
Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado 80907
Saint Francis Cancer Center Colorado Springs Colorado 80923
The Women's Imaging Center Denver Colorado 80209
Porter Adventist Hospital Denver Colorado 80210
Colorado Blood Cancer Institute Denver Colorado 80218
Presbyterian - Saint Lukes Medical Center - Health One Denver Colorado 80218
Rocky Mountain Cancer Centers-Midtown Denver Colorado 80218
Rocky Mountain Cancer Centers-Rose Denver Colorado 80220
Rose Medical Center Denver Colorado 80220
Mercy Medical Center Durango Colorado 81301
Southwest Oncology PC Durango Colorado 81301
Mountain Blue Cancer Care Center - Swedish Englewood Colorado 80113
Rocky Mountain Cancer Centers - Swedish Englewood Colorado 80113
Swedish Medical Center Englewood Colorado 80113
The Melanoma and Skin Cancer Institute Englewood Colorado 80113
Mountain Blue Cancer Care Center Golden Colorado 80401
Rocky Mountain Cancer Centers-Lakewood Lakewood Colorado 80228
Saint Anthony Hospital Lakewood Colorado 80228
Rocky Mountain Cancer Centers-Littleton Littleton Colorado 80120
Littleton Adventist Hospital Littleton Colorado 80122
Rocky Mountain Cancer Centers-Sky Ridge Lone Tree Colorado 80124
Longmont United Hospital Longmont Colorado 80501
Rocky Mountain Cancer Centers-Longmont Longmont Colorado 80501
Parker Adventist Hospital Parker Colorado 80138
Rocky Mountain Cancer Centers-Parker Parker Colorado 80138
Saint Mary Corwin Medical Center Pueblo Colorado 81004
Rocky Mountain Cancer Centers - Pueblo Pueblo Colorado 81008
Rocky Mountain Cancer Centers-Thornton Thornton Colorado 80260
Smilow Cancer Hospital-Derby Care Center Derby Connecticut 06418
Smilow Cancer Hospital Care Center-Fairfield Fairfield Connecticut 06824
Smilow Cancer Hospital Care Center at Glastonbury Glastonbury Connecticut 06033
Smilow Cancer Hospital Care Center - Guilford Guilford Connecticut 06437
Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut 06105
Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut 06510
Yale University New Haven Connecticut 06520
Yale-New Haven Hospital North Haven Medical Center North Haven Connecticut 06473
Smilow Cancer Hospital-Torrington Care Center Torrington Connecticut 06790
Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut 06611
Smilow Cancer Hospital-Waterbury Care Center Waterbury Connecticut 06708
Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut 06385
Beebe South Coastal Health Campus Frankford Delaware 19945
Beebe Medical Center Lewes Delaware 19958
Delaware Clinical and Laboratory Physicians PA Newark Delaware 19713
Helen F Graham Cancer Center Newark Delaware 19713
Medical Oncology Hematology Consultants PA Newark Delaware 19713
Christiana Care Health System-Christiana Hospital Newark Delaware 19718
Beebe Health Campus Rehoboth Beach Delaware 19971
TidalHealth Nanticoke / Allen Cancer Center Seaford Delaware 19973
Christiana Care Health System-Wilmington Hospital Wilmington Delaware 19801
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814
Walter Knox Memorial Hospital Emmett Idaho 83617
Idaho Urologic Institute-Meridian Meridian Idaho 83642
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864
Saint Anthony's Health Alton Illinois 62002
Rush - Copley Medical Center Aurora Illinois 60504
Illinois CancerCare-Bloomington Bloomington Illinois 61704
Illinois CancerCare-Canton Canton Illinois 61520
Memorial Hospital of Carbondale Carbondale Illinois 62902
SIH Cancer Institute Carterville Illinois 62918
Illinois CancerCare-Carthage Carthage Illinois 62321
Centralia Oncology Clinic Centralia Illinois 62801
Saint Mary's Hospital Centralia Illinois 62801
Northwestern University Chicago Illinois 60611
University of Illinois Chicago Illinois 60612
Carle at The Riverfront Danville Illinois 61832
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526
Decatur Memorial Hospital Decatur Illinois 62526
Illinois CancerCare-Dixon Dixon Illinois 61021
Carle Physician Group-Effingham Effingham Illinois 62401
Crossroads Cancer Center Effingham Illinois 62401
Illinois CancerCare-Eureka Eureka Illinois 61530
Illinois CancerCare-Galesburg Galesburg Illinois 61401
Western Illinois Cancer Treatment Center Galesburg Illinois 61401
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045
Illinois CancerCare-Macomb Macomb Illinois 61455
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938
Good Samaritan Regional Health Center Mount Vernon Illinois 62864
Cancer Care Center of O'Fallon O'Fallon Illinois 62269
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350
Illinois CancerCare-Pekin Pekin Illinois 61554
Illinois CancerCare-Peoria Peoria Illinois 61615
Methodist Medical Center of Illinois Peoria Illinois 61636
Illinois CancerCare-Peru Peru Illinois 61354
Valley Radiation Oncology Peru Illinois 61354
Illinois CancerCare-Princeton Princeton Illinois 61356
Southern Illinois University School of Medicine Springfield Illinois 62702
Springfield Clinic Springfield Illinois 62702
Memorial Medical Center Springfield Illinois 62781
Southwest Illinois Health Services LLP Swansea Illinois 62226
Carle Cancer Center Urbana Illinois 61801
The Carle Foundation Hospital Urbana Illinois 61801
Illinois CancerCare - Washington Washington Illinois 61571
Rush-Copley Healthcare Center Yorkville Illinois 60560
Mary Greeley Medical Center Ames Iowa 50010
McFarland Clinic - Ames Ames Iowa 50010
Mission Cancer and Blood - Ankeny Ankeny Iowa 50023
McFarland Clinic - Boone Boone Iowa 50036
Saint Anthony Regional Hospital Carroll Iowa 51401
Mercy Cancer Center-West Lakes Clive Iowa 50325
Mission Cancer and Blood - West Des Moines Clive Iowa 50325
Alegent Health Mercy Hospital Council Bluffs Iowa 51503
Greater Regional Medical Center Creston Iowa 50801
Iowa Methodist Medical Center Des Moines Iowa 50309
Mission Cancer and Blood - Des Moines Des Moines Iowa 50309
Broadlawns Medical Center Des Moines Iowa 50314
Mercy Medical Center - Des Moines Des Moines Iowa 50314
Mission Cancer and Blood - Laurel Des Moines Iowa 50314
Iowa Lutheran Hospital Des Moines Iowa 50316
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501
Trinity Regional Medical Center Fort Dodge Iowa 50501
McFarland Clinic - Jefferson Jefferson Iowa 50129
McFarland Clinic - Marshalltown Marshalltown Iowa 50158
Methodist West Hospital West Des Moines Iowa 50266-7700
Mercy Medical Center-West Lakes West Des Moines Iowa 50266
Central Care Cancer Center - Garden City Garden City Kansas 67846
Central Care Cancer Center - Great Bend Great Bend Kansas 67530
Lawrence Memorial Hospital Lawrence Kansas 66044
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas 67208
Ascension Via Christi Hospitals Wichita Wichita Kansas 67214
Cancer Center of Kansas - Wichita Wichita Kansas 67214
Wesley Medical Center Wichita Kansas 67214
Flaget Memorial Hospital Bardstown Kentucky 40004
Commonwealth Cancer Center-Corbin Corbin Kentucky 40701
Saint Joseph Hospital Lexington Kentucky 40504
Saint Joseph Radiation Oncology Resource Center Lexington Kentucky 40504
Saint Joseph Hospital East Lexington Kentucky 40509
Saint Joseph London London Kentucky 40741
Jewish Hospital Louisville Kentucky 40202
Saints Mary and Elizabeth Hospital Louisville Kentucky 40215
UofL Health Medical Center Northeast Louisville Kentucky 40245
Saint Joseph Mount Sterling Mount Sterling Kentucky 40353
Mercy Health - Paducah Medical Oncology and Hematology Paducah Kentucky 42003
Jewish Hospital Medical Center South Shepherdsville Kentucky 40165
Saint Agnes Hospital Baltimore Maryland 21229
Hickman Cancer Center Adrian Michigan 49221
Toledo Clinic Cancer Centers-Monroe Monroe Michigan 48162
Mayo Clinic in Rochester Rochester Minnesota 55905
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303
Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri 63011
Central Care Cancer Center - Bolivar Bolivar Missouri 65613
Parkland Health Center-Bonne Terre Bonne Terre Missouri 63628
Cox Cancer Center Branson Branson Missouri 65616
Saint Francis Medical Center Cape Girardeau Missouri 63703
Southeast Cancer Center Cape Girardeau Missouri 63703
Saint Luke's Hospital Chesterfield Missouri 63017
Parkland Health Center - Farmington Farmington Missouri 63640
MU Health Care Goldschmidt Cancer Center Jefferson City Missouri 65109
Freeman Health System Joplin Missouri 64804
Mercy Hospital Joplin Joplin Missouri 64804
Lake Regional Hospital Osage Beach Missouri 65065
Delbert Day Cancer Institute at PCRMC Rolla Missouri 65401
Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri 65401
Heartland Regional Medical Center Saint Joseph Missouri 64506
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670
Mercy Hospital Springfield Springfield Missouri 65804
CoxHealth South Hospital Springfield Missouri 65807
Saint Louis Cancer and Breast Institute-South City St Louis Missouri 63109
Mercy Hospital South St Louis Missouri 63128
Missouri Baptist Medical Center St Louis Missouri 63131
Mercy Hospital Saint Louis St Louis Missouri 63141
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080
BJC Outpatient Center at Sunset Hills Sunset Hills Missouri 63127
Mercy Hospital Washington Washington Missouri 63090
Community Hospital of Anaconda Anaconda Montana 59711
Billings Clinic Cancer Center Billings Montana 59101
Bozeman Health Deaconess Hospital Bozeman Montana 59715
Benefis Sletten Cancer Institute Great Falls Montana 59405
Great Falls Clinic Great Falls Montana 59405
Saint Peter's Community Hospital Helena Montana 59601
Kalispell Regional Medical Center Kalispell Montana 59901
Community Medical Center Missoula Montana 59804
Nebraska Medicine-Bellevue Bellevue Nebraska 68123
Nebraska Cancer Specialists/Oncology Hematology West PC Grand Island Nebraska 68803
Heartland Hematology and Oncology Kearney Nebraska 68845
CHI Health Good Samaritan Kearney Nebraska 68847
Saint Elizabeth Regional Medical Center Lincoln Nebraska 68510
Nebraska Medicine-Village Pointe Omaha Nebraska 68118
Alegent Health Immanuel Medical Center Omaha Nebraska 68122
Hematology and Oncology Consultants PC Omaha Nebraska 68122
Alegent Health Bergan Mercy Medical Center Omaha Nebraska 68124
Alegent Health Lakeside Hospital Omaha Nebraska 68130
Creighton University Medical Center Omaha Nebraska 68131
University of Nebraska Medical Center Omaha Nebraska 68198
Midlands Community Hospital Papillion Nebraska 68046
Morristown Medical Center Morristown New Jersey 07960
Overlook Hospital Summit New Jersey 07902
Garnet Health Medical Center Middletown New York 10940
Southeastern Medical Oncology Center-Clinton Clinton North Carolina 28328
Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina 27534
Wayne Memorial Hospital Goldsboro North Carolina 27534
Onslow Memorial Hospital Jacksonville North Carolina 28546
Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina 28546
Good Samaritan Hospital - Cincinnati Cincinnati Ohio 45220
Bethesda North Hospital Cincinnati Ohio 45242
TriHealth Cancer Institute-Westside Cincinnati Ohio 45247
TriHealth Cancer Institute-Anderson Cincinnati Ohio 45255
MetroHealth Medical Center Cleveland Ohio 44109
Toledo Clinic Cancer Centers-Maumee Maumee Ohio 43537
Mercy Health Perrysburg Cancer Center Perrysburg Ohio 43551
Mercy Health - Saint Anne Hospital Toledo Ohio 43623
Toledo Clinic Cancer Centers-Toledo Toledo Ohio 43623
Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma 73505
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104
Mercy Hospital Oklahoma City Oklahoma City Oklahoma 73120
Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma 74146
Saint Alphonsus Cancer Care Center-Baker City Baker City Oregon 97814
Saint Alphonsus Cancer Care Center-Ontario Ontario Oregon 97914
Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania 19317
Geisinger Medical Center Danville Pennsylvania 17822
Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania 18201
Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania 17837
Lewistown Hospital Lewistown Pennsylvania 17044
Geisinger Cancer Services-Pottsville Pottsville Pennsylvania 17901
Community Medical Center Scranton Pennsylvania 18510
Geisinger Medical Oncology-Selinsgrove Selinsgrove Pennsylvania 17870
Geisinger Medical Group State College Pennsylvania 16801
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316
Prisma Health Cancer Institute - Laurens Clinton South Carolina 29325
Prisma Health Cancer Institute - Easley Easley South Carolina 29640
BI-LO Charities Children's Cancer Center Greenville South Carolina 29605
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605
Prisma Health Greenville Memorial Hospital Greenville South Carolina 29605
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615
Prisma Health Cancer Institute - Greer Greer South Carolina 29650
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672
Memorial Hospital Chattanooga Tennessee 37404
Vanderbilt-Ingram Cancer Center Cool Springs Franklin Tennessee 37067
Pulmonary Medicine Center of Chattanooga-Hixson Hixson Tennessee 37343
Vanderbilt Breast Center at One Hundred Oaks Nashville Tennessee 37204
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232
Memorial GYN Plus Ooltewah Tennessee 37363
Saint Joseph Regional Cancer Center Bryan Texas 77802
Sovah Health Martinsville Martinsville Virginia 24112
Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington 98310
Highline Medical Center-Main Campus Burien Washington 98166
Saint Elizabeth Hospital Enumclaw Washington 98022
Saint Francis Hospital Federal Way Washington 98003
Saint Clare Hospital Lakewood Washington 98499
Jefferson Healthcare Port Townsend Washington 98368
Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo Washington 98370
Saint Michael Cancer Center Silverdale Washington 98383
Franciscan Research Center-Northwest Medical Plaza Tacoma Washington 98405
Northwest Medical Specialties PLLC Tacoma Washington 98405
West Virginia University Healthcare Morgantown West Virginia 26506
ThedaCare Regional Cancer Center Appleton Wisconsin 54911
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701
Mayo Clinic Health System-Eau Claire Clinic Eau Claire Wisconsin 54701
Mayo Clinic Health System Eau Claire Hospital-Luther Campus Eau Claire Wisconsin 54703
Marshfield Medical Center - Ladysmith Ladysmith Wisconsin 54848
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449
Medical College of Wisconsin Milwaukee Wisconsin 53226
Marshfield Clinic-Minocqua Center Minocqua Wisconsin 54548
Froedtert and MCW Moorland Reserve Health Center New Berlin Wisconsin 53151
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482
Marshfield Clinic-Wausau Center Wausau Wisconsin 54401
Marshfield Medical Center - Weston Weston Wisconsin 54476
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids Wisconsin 54494
Cheyenne Regional Medical Center-West Cheyenne Wyoming 82001
Billings Clinic-Cody Cody Wyoming 82414
Welch Cancer Center Sheridan Wyoming 82801

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT03516279, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 2, 2026 · Synced May 10, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT03516279 live on ClinicalTrials.gov.

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