A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee

ClinicalTrials.gov ID: NCT03588975

Public ClinicalTrials.gov record NCT03588975. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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Official title

A Prospective, Open-label, Randomized, Concurrent Active-controlled, Longitudinal, Multicenter, Phase 3 Clinical Study of the Safety and Efficacy of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The objective of this study is to compare the efficacy and safety of MACI® vs arthroscopic microfracture in the treatment of participants aged 10 to 17 years with symptomatic articular chondral or osteochondral defects of the knee.

Study identification

NCT ID: NCT03588975
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Vericel Corporation; Industry
Enrollment: 45 participants

Conditions and interventions

Conditions

Interventions

MACI Biological
microfracture Procedure

Biological · Procedure

Eligibility (public fields only)

Age range: 10 Years to 17 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 24, 2018 (Actual)
Primary completion: Feb 2030 (Estimated)
Completion: Feb 2030 (Estimated)
Last update posted: Oct 13, 2026

2018 – 2030

United States locations

U.S. sites: 14
U.S. states: 9
U.S. cities: 12

Facility	City	State	ZIP	Site status
Stanford University School of Medicine	Palo Alto	California	94304	Recruiting
Shriners Hospital for Children Northern California	Sacramento	California	95817	Recruiting
University of California Davis Lawrence J. Ellison Ambulatory Care Center Orthopaedic Surgery	Sacramento	California	95817	Recruiting
Ochsner Health System-Elmwood	New Orleans	Louisiana	70121	Recruiting
Johns Hopkins Hospital	Baltimore	Maryland	21224	Recruiting
University of Michigan Medsport Orthopaedic Surgery	Ann Arbor	Michigan	48106	Recruiting
Montefiore Medical Center/Albert Einstein College of Medicine	The Bronx	New York	10467	Completed
Akron Children's Hospital	Akron	Ohio	44308	Recruiting
The Ohio State University Jameson Crane Sports Medicine Institute	Columbus	Ohio	43202	Recruiting
Penn Medicine University City	Philadelphia	Pennsylvania	19104	Recruiting
The Children's Hospital of Philadelphia - The Hub for Clinical Collaboration	Philadelphia	Pennsylvania	19104	Recruiting
Texas' Children Hospital	Houston	Texas	77094	Completed
Children's Medical Center Plano	Plano	Texas	75024	Completed
Children's Hospital of Wisconsin	Milwaukee	Wisconsin	53201	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03588975, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 13, 2026 · Synced Oct 21, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT03588975 live on ClinicalTrials.gov.

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