A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety
Public ClinicalTrials.gov record NCT03541174. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Multi-center, Blinded, Randomized, Parallel-group, Phase 3 Study With Aprocitentan in Subjects With Resistant Hypertension (RHT)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this clinical trial is to show the blood pressure lowering effect of aprocitentan, a new drug, when added to other anti-hypertensive drugs of patients with difficult to control (resistant) high blood pressure (hypertension), and to show that blood pressure reduction is kept for long period of time.
Study identification
- NCT ID
- NCT03541174
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 730 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 18, 2018 (Actual)
- Primary completion
- May 14, 2021 (Actual)
- Completion
- Apr 25, 2022 (Actual)
- Last update posted
- Mar 21, 2023
2018 – 2022
United States locations
- U.S. sites
- 41
- U.S. states
- 20
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Advanced Cardiovascular, LLC | Alexander City | Alabama | 35010 | — |
| Chrishard Medical Group | Inglewood | California | 90301 | — |
| Clinical Trials Research | Lincoln | California | 95648 | — |
| Academic Medical Research Institute Inc | Los Angeles | California | 90022 | — |
| Amicis Research Center | Northridge | California | 91324 | — |
| California Kidney Specialists | San Dimas | California | 91773 | — |
| Bay Area Cardiology Associates, P.A. | Brandon | Florida | 33511 | — |
| Century Clinical Research, Inc | Daytona Beach | Florida | 32117 | — |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32224 | — |
| Canvas Clinical Research, LLC | Lake Worth | Florida | 33467 | — |
| East Coast Institute for Research | Saint Augustine | Florida | 32086 | — |
| Premier Medical Associates | The Villages | Florida | 32159 | — |
| SIU School of Medicine Center for Clinical Research | Springfield | Illinois | 62702 | — |
| Midwest Institute for Clinical Research | Indianapolis | Indiana | 46260 | — |
| Cardiovascular Research of Northwest Indiana, L.L.C. | Munster | Indiana | 46231 | — |
| Reid Physician Associates | Richmond | Indiana | 47374 | — |
| Grace Research, LLC | Bossier City | Louisiana | 71111 | — |
| MedStar Health Research Institute | Hyattsville | Maryland | 20782 | — |
| Clinical Research Consultants, LLC | Kansas City | Missouri | 64111 | — |
| Hypertension and Nephrology Association PA | Eatontown | New Jersey | 07724 | — |
| Renal Medicine Associates | Albuquerque | New Mexico | 87109 | — |
| Albany Medical College | Albany | New York | 12206 | — |
| Scott Research Inc | Laurelton | New York | 11413 | — |
| Great Lakes Medical Research LLC | Westfield | New York | 14787 | — |
| Metrolina Internal Medicine/Internal Medicine Research | Charlotte | North Carolina | 28207 | — |
| East Carolina University | Greenville | North Carolina | 27834 | — |
| Physician's East Endocrinology | Greenville | North Carolina | 27834 | — |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | — |
| University Hospitals Cleveland Medical Center - Neurological Institute | Cleveland | Ohio | 44106 | — |
| Willamette Valley Clinical Studies | Eugene | Oregon | 97404 | — |
| TLM Medical Services LLC | Columbia | South Carolina | 29204 | — |
| DeGarmo Institute of Medical Research | Greer | South Carolina | 29650 | — |
| Stern Cardiovascular Foundation, Inc | Germantown | Tennessee | 38138 | — |
| LifeDOC Research PLLC | Memphis | Tennessee | 38119 | — |
| Amarillo Heart Clinical Research Institute, Inc. | Amarillo | Texas | 79106 | — |
| LinQ Research, LLC | Pearland | Texas | 77584 | — |
| Mercury Clinical Research | Webster | Texas | 77598 | — |
| St. George Kidney Care LLC dba Southern Utah Kidney and Hypertension Center | St. George | Utah | 84790 | — |
| Burke Internal Medicine & Research | Burke | Virginia | 22015 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| Milwaukee Nephrologists, SC | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 118 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03541174, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 21, 2023 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03541174 live on ClinicalTrials.gov.