EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin)
Public ClinicalTrials.gov record NCT03594110. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicentre International Randomized Parallel Group Double-blind Placebo-controlled Clinical Trial of EMPAgliflozin Once Daily to Assess Cardio-renal Outcomes in Patients With Chronic KIDNEY Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary aim of the study is to investigate the effect of empagliflozin on kidney disease progression or cardiovascular death versus placebo on top of standard of care in patients with pre-existing chronic kidney disease. After completion of the interventional part of the study (primary study completion) a subset of participants will be followed up in a post-trial observational (non-interventional) manner for cardio-renal outcomes (estimated study completion date).
Study identification
- NCT ID
- NCT03594110
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 6,609 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 31, 2019 (Actual)
- Primary completion
- Jul 5, 2022 (Actual)
- Completion
- Jul 2, 2024 (Actual)
- Last update posted
- Jul 20, 2025
2019 – 2024
United States locations
- U.S. sites
- 47
- U.S. states
- 25
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Nephrology Consultants, LLC | Huntsville | Alabama | 35805 | — |
| Aventiv Research, Inc | Mesa | Arizona | 85210 | — |
| Southern California Permanente Medical Group | San Diego | California | 92123 | — |
| University of California Los Angeles | Sylmar | California | 91342 | — |
| University of California Los Angeles | Torrance | California | 90502 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06510 | — |
| Chase Medical Research, LLC | Thomaston | Connecticut | 06787 | — |
| Midland Florida Clinical Reearch Center, LLC | DeLand | Florida | 32720 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| East Coast Institute for Research, LLC | Jacksonville | Florida | 32216 | — |
| East Coast Clinical Research, Inc | Lake City | Florida | 32055 | — |
| Total Research Group, LLC | Miami | Florida | 33126 | — |
| Hanson Clinical Research Center, Inc. | Port Charlotte | Florida | 33952 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| The Jones Center for Diabetes and Endocrine Wellness | Macon | Georgia | 31210 | — |
| Cedar Crosse Research Center | Chicago | Illinois | 60607 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Saint Elizabeth Healthcare | Covington | Kentucky | 41011 | — |
| Lexington VA Health Care System - Troy Bowling Campus | Lexington | Kentucky | 40502 | — |
| Medstar Health Research Institute | Baltimore | Maryland | 21239 | — |
| Kidney Care and Transplant Services of New England, PC | West Springfield | Massachusetts | 01089 | — |
| Saint Clair Specialty Physicians | Roseville | Michigan | 48066 | — |
| Clinical Research Consultants, LLC | Kansas City | Missouri | 64111 | — |
| VA Southern Nevada Healthcare System | North Las Vegas | Nevada | 89086 | — |
| Seacoast Kidney and Hypertension Specialists | Portsmouth | New Hampshire | 03801 | — |
| SUNY Downstate Medical Center | Brooklyn | New York | 11203 | — |
| Mountain Kidney and Hypertension Associates, PA | Asheville | North Carolina | 28801 | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | — |
| Brookview Hills Research Associates LLC | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| University Hospitals of Cleveland | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19114 | — |
| Carolina Diabetes & Kidney Center | Sumter | South Carolina | 29150 | — |
| Regional Health Clinical Research | Rapid City | South Dakota | 57701 | — |
| Research Institute of Dallas | Dallas | Texas | 75231 | — |
| Renal Disease Research Institute | Dallas | Texas | 75246 | — |
| Academy Of Diabetes, Thyroid And Endocrine, PA | El Paso | Texas | 79935 | — |
| Pioneer Research Solutions, Inc. | Houston | Texas | 77099 | — |
| P&I Clinical Research, LLC | Lufkin | Texas | 75904 | — |
| Texas Institute for Kidney and Endocrine Disorders | Lufkin | Texas | 75904 | — |
| Clinical Advancement Center PLLC | San Antonio | Texas | 78212 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| University of Utah Health Sciences Center | Salt Lake City | Utah | 84108 | — |
| Salem VA Medical Center | Salem | Virginia | 24153 | — |
| Providence Medical Research Center | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 193 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03594110, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 20, 2025 · Synced Oct 27, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03594110 live on ClinicalTrials.gov.