GRAVITAS-309: Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
Public ClinicalTrials.gov record NCT03584516. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
GRAVITAS-309: A Phase 2/3 Study of Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess the efficacy and safety of itacitinib in combination with corticosteroids as first-line treatment for moderate or severe chronic graft-versus-host disease (cGVHD).
Study identification
- NCT ID
- NCT03584516
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 155 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 17, 2019 (Actual)
- Primary completion
- Nov 3, 2023 (Actual)
- Completion
- Nov 3, 2023 (Actual)
- Last update posted
- Oct 20, 2025
2019 – 2023
United States locations
- U.S. sites
- 39
- U.S. states
- 23
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arizona Cancer Center - Out Pt. | Tucson | Arizona | 85724 | — |
| University of Arkansas For Medical Sciences - Winthrop P Rockefeller Cancer Institute | Little Rock | Arkansas | 72205 | — |
| City of Hope National Medical Center | Duarte | California | 91010 | — |
| University of California San Diego Medical Center, Moores Cancer Center | La Jolla | California | 92093 | — |
| University of Miami Sylvester Comprehensive Cancer Center | Miami | Florida | 33136-1002 | — |
| Winship Cancer Institute of Emory University | Atlanta | Georgia | 30322 | — |
| Augusta University - Medical College of Georgia | Augusta | Georgia | 30912 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Illinois Cancer Specialists | Chicago | Illinois | 60714 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153-3328 | — |
| Advocate Lutheran General Hospital - Oncology Specislists Sc | Park Ridge | Illinois | 60028 | — |
| Indiana University Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202-5201 | — |
| University of Kansas Hospital Authority | Westwood | Kansas | 66160 | — |
| Tulane University | New Orleans | Louisiana | 70112-2618 | — |
| University of Maryland - Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111-1552 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Spectrum Health | Grand Rapids | Michigan | 49503 | — |
| University of Minnesota, Masonic Cancer Center | Minneapolis | Minnesota | 55455 | — |
| Saint Louis University Cancer Center | St Louis | Missouri | 63110 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601-8550 | — |
| University of Rochester, James P. Wilmot Cancer Center | Rochester | New York | 14642-0001 | — |
| Stony Brook University Medical Center | Stony Brook | New York | 11794 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Oncology Hematology Care, Inc | Cincinnati | Ohio | 45236 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106-1716 | — |
| University of Pennsylvania Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| Jefferson University Hospitals | Philadelphia | Pennsylvania | 19107 | — |
| Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15232-1309 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105-2108 | — |
| Tri Star Bone Marrow Transplant | Nashville | Tennessee | 37203 | — |
| Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| St David'S South Austin Medical Center | Austin | Texas | 78704 | — |
| Texas Oncology - Medical City Dallas | Dallas | Texas | 75230 | — |
| Texas Oncology - Baylor Sammons Cancer Center | Dallas | Texas | 75246 | — |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 94 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03584516, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 20, 2025 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03584516 live on ClinicalTrials.gov.