ClinicalTrials.gov record
An Induction Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 1)
ClinicalTrials.gov ID: NCT03518086
Public ClinicalTrials.gov record NCT03518086. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Induction Study of Mirikizumab in Conventional-Failed and Biologic-Failed Patients With Moderately to Severely Active Ulcerative Colitis (LUCENT 1)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety and efficacy of Mirikizumab in participants with moderately to severely active ulcerative colitis (UC) who have had an inadequate response to, loss of response, or intolerant to conventional or biologic therapy for UC.
Study identification
- NCT ID
- NCT03518086
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,281 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 18, 2018 (Actual)
- Primary completion
- Jan 21, 2021 (Actual)
- Completion
- May 15, 2024 (Actual)
- Last update posted
- May 31, 2025
2018 – 2024
United States locations
- U.S. sites
- 98
- U.S. states
- 32
- U.S. cities
- 86
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Digestive Health Specialists of the Southeast | Dothan | Alabama | 36305 | — |
| Dcr-Pi, Pc | Litchfield Park | Arizona | 85340 | — |
| Maricopa Integrated Health System | Phoenix | Arizona | 85008 | — |
| Physicians Research Group | Tempe | Arizona | 85284 | — |
| Yuma Gastro LLC | Yuma | Arizona | 85364 | — |
| Valley Gastroenterology | Arcadia | California | 91006 | — |
| Care Access Research | Berkeley | California | 94705 | — |
| Citrus Valley Health Partners | Covina | California | 91722 | — |
| Valley View Internal Medicine | Garden Grove | California | 92843 | — |
| Om Research, LLC | Lancaster | California | 93534 | — |
| Catalina Research Institute, LLC | Montclair | California | 91763 | — |
| California Medical Research Associates | Northridge | California | 91324 | — |
| Gastroenterology Associates | Pasadena | California | 91105 | — |
| Clinical Applications Laboratories, Inc. | San Diego | California | 92103 | — |
| UCSF Medical Center at Mission Bay | San Francisco | California | 94158 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Delta Waves Sleep Disorders and Research Center | Colorado Springs | Colorado | 80918 | — |
| Gastroenterology Consultants of Clearwater | Clearwater | Florida | 33756 | — |
| West Central Gastroenterology d/b/a Gastro Florida | Clearwater | Florida | 33761 | — |
| Clinical Research of West Florida, Inc. (Clearwater) | Clearwater | Florida | 33765 | — |
| Pioneer Clinical Research | Coral Springs | Florida | 33067 | — |
| Direct Helpers Medical Center | Hialeah | Florida | 33012 | — |
| The Center for Gastrointestinal Disorders | Hollywood | Florida | 33021 | — |
| Nature Coast Clinical Research, LLC | Inverness | Florida | 34452 | — |
| SIH Research, LLC | Kissimmee | Florida | 34741 | — |
| Columbus Clinical Services, LLC | Miami | Florida | 33125 | — |
| Research Associates of South Florida, LLC | Miami | Florida | 33134 | — |
| IMIC, Inc. | Miami | Florida | 33176 | — |
| Inpatient Research Clinic, LLC | Miami Lakes | Florida | 33014 | — |
| Life Medical Center & Research, Inc | Miami Lakes | Florida | 33014 | — |
| Wellness Clinical Research | Miami Lakes | Florida | 33016 | — |
| Pharma Research International, Inc. | Naples | Florida | 34110 | — |
| Center for Interventional Endoscopy | Orlando | Florida | 32803 | — |
| Clintheory Healthcare | Orlando | Florida | 32818 | — |
| Gastroenterology Associates of Pensacola, PA | Pensacola | Florida | 32503 | — |
| Florida Digestive Specialist | St. Petersburg | Florida | 33709 | — |
| Florida Medical Clinic LLC | Zephyrhills | Florida | 33542-7505 | — |
| Digestive Healthcare of Georgia | Atlanta | Georgia | 30309 | — |
| Gastrointestinal Diseases Research | Columbus | Georgia | 31904 | — |
| Atlanta Gastroenterology Specialists, PC | Suwanee | Georgia | 30024 | — |
| Grand Teton Research Group | Idaho Falls | Idaho | 83404 | — |
| NorthShore University HealthSystem | Evanston | Illinois | 60201 | — |
| Indiana University School of Medicine | Indianapolis | Indiana | 46202 | — |
| Iowa Digestive Disease Center | Clive | Iowa | 50325 | — |
| Cotton-O'Neil Clinical Research Center, Digestive Health | Topeka | Kansas | 66606 | — |
| Texas Digestive Disease Consultants | Baton Rouge | Louisiana | 70809 | — |
| Clinical Trials of SWLA, LLC | Lake Charles | Louisiana | 70601 | — |
| Delta Research Partners LLC | Monroe | Louisiana | 71201 | — |
| Tulane Univ School of Med | New Orleans | Louisiana | 70112 2715 | — |
| Nola Research Works, LLC | New Orleans | Louisiana | 70125 | — |
| Clinical Research Institute of Michigan, LLC | Chesterfield | Michigan | 48047 | — |
| Henry Ford Health System | Novi | Michigan | 48377 | — |
| Gastroenterology Associates of Western Michigan, P.L.C. | Wyoming | Michigan | 49519 | — |
| Huron Gastroenterology Associates | Ypsilanti | Michigan | 48197 | — |
| MNGI Digestive Health - Plymouth Endoscopy Center & Clinic | Plymouth | Minnesota | 55446 | — |
| Care Access Research LLC | Jackson | Mississippi | 39206 | — |
| Digestive Health Specialists | Tupelo | Mississippi | 38801 | — |
| Washington University Medical School | St Louis | Missouri | 63110 | — |
| Capital Health Medical Center Hopewell | Pennington | New Jersey | 08534 | — |
| Northwell Health | Great Neck | New York | 11021 | — |
| NYU Langone Long Island Clinical Research Associates | Lake Success | New York | 11042 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | — |
| Carolina Digestive Diseases and Endoscopy Center | Greenville | North Carolina | 27834 | — |
| Wake Forest University School of Medicine | Winston-Salem | North Carolina | 27157-1045 | — |
| Trinity Health Center Medical Arts | Minot | North Dakota | 58701 | — |
| META Medical Research Institute, LLC | Dayton | Ohio | 45432 | — |
| Paramount Medical Research | Middleburg Heights | Ohio | 44130 | — |
| Care Access Research - Youngstown | Poland | Ohio | 44514 | — |
| Great Lakes Medical Research, LLC | Westlake | Ohio | 44145 | — |
| Central Sooner Research | Norman | Oklahoma | 73071 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Digestive Disease Associates | Wyomissing | Pennsylvania | 19610 | — |
| Ocean State Clinical Research Partners | Lincoln | Rhode Island | 02865 | — |
| Invocare Clinical Research Center | Mauldin | South Carolina | 29662 | — |
| Invocare Clinical Research Center | West Columbia | South Carolina | 29169 | — |
| Midwest Medical Care | Sioux Falls | South Dakota | 57108 | — |
| Gastro One | Germantown | Tennessee | 38138 | — |
| Galen Medical Group | Hixson | Tennessee | 37343 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| University of Texas Medical Branch at Galveston | Galveston | Texas | 77555 | — |
| Digestive Health Associates of Texas | Garland | Texas | 75044 | — |
| Houston Methodist Research Ins | Houston | Texas | 77030 | — |
| Biopharma Informatic, Inc. | Houston | Texas | 77043 | — |
| Gastroenterology Research of San Antonio | San Antonio | Texas | 78229 | — |
| Southern Star Research Institute, LLC | San Antonio | Texas | 78229 | — |
| Bandera Family Health Care | San Antonio | Texas | 78249 | — |
| Texas Digestive Disease Consultants | Southlake | Texas | 76092 | — |
| GI and Liver Research, LLC | Webster | Texas | 77598 | — |
| Care Access Research LLC - Salt Lake City | Ogden | Utah | 84403 | — |
| Care Access Research LLC - Salt Lake City | Salt Lake City | Utah | 84124 | — |
| Emeritas Research Group | Leesburg | Virginia | 20176 | — |
| Blue Ridge Medical Research | Lynchburg | Virginia | 24502 | — |
| The Gastroenterology Group, P.C. | Reston | Virginia | 20191 | — |
| Carilion Clinic | Roanoke | Virginia | 24016 | — |
| University of Washington Medical Center | Seattle | Washington | 98195-6424 | — |
| Wisconsin Center for Advanced Research | Milwaukee | Wisconsin | 53215 | — |
| Allegiance Research Specialists, LLC | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 404 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03518086, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 31, 2025 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03518086 live on ClinicalTrials.gov.