Independent directory Public ClinicalTrials.gov records United States
ClinicalTrials.gov record
Active, not recruiting Phase 2 Interventional

Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease

ClinicalTrials.gov ID: NCT03516279

Public ClinicalTrials.gov record NCT03516279. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 24, 2026, 7:33 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase II Study of Adding the Anti-PD-1 Pembrolizumab to Tyrosine Kinase Inhibitors in Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II trial studies how well pembrolizumab and dasatinib, imatinib mesylate, or nilotinib work in treating patients with chronic myeloid leukemia and persistent detection of minimal residual disease, defined as the levels of a gene product called bcr-abl in the blood. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of cancer cells to grow and spread. Dasatinib, imatinib mesylate, and nilotinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving pembrolizumab and dasatinib, imatinib mesylate, or nilotinib may work better in treating patients with chronic myeloid leukemia.

Study identification

NCT ID
NCT03516279
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 2
Enrollment
40 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 26, 2019 (Actual)
Primary completion
Aug 31, 2028 (Estimated)
Completion
Aug 31, 2031 (Estimated)
Last update posted
Sep 15, 2026

2019 – 2031

United States locations

U.S. sites
291
U.S. states
33
U.S. cities
212
Facility City State ZIP Site status
Fairbanks Memorial Hospital Fairbanks Alaska 99701 —
CTCA at Western Regional Medical Center Goodyear Arizona 85338 —
Cancer Center at Saint Joseph's Phoenix Arizona 85004 —
Mercy Hospital Fort Smith Fort Smith Arkansas 72903 —
CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas 71913 —
CARTI Cancer Center Little Rock Arkansas 72205 —
Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande California 93420 —
Mercy Cancer Center - Carmichael Carmichael California 95608 —
Mercy San Juan Medical Center Carmichael California 95608 —
Mercy Cancer Center - Elk Grove Elk Grove California 95758 —
Contra Costa Regional Medical Center Martinez California 94553-3156 —
Mercy Cancer Center Merced California 95340 —
Mercy Cancer Center - Rocklin Rocklin California 95765 —
Mercy Cancer Center - Sacramento Sacramento California 95816 —
Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California 93401 —
Mission Hope Medical Oncology - Santa Maria Santa Maria California 93444 —
BASS Medical Group - Lennon Walnut Creek California 94598 —
Woodland Memorial Hospital Woodland California 95695 —
Rocky Mountain Cancer Centers-Aurora Aurora Colorado 80012 —
Boulder Community Foothills Hospital Boulder Colorado 80303 —
Rocky Mountain Cancer Centers-Boulder Boulder Colorado 80304 —
Rocky Mountain Cancer Centers - Centennial Centennial Colorado 80112 —
Penrose-Saint Francis Healthcare Colorado Springs Colorado 80907 —
Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado 80907 —
Saint Francis Cancer Center Colorado Springs Colorado 80923 —
The Women's Imaging Center Denver Colorado 80209 —
Porter Adventist Hospital Denver Colorado 80210 —
Colorado Blood Cancer Institute Denver Colorado 80218 —
Presbyterian - Saint Lukes Medical Center - Health One Denver Colorado 80218 —
Rocky Mountain Cancer Centers-Midtown Denver Colorado 80218 —
Rocky Mountain Cancer Centers-Rose Denver Colorado 80220 —
Rose Medical Center Denver Colorado 80220 —
Mercy Medical Center Durango Colorado 81301 —
Southwest Oncology PC Durango Colorado 81301 —
Mountain Blue Cancer Care Center - Swedish Englewood Colorado 80113 —
Rocky Mountain Cancer Centers - Swedish Englewood Colorado 80113 —
Swedish Medical Center Englewood Colorado 80113 —
The Melanoma and Skin Cancer Institute Englewood Colorado 80113 —
Mountain Blue Cancer Care Center Golden Colorado 80401 —
Rocky Mountain Cancer Centers-Lakewood Lakewood Colorado 80228 —
Saint Anthony Hospital Lakewood Colorado 80228 —
Rocky Mountain Cancer Centers-Littleton Littleton Colorado 80120 —
Littleton Adventist Hospital Littleton Colorado 80122 —
Rocky Mountain Cancer Centers-Sky Ridge Lone Tree Colorado 80124 —
Longmont United Hospital Longmont Colorado 80501 —
Rocky Mountain Cancer Centers-Longmont Longmont Colorado 80501 —
Parker Adventist Hospital Parker Colorado 80138 —
Rocky Mountain Cancer Centers-Parker Parker Colorado 80138 —
Saint Mary Corwin Medical Center Pueblo Colorado 81004 —
Rocky Mountain Cancer Centers - Pueblo Pueblo Colorado 81008 —
Rocky Mountain Cancer Centers-Thornton Thornton Colorado 80260 —
Smilow Cancer Hospital-Derby Care Center Derby Connecticut 06418 —
Smilow Cancer Hospital Care Center-Fairfield Fairfield Connecticut 06824 —
Smilow Cancer Hospital Care Center at Glastonbury Glastonbury Connecticut 06033 —
Smilow Cancer Hospital Care Center - Guilford Guilford Connecticut 06437 —
Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut 06105 —
Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut 06510 —
Yale University New Haven Connecticut 06520 —
Yale-New Haven Hospital North Haven Medical Center North Haven Connecticut 06473 —
Smilow Cancer Hospital-Torrington Care Center Torrington Connecticut 06790 —
Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut 06611 —
Smilow Cancer Hospital-Waterbury Care Center Waterbury Connecticut 06708 —
Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut 06385 —
Beebe South Coastal Health Campus Frankford Delaware 19945 —
Beebe Medical Center Lewes Delaware 19958 —
Delaware Clinical and Laboratory Physicians PA Newark Delaware 19713 —
Helen F Graham Cancer Center Newark Delaware 19713 —
Medical Oncology Hematology Consultants PA Newark Delaware 19713 —
Christiana Care Health System-Christiana Hospital Newark Delaware 19718 —
Beebe Health Campus Rehoboth Beach Delaware 19971 —
TidalHealth Nanticoke / Allen Cancer Center Seaford Delaware 19973 —
Christiana Care Health System-Wilmington Hospital Wilmington Delaware 19801 —
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 —
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605 —
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 —
Walter Knox Memorial Hospital Emmett Idaho 83617 —
Idaho Urologic Institute-Meridian Meridian Idaho 83642 —
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 —
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 —
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864 —
Saint Anthony's Health Alton Illinois 62002 —
Rush - Copley Medical Center Aurora Illinois 60504 —
Illinois CancerCare-Bloomington Bloomington Illinois 61704 —
Illinois CancerCare-Canton Canton Illinois 61520 —
Memorial Hospital of Carbondale Carbondale Illinois 62902 —
SIH Cancer Institute Carterville Illinois 62918 —
Illinois CancerCare-Carthage Carthage Illinois 62321 —
Centralia Oncology Clinic Centralia Illinois 62801 —
Saint Mary's Hospital Centralia Illinois 62801 —
Northwestern University Chicago Illinois 60611 —
University of Illinois Chicago Illinois 60612 —
Carle at The Riverfront Danville Illinois 61832 —
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 —
Decatur Memorial Hospital Decatur Illinois 62526 —
Illinois CancerCare-Dixon Dixon Illinois 61021 —
Carle Physician Group-Effingham Effingham Illinois 62401 —
Crossroads Cancer Center Effingham Illinois 62401 —
Illinois CancerCare-Eureka Eureka Illinois 61530 —
Illinois CancerCare-Galesburg Galesburg Illinois 61401 —
Western Illinois Cancer Treatment Center Galesburg Illinois 61401 —
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 —
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045 —
Illinois CancerCare-Macomb Macomb Illinois 61455 —
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 —
Good Samaritan Regional Health Center Mount Vernon Illinois 62864 —
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 —
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 —
Illinois CancerCare-Pekin Pekin Illinois 61554 —
Illinois CancerCare-Peoria Peoria Illinois 61615 —
Methodist Medical Center of Illinois Peoria Illinois 61636 —
Illinois CancerCare-Peru Peru Illinois 61354 —
Valley Radiation Oncology Peru Illinois 61354 —
Illinois CancerCare-Princeton Princeton Illinois 61356 —
Southern Illinois University School of Medicine Springfield Illinois 62702 —
Springfield Clinic Springfield Illinois 62702 —
Memorial Medical Center Springfield Illinois 62781 —
Southwest Illinois Health Services LLP Swansea Illinois 62226 —
Carle Cancer Center Urbana Illinois 61801 —
The Carle Foundation Hospital Urbana Illinois 61801 —
Illinois CancerCare - Washington Washington Illinois 61571 —
Rush-Copley Healthcare Center Yorkville Illinois 60560 —
Mary Greeley Medical Center Ames Iowa 50010 —
McFarland Clinic - Ames Ames Iowa 50010 —
Mission Cancer and Blood - Ankeny Ankeny Iowa 50023 —
McFarland Clinic - Boone Boone Iowa 50036 —
Saint Anthony Regional Hospital Carroll Iowa 51401 —
Mercy Cancer Center-West Lakes Clive Iowa 50325 —
Mission Cancer and Blood - West Des Moines Clive Iowa 50325 —
Alegent Health Mercy Hospital Council Bluffs Iowa 51503 —
Greater Regional Medical Center Creston Iowa 50801 —
Iowa Methodist Medical Center Des Moines Iowa 50309 —
Mission Cancer and Blood - Des Moines Des Moines Iowa 50309 —
Broadlawns Medical Center Des Moines Iowa 50314 —
Mercy Medical Center - Des Moines Des Moines Iowa 50314 —
Mission Cancer and Blood - Laurel Des Moines Iowa 50314 —
Iowa Lutheran Hospital Des Moines Iowa 50316 —
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501 —
Trinity Regional Medical Center Fort Dodge Iowa 50501 —
McFarland Clinic - Jefferson Jefferson Iowa 50129 —
McFarland Clinic - Marshalltown Marshalltown Iowa 50158 —
Methodist West Hospital West Des Moines Iowa 50266-7700 —
Mercy Medical Center-West Lakes West Des Moines Iowa 50266 —
Central Care Cancer Center - Garden City Garden City Kansas 67846 —
Central Care Cancer Center - Great Bend Great Bend Kansas 67530 —
Lawrence Memorial Hospital Lawrence Kansas 66044 —
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas 67208 —
Ascension Via Christi Hospitals Wichita Wichita Kansas 67214 —
Cancer Center of Kansas - Wichita Wichita Kansas 67214 —
Wesley Medical Center Wichita Kansas 67214 —
Flaget Memorial Hospital Bardstown Kentucky 40004 —
Commonwealth Cancer Center-Corbin Corbin Kentucky 40701 —
Saint Joseph Hospital Lexington Kentucky 40504 —
Saint Joseph Radiation Oncology Resource Center Lexington Kentucky 40504 —
Saint Joseph Hospital East Lexington Kentucky 40509 —
Saint Joseph London London Kentucky 40741 —
Jewish Hospital Louisville Kentucky 40202 —
Saints Mary and Elizabeth Hospital Louisville Kentucky 40215 —
UofL Health Medical Center Northeast Louisville Kentucky 40245 —
Saint Joseph Mount Sterling Mount Sterling Kentucky 40353 —
Mercy Health - Paducah Medical Oncology and Hematology Paducah Kentucky 42003 —
Jewish Hospital Medical Center South Shepherdsville Kentucky 40165 —
Saint Agnes Hospital Baltimore Maryland 21229 —
Hickman Cancer Center Adrian Michigan 49221 —
Toledo Clinic Cancer Centers-Monroe Monroe Michigan 48162 —
Mayo Clinic in Rochester Rochester Minnesota 55905 —
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303 —
Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri 63011 —
Central Care Cancer Center - Bolivar Bolivar Missouri 65613 —
Parkland Health Center-Bonne Terre Bonne Terre Missouri 63628 —
Cox Cancer Center Branson Branson Missouri 65616 —
Saint Francis Medical Center Cape Girardeau Missouri 63703 —
Southeast Cancer Center Cape Girardeau Missouri 63703 —
Saint Luke's Hospital Chesterfield Missouri 63017 —
Parkland Health Center - Farmington Farmington Missouri 63640 —
MU Health Care Goldschmidt Cancer Center Jefferson City Missouri 65109 —
Freeman Health System Joplin Missouri 64804 —
Mercy Hospital Joplin Joplin Missouri 64804 —
Lake Regional Hospital Osage Beach Missouri 65065 —
Delbert Day Cancer Institute at PCRMC Rolla Missouri 65401 —
Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri 65401 —
Heartland Regional Medical Center Saint Joseph Missouri 64506 —
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670 —
Mercy Hospital Springfield Springfield Missouri 65804 —
CoxHealth South Hospital Springfield Missouri 65807 —
Saint Louis Cancer and Breast Institute-South City St Louis Missouri 63109 —
Mercy Hospital South St Louis Missouri 63128 —
Missouri Baptist Medical Center St Louis Missouri 63131 —
Mercy Hospital Saint Louis St Louis Missouri 63141 —
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080 —
BJC Outpatient Center at Sunset Hills Sunset Hills Missouri 63127 —
Mercy Hospital Washington Washington Missouri 63090 —
Community Hospital of Anaconda Anaconda Montana 59711 —
Billings Clinic Cancer Center Billings Montana 59101 —
Bozeman Health Deaconess Hospital Bozeman Montana 59715 —
Benefis Sletten Cancer Institute Great Falls Montana 59405 —
Great Falls Clinic Great Falls Montana 59405 —
Saint Peter's Community Hospital Helena Montana 59601 —
Kalispell Regional Medical Center Kalispell Montana 59901 —
Community Medical Center Missoula Montana 59804 —
Nebraska Medicine-Bellevue Bellevue Nebraska 68123 —
Nebraska Cancer Specialists/Oncology Hematology West PC Grand Island Nebraska 68803 —
Heartland Hematology and Oncology Kearney Nebraska 68845 —
CHI Health Good Samaritan Kearney Nebraska 68847 —
Saint Elizabeth Regional Medical Center Lincoln Nebraska 68510 —
Nebraska Medicine-Village Pointe Omaha Nebraska 68118 —
Alegent Health Immanuel Medical Center Omaha Nebraska 68122 —
Hematology and Oncology Consultants PC Omaha Nebraska 68122 —
Alegent Health Bergan Mercy Medical Center Omaha Nebraska 68124 —
Alegent Health Lakeside Hospital Omaha Nebraska 68130 —
Creighton University Medical Center Omaha Nebraska 68131 —
University of Nebraska Medical Center Omaha Nebraska 68198 —
Midlands Community Hospital Papillion Nebraska 68046 —
Morristown Medical Center Morristown New Jersey 07960 —
Overlook Hospital Summit New Jersey 07902 —
Garnet Health Medical Center Middletown New York 10940 —
Southeastern Medical Oncology Center-Clinton Clinton North Carolina 28328 —
Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina 27534 —
Wayne Memorial Hospital Goldsboro North Carolina 27534 —
Onslow Memorial Hospital Jacksonville North Carolina 28546 —
Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina 28546 —
Good Samaritan Hospital - Cincinnati Cincinnati Ohio 45220 —
Bethesda North Hospital Cincinnati Ohio 45242 —
TriHealth Cancer Institute-Westside Cincinnati Ohio 45247 —
TriHealth Cancer Institute-Anderson Cincinnati Ohio 45255 —
MetroHealth Medical Center Cleveland Ohio 44109 —
Toledo Clinic Cancer Centers-Maumee Maumee Ohio 43537 —
Mercy Health Perrysburg Cancer Center Perrysburg Ohio 43551 —
Mercy Health - Saint Anne Hospital Toledo Ohio 43623 —
Toledo Clinic Cancer Centers-Toledo Toledo Ohio 43623 —
Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma 73505 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Mercy Hospital Oklahoma City Oklahoma City Oklahoma 73120 —
Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma 74146 —
Saint Alphonsus Cancer Care Center-Baker City Baker City Oregon 97814 —
Saint Alphonsus Cancer Care Center-Ontario Ontario Oregon 97914 —
Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania 19317 —
Geisinger Medical Center Danville Pennsylvania 17822 —
Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania 18201 —
Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania 17837 —
Lewistown Hospital Lewistown Pennsylvania 17044 —
Geisinger Cancer Services-Pottsville Pottsville Pennsylvania 17901 —
Community Medical Center Scranton Pennsylvania 18510 —
Geisinger Medical Oncology-Selinsgrove Selinsgrove Pennsylvania 17870 —
Geisinger Medical Group State College Pennsylvania 16801 —
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711 —
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316 —
Prisma Health Cancer Institute - Laurens Clinton South Carolina 29325 —
Prisma Health Cancer Institute - Easley Easley South Carolina 29640 —
BI-LO Charities Children's Cancer Center Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605 —
Prisma Health Greenville Memorial Hospital Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615 —
Prisma Health Cancer Institute - Greer Greer South Carolina 29650 —
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672 —
Memorial Hospital Chattanooga Tennessee 37404 —
Vanderbilt-Ingram Cancer Center Cool Springs Franklin Tennessee 37067 —
Pulmonary Medicine Center of Chattanooga-Hixson Hixson Tennessee 37343 —
Vanderbilt Breast Center at One Hundred Oaks Nashville Tennessee 37204 —
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232 —
Memorial GYN Plus Ooltewah Tennessee 37363 —
Saint Joseph Regional Cancer Center Bryan Texas 77802 —
Sovah Health Martinsville Martinsville Virginia 24112 —
Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington 98310 —
Highline Medical Center-Main Campus Burien Washington 98166 —
Saint Elizabeth Hospital Enumclaw Washington 98022 —
Saint Francis Hospital Federal Way Washington 98003 —
Saint Clare Hospital Lakewood Washington 98499 —
Jefferson Healthcare Port Townsend Washington 98368 —
Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo Washington 98370 —
Saint Michael Cancer Center Silverdale Washington 98383 —
Franciscan Research Center-Northwest Medical Plaza Tacoma Washington 98405 —
Northwest Medical Specialties PLLC Tacoma Washington 98405 —
West Virginia University Healthcare Morgantown West Virginia 26506 —
ThedaCare Regional Cancer Center Appleton Wisconsin 54911 —
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701 —
Mayo Clinic Health System-Eau Claire Clinic Eau Claire Wisconsin 54701 —
Mayo Clinic Health System Eau Claire Hospital-Luther Campus Eau Claire Wisconsin 54703 —
Marshfield Medical Center - Ladysmith Ladysmith Wisconsin 54848 —
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 —
Medical College of Wisconsin Milwaukee Wisconsin 53226 —
Marshfield Clinic-Minocqua Center Minocqua Wisconsin 54548 —
Froedtert and MCW Moorland Reserve Health Center New Berlin Wisconsin 53151 —
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 —
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 —
Marshfield Clinic-Wausau Center Wausau Wisconsin 54401 —
Marshfield Medical Center - Weston Weston Wisconsin 54476 —
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids Wisconsin 54494 —
Cheyenne Regional Medical Center-West Cheyenne Wyoming 82001 —
Billings Clinic-Cody Cody Wyoming 82414 —
Welch Cancer Center Sheridan Wyoming 82801 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT03516279, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 15, 2026 · Synced Oct 24, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT03516279 live on ClinicalTrials.gov.

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