ClinicalTrials.gov record
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
ClinicalTrials.gov ID: NCT03550391
Public ClinicalTrials.gov record NCT03550391. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 22, 2026, 8:25 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Trial of Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
Study identification
- NCT ID
- NCT03550391
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Canadian Cancer Trials Group
- Network
- Enrollment
- 206 participants
Conditions and interventions
Conditions
Interventions
- Hippocampal-avoidant (HA-WBRT) Radiotherapy Radiation
- Memantine Drug
- Stereotactic Radiosurgery (SRS) Procedure
Radiation · Drug · Procedure
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 21, 2018
- Primary completion
- Jun 29, 2027
- Completion
- Dec 30, 2027
- Last update posted
- Apr 13, 2026
2018 – 2027
United States locations
- U.S. sites
- 73
- U.S. states
- 26
- U.S. cities
- 66
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arizona Cancer Center-Orange Grove Campus | Tucson | Arizona | 85704 | Recruiting |
| University of Arizona Cancer Center-North Campus | Tucson | Arizona | 85719 | Recruiting |
| City of Hope Corona | Corona | California | 92882 | Recruiting |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | Recruiting |
| City of Hope at Irvine Lennar | Irvine | California | 92618 | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | Suspended |
| City of Hope Antelope Valley | Lancaster | California | 93534 | Recruiting |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | Active, not recruiting |
| Kaiser Permanente-Rancho Cordova Cancer Center | Rancho Cordova | California | 95670 | Active, not recruiting |
| Rohnert Park Cancer Center | Rohnert Park | California | 94928 | Active, not recruiting |
| The Permanente Medical Group-Roseville Radiation Oncology | Roseville | California | 95678 | Active, not recruiting |
| South Sacramento Cancer Center | Sacramento | California | 95823 | Active, not recruiting |
| Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | 95051 | Active, not recruiting |
| City of Hope South Pasadena | South Pasadena | California | 91030 | Recruiting |
| Kaiser Permanente Cancer Treatment Center | South San Francisco | California | 94080 | Active, not recruiting |
| City of Hope South Bay | Torrance | California | 90503 | Recruiting |
| City of Hope Upland | Upland | California | 91786 | Recruiting |
| Boca Raton Regional Hospital | Boca Raton | Florida | 33486 | Active, not recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | 33146 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | Recruiting |
| Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida | 33021 | Active, not recruiting |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224-9980 | Active, not recruiting |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | Recruiting |
| Memorial Hospital West | Pembroke Pines | Florida | 33028 | Active, not recruiting |
| UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | 33324 | Recruiting |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Active, not recruiting |
| Piedmont Hospital | Atlanta | Georgia | 30309 | Active, not recruiting |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | Suspended |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | Suspended |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | Suspended |
| Northwestern University | Chicago | Illinois | 60611 | Active, not recruiting |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | Recruiting |
| Loyola University Medical Center | Maywood | Illinois | 60153 | Suspended |
| HSHS Saint Elizabeth's Hospital | O'Fallon | Illinois | 62269 | Recruiting |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | Recruiting |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | Recruiting |
| Carle Cancer Center | Urbana | Illinois | 61801 | Recruiting |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | Active, not recruiting |
| Community Cancer Center North | Indianapolis | Indiana | 46256 | Active, not recruiting |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | Recruiting |
| Luminis Health Anne Arundel Medical Center | Annapolis | Maryland | 21401 | Active, not recruiting |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889-5600 | Recruiting |
| Tufts Medical Center | Boston | Massachusetts | 02111 | Recruiting |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | Recruiting |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | Active, not recruiting |
| Regions Hospital | Saint Paul | Minnesota | 55101 | Suspended |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | Recruiting |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | 63376 | Recruiting |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | 63141 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Siteman Cancer Center-South County | St Louis | Missouri | 63129 | Recruiting |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | Recruiting |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | Suspended |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | Recruiting |
| Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center | Lebanon | New Hampshire | 03756 | Active, not recruiting |
| AtlantiCare Surgery Center | Egg Harbor | New Jersey | 08234 | Recruiting |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | Recruiting |
| SUNY Upstate Medical Center-Community Campus | Syracuse | New York | 13215 | Suspended |
| Mission Hospital | Asheville | North Carolina | 28801 | Active, not recruiting |
| Cone Health Cancer Center | Greensboro | North Carolina | 27403 | Recruiting |
| East Carolina University | Greenville | North Carolina | 27834 | Active, not recruiting |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | Recruiting |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | Recruiting |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | Active, not recruiting |
| Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | 97210 | Recruiting |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | Recruiting |
| Fox Chase Cancer Center Buckingham | Furlong | Pennsylvania | 18925 | Active, not recruiting |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | Active, not recruiting |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | Recruiting |
| Self Regional Healthcare | Greenwood | South Carolina | 29646 | Active, not recruiting |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | Suspended |
| Dartmouth Cancer Center - North | Saint Johnsbury | Vermont | 05819 | Active, not recruiting |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 13 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03550391, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 13, 2026 · Synced Apr 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03550391 live on ClinicalTrials.gov.