Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer
Public ClinicalTrials.gov record NCT03539536. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2, Open-Label Safety and Efficacy Study of Telisotuzumab Vedotin (ABBV-399) in Subjects With Previously Treated c-Met+ Non-Small Cell Lung Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is designed to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that overexpress c-Met (c-Met+) best suited for telisotuzumab vedotin therapy in the second line or third line setting (Stage 1) and then to expand the group(s) to further evaluate efficacy in the selected population(s) (Stage 2). After the Stage 2 global enrollment is completed, an additional cohort at an alternate dose level will evaluate the safety and efficacy of telisotuzumab vedotin (Stage 3).
Study identification
- NCT ID
- NCT03539536
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 270 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 10, 2018 (Actual)
- Primary completion
- Jul 2026 (Estimated)
- Completion
- Aug 2026 (Estimated)
- Last update posted
- Nov 5, 2025
2018 – 2026
United States locations
- U.S. sites
- 56
- U.S. states
- 30
- U.S. cities
- 52
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of South Alabama /ID# 212939 | Mobile | Alabama | 36604-3302 | — |
| Mayo Clinic Arizona /ID# 218550 | Phoenix | Arizona | 85054-4504 | — |
| Highlands Oncology Group, PA /ID# 215600 | Springdale | Arkansas | 72762 | — |
| University of California, Los Angeles /ID# 203219 | Los Angeles | California | 90095 | — |
| LA Hematology-Oncology Med Group /ID# 203338 | Orange | California | 92868 | — |
| Sutter Medical Center Sacramen /ID# 203299 | Sacramento | California | 95816 | — |
| Icri /Id# 227835 | Whittier | California | 90603 | — |
| Univ of Colorado Cancer Center /ID# 203212 | Aurora | Colorado | 80045 | — |
| Duplicate_Rocky Mountain Cancer Centers - Lone Tree /ID# 215789 | Lone Tree | Colorado | 80124 | — |
| Advanced Cancer Treatment Center /ID# 239565 | Brooksville | Florida | 34613-6072 | — |
| AdventHealth Celebration /ID# 215649 | Celebration | Florida | 34747-4970 | — |
| Duplicate_Mayo Clinic /ID# 218488 | Jacksonville | Florida | 32224 | — |
| Duplicate_AdventHealth Cancer Institute - Orlando /ID# 239960 | Orlando | Florida | 32804 | — |
| Straub Clinic and Hospital /ID# 217905 | Honolulu | Hawaii | 96813-3097 | — |
| Northwestern University Feinberg School of Medicine /ID# 203239 | Chicago | Illinois | 60611-2927 | — |
| The University of Chicago Medical Center /ID# 203216 | Chicago | Illinois | 60637-1443 | — |
| Duplicate_NorthShore University HealthSystem /ID# 215583 | Evanston | Illinois | 60201 | — |
| Ingalls Memorial Hosp /ID# 203228 | Harvey | Illinois | 60426 | — |
| Joliet Oncology-Hematology Associates, LTD /ID# 203238 | Joliet | Illinois | 60435 | — |
| Goshen Center for Cancer Care /ID# 215584 | Goshen | Indiana | 46526 | — |
| Univ Kansas Med Ctr /ID# 216804 | Kansas City | Kansas | 66160 | — |
| Cancer Center of Kansas /ID# 203235 | Wichita | Kansas | 67214 | — |
| Duplicate_Baptist Health /ID# 203283 | Lexington | Kentucky | 40503-1463 | — |
| Duplicate_Norton Cancer Institute - St Matthews /ID# 203284 | Louisville | Kentucky | 40207 | — |
| Central Maine Medical Center /ID# 216583 | Lewiston | Maine | 04240 | — |
| Massachusetts General Hospital /ID# 203215 | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center /ID# 208124 | Boston | Massachusetts | 02215-5400 | — |
| Dana-Farber Cancer Institute /ID# 203248 | Boston | Massachusetts | 02215 | — |
| Henry Ford Hospital /ID# 203220 | Detroit | Michigan | 48202 | — |
| Mayo Clinic - Rochester /ID# 215603 | Rochester | Minnesota | 55905-0001 | — |
| Hattiesburg Clinic /ID# 227691 | Hattiesburg | Mississippi | 39401 | — |
| St. Lukes Cancer Institute /ID# 227697 | Kansas City | Missouri | 64111-5905 | — |
| Washington University-School of Medicine /ID# 203217 | St Louis | Missouri | 63110 | — |
| Duplicate_Intermountain Health - St Vincent Regional Hospital - Cancer Centers o /ID# 203292 | Billings | Montana | 59102 | — |
| Duplicate_Dartmouth-Hitchcock Medical Center - 1 Medical Center Drive /ID# 203350 | Lebanon | New Hampshire | 03756 | — |
| Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 228868 | East Brunswick | New Jersey | 08816 | — |
| Atlantic Health System /ID# 203404 | Morristown | New Jersey | 07960-6136 | — |
| Capital Health Medical Center /ID# 203403 | Pennington | New Jersey | 08534-2520 | — |
| Overlook Medical Center /ID# 211160 | Summit | New Jersey | 07901-3533 | — |
| University of New Mexico /ID# 208339 | Albuquerque | New Mexico | 87102-4517 | — |
| Duplicate_Gabrail Cancer Center Research /ID# 216056 | Canton | Ohio | 44718 | — |
| Univ Hosp Cleveland /ID# 215648 | Cleveland | Ohio | 44106 | — |
| Mercy Cancer Center /ID# 231972 | Elyria | Ohio | 44024 | — |
| Mercy Research Mercy Clinic Oklahoma Communities, Inc. / OKC /ID# 230154 | Oklahoma City | Oklahoma | 73120 | — |
| Providence Cancer Center Oncology and Hematology Care - Westside Portland /ID# 203301 | Portland | Oregon | 97225 | — |
| Penn State University and Milton S. Hershey Medical Center /ID# 221844 | Hershey | Pennsylvania | 17033-2360 | — |
| Duplicate_Allegheny General Hospital /ID# 215585 | Pittsburgh | Pennsylvania | 15212 | — |
| Veterans Healthcare System /ID# 215602 | Pittsburgh | Pennsylvania | 15240 | — |
| Thompson Cancer Survival Ctr /ID# 228874 | Knoxville | Tennessee | 37916 | — |
| Vanderbilt Ingram Cancer Center /ID# 203281 | Nashville | Tennessee | 37232-0021 | — |
| Houston Methodist Hospital /ID# 213268 | Houston | Texas | 77030 | — |
| Baylor Scott & White Medical Center- Temple /ID# 216578 | Temple | Texas | 76508-0001 | — |
| Virginia Cancer Specialists - Fairfax /ID# 203224 | Fairfax | Virginia | 22031 | — |
| Valley Medical Center /ID# 231459 | Renton | Washington | 98055-5738 | — |
| University of Washington /ID# 206056 | Seattle | Washington | 98109 | — |
| Wisconsin Medical Center /ID# 210062 | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 196 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03539536, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 5, 2025 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03539536 live on ClinicalTrials.gov.