A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer
Public ClinicalTrials.gov record NCT03561220. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is a large, prospective, pragmatic, controlled comparison of patient-centric outcomes \[quality of life (QOL), toxicity, and disease control\] between parallel cohorts of men with prostate cancer treated simultaneously at proton therapy facilities and at geographically similar conventional (photon-based) radiation facilities using intensity-modulated radiation therapy (IMRT) techniques.
Study identification
- NCT ID
- NCT03561220
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 3,000 participants
Conditions and interventions
Conditions
Interventions
- Standard of Care IMRT (Photon) Radiation
- Standard of Care Proton Therapy Radiation
- Proton Arm 1: Standard Proton Therapy Radiation
- Proton Arm 2: Hypofractionated Proton Therapy Radiation
Radiation
Eligibility (public fields only)
- Age range
- 30 Years to 85 Years
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 5, 2018 (Actual)
- Primary completion
- Feb 15, 2026 (Actual)
- Completion
- Jul 1, 2027 (Estimated)
- Last update posted
- Mar 9, 2026
2018 – 2027
United States locations
- U.S. sites
- 53
- U.S. states
- 26
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham (UAB) | Birmingham | Alabama | 35294 | — |
| University of California San Diego | La Jolla | California | 92093 | — |
| Proton Therapy Treatment Center - Loma Linda University | Loma Linda | California | 92354 | — |
| Sutter Health | Roseville | California | 95661 | — |
| California Protons Cancer Therapy Center | San Diego | California | 92121 | — |
| Department of Radiation Oncology Davis Cancer Pavilion | Gainesville | Florida | 32611 | — |
| University of Florida Proton Therapy Institute | Jacksonville | Florida | 32206 | — |
| Ackerman Cancer Center | Jacksonville | Florida | 32223 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| University of Miami School of Medicine | Miami | Florida | 33136 | — |
| Miami Cancer Institute | Miami | Florida | 33176 | — |
| Orlando Health UF Health Center | Orlando | Florida | 32806 | — |
| Winship Cancer Institute - Emory University | Atlanta | Georgia | 30322 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Northwestern Medicine Proton Center | Warrenville | Illinois | 60555 | — |
| University of Kansas Medical Center | Lawrence | Kansas | 66045 | — |
| University of Louisville | Louisville | Kentucky | 40292 | — |
| Willis-Knighton Medical Center PTC | Shreveport | Louisiana | 71103 | — |
| Johns Hopkins University | Baltimore | Maryland | 21218 | — |
| University of Maryland | College Park | Maryland | 20742 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Mayo Clinic Health System | Mankato | Minnesota | 56001 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| S Lee Kling Proton Therapy Center - Washington University Medical Center | St Louis | Missouri | 63110 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08901 | — |
| Covenant Health | Somerset | New Jersey | 08873 | — |
| New York Proton Center | New York | New York | 10035 | — |
| Weill Cornell | New York | New York | 10065 | — |
| The Duke University Health System | Durham | North Carolina | 27705 | — |
| UNC- Rex Hospital | Raleigh | North Carolina | 27607 | — |
| University of Cincinnati Medical PTC | Cincinnati | Ohio | 45267 | — |
| Cleveland Clinic | Cleveland | Ohio | 44106 | — |
| University Hospitals- Seidman Cancer Center | Cleveland | Ohio | 44106 | — |
| Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | — |
| Oregon Health & Science University | Portland | Oregon | 97201 | — |
| University of Pennsylvania--Penn Medicine | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19144 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29407 | — |
| Covenant Health Proton Center | Knoxville | Tennessee | 37909 | — |
| Texas Oncology | Austin | Texas | 78731 | — |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Texas Center for Proton Therapy | Irving | Texas | 75063 | — |
| Texas Oncology - Longview | Longview | Texas | 75601 | — |
| Texas Oncology - McKinney | McKinney | Texas | 75071 | — |
| Texas Oncology - Plano West | Plano | Texas | 75093 | — |
| Texas Oncology - Waco | Waco | Texas | 76712 | — |
| University of Virginia | Charlottesville | Virginia | 22904 | — |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Hampton University Proton Therapy Institute | Hampton | Virginia | 23666 | — |
| Seattle Care Alliance/University of Washington | Seattle | Washington | 98133 | — |
| Mayo Clinic Health System | Eau Claire | Wisconsin | 54703 | — |
| Mayo Clinic Health System-Franciscan Healthcare | Sparta | Wisconsin | 54656 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03561220, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 9, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03561220 live on ClinicalTrials.gov.