Patient-reported Outcomes in Vericiguat-treated Patients With HFpEF
Public ClinicalTrials.gov record NCT03547583. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Parallel-group, Placebo-controlled, Double-blind, Multi-center Trial to Evaluate the Efficacy and Safety of the Oral sGC stImulator Vericiguat to Improve Physical Functioning in Activities of Daily Living in Patients With Heart Failure and Preserved Ejection Fraction (VITALITY-HFpEF)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary hypothesis in this trial is that the treatment with vericiguat 10 mg or 15 mg in patients with HFpEF improves the KCCQ PLS (Kansas City Cardiomyopathy Questionnaire Physical limitation score) compared to placebo after 24 weeks of treatment.
Study identification
- NCT ID
- NCT03547583
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 789 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 45 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 14, 2018
- Primary completion
- Oct 14, 2019
- Completion
- Nov 3, 2019
- Last update posted
- Jan 5, 2021
2018 – 2019
United States locations
- U.S. sites
- 29
- U.S. states
- 20
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| WestSide Medical | Beverly Hills | California | 90211 | — |
| Capitol Interventional Cardiology | Carmichael | California | 95608 | — |
| Interventional Cardiology Medical Group | West Hills | California | 91307 | — |
| Penrose-St. Francis Health Services | Colorado Springs | Colorado | 80923 | — |
| Cardiology Associates of Fairfield County, PC | Trumbull | Connecticut | 06611 | — |
| Cardiology Associates Of South Florida PA | Boynton Beach | Florida | 33472 | — |
| Cardiovascular and Vein Center of Florida | Bradenton | Florida | 34209 | — |
| Cardiology Associates Research Company | Daytona Beach | Florida | 32117 | — |
| LifeSpring Research Foundation, LLC | Miami | Florida | 33130 | — |
| Southwest Florida Research | Naples | Florida | 34102 | — |
| East Coast Institute for Research, LLC | Saint Augustine | Florida | 32086 | — |
| Cardiology Partners | Wellington | Florida | 33449 | — |
| Fox Valley Clinical Research Center, LLC | Aurora | Illinois | 60506 | — |
| Advocate Condell Medical Center | Libertyville | Illinois | 60048 | — |
| Reid Health | Richmond | Indiana | 47374 | — |
| Research Integrity, LLC | Owensboro | Kentucky | 42303 | — |
| Heart Clinic of Hammond | Hammond | Louisiana | 70403 | — |
| Anne Arundel Health System | Annapolis | Maryland | 21401 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Riser Medical Associates | Picayune | Mississippi | 39466 | — |
| St. Louis Heart & Vascular, PC | St Louis | Missouri | 63136 | — |
| Glacier View Research Institute | Kalispell | Montana | 59901 | — |
| Bryan Heart | Lincoln | Nebraska | 68506 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | — |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | — |
| Carolina Heart Specialists | Lancaster | South Carolina | 29720 | — |
| Stern Cardiovascular Center | Germantown | Tennessee | 38138 | — |
| Clinical Advancement Center, PLLC | San Antonio | Texas | 78212-4740 | — |
| Corporation Lane Research Center | Virginia Beach | Virginia | 23462 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 148 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03547583, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 5, 2021 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03547583 live on ClinicalTrials.gov.