A Study to Evaluate the Safety and Efficacy of CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus
Public ClinicalTrials.gov record NCT03617536. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Safety and Efficacy of Oral CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of 3 dose levels of oral CR845 compared to placebo in reducing the intensity of itch in chronic kidney disease (CKD) patients with moderate-to-severe pruritus. This study will consist of a Screening Period, a 7-day Run-in Period, a 12 week Treatment Period, and a Follow-up Visit (approximately 7 days after the last dose of study drug).
Study identification
- NCT ID
- NCT03617536
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 269 participants
Conditions and interventions
Conditions
Interventions
- CR845 0.25 mg Oral Tablet Drug
- CR845 0.5 mg Oral Tablet Drug
- CR845 1 mg Oral Tablet Drug
- Placebo Oral Tablet Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 5, 2018 (Actual)
- Primary completion
- Oct 24, 2019 (Actual)
- Completion
- Nov 14, 2019 (Actual)
- Last update posted
- Jan 24, 2024
2018 – 2019
United States locations
- U.S. sites
- 60
- U.S. states
- 24
- U.S. cities
- 55
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cara Therapeutics Study Site | Birmingham | Alabama | 35233 | — |
| Cara Therapeutics Study Site | Florence | Alabama | 35630 | — |
| Cara Therapeutics Study Site | Phoenix | Arizona | 85016 | — |
| Cara Therapeutics Study Site | Prescott | Arizona | 86401 | — |
| Cara Therapeutics Study Site | Sun City | Arizona | 85351 | — |
| Cara Therapeutics Study Site | Harrisburg | Arkansas | 72432 | — |
| Cara Therapeutics Study Site | Bakersfield | California | 93309 | — |
| Cara Therapeutics Study Site 2 | Bakersfield | California | 99309 | — |
| Cara Therapeutics Study Site | Canyon Country | California | 91351 | — |
| Cara Therapeutics Study Site | Escondido | California | 92025 | — |
| Cara Therapeutics Study Site | Lomita | California | 90717 | — |
| Cara Therapeutics Study Site | Northridge | California | 91324 | — |
| Cara Therapeutics Study Site | Riverside | California | 92505 | — |
| Cara Therapeutics Study Site | Sacramento | California | 95831 | — |
| Cara Therapeutics Study Site | Whittier | California | 90602 | — |
| Cara Therapeutics Study Site | Denver | Colorado | 80230 | — |
| Cara Therapeutics Study Site | Washington D.C. | District of Columbia | 20037 | — |
| Cara Therapeutics Study Site | Edgewater | Florida | 32132 | — |
| Cara Therapeutics Study Site | Hialeah | Florida | 33016 | — |
| Cara Therapeutics Study Site | Hollywood | Florida | 33024 | — |
| Cara Therapeutics Study Site | Lake Worth | Florida | 33467 | — |
| Cara Therapeutics Study Site 1 | Miami | Florida | 33125 | — |
| Cara Therapeutics Study Site 2 | Miami | Florida | 33155 | — |
| Cara Therapeutics Study Site | Ocala | Florida | 34471 | — |
| Cara Therapeutics Study Site | Orlando | Florida | 32810 | — |
| Cara Therapeutics Study Site | Tampa | Florida | 33614 | — |
| Cara Therapeutics Study Site | Temple Terrace | Florida | 33637 | — |
| Cara Therapeutics Study Site | Augusta | Georgia | 30909 | — |
| Cara Therapeutics Study Site | Sandy Springs | Georgia | 30328 | — |
| Cara Therapeutics Study Site | Crystal Lake | Illinois | 60012 | — |
| Cara Therapeutics Study Site | Evanston | Illinois | 60201 | — |
| Cara Therapeutics Study Site | Iowa City | Iowa | 52242 | — |
| Cara Therapeutics Study Site | Metairie | Louisiana | 70006 | — |
| Cara Therapeutics Study Site | New Orleans | Louisiana | 70115 | — |
| Cara Therapeutics Study Site | Zachary | Louisiana | 70791 | — |
| Cara Therapeutics Study Site | Baltimore | Maryland | 21287 | — |
| Cara Therapeutics Study Site | Takoma Park | Maryland | 20912 | — |
| Cara Therapeutics Study Site | Flint | Michigan | 48503 | — |
| Cara Therapeutics Study Site 2 | Flint | Michigan | 48532 | — |
| Cara Therapeutics Study Site | Roseville | Michigan | 48066 | — |
| Cara Therapeutics Study Site | Saint Clair | Michigan | 48081 | — |
| Cara Therapeutics Study Site | Kansas City | Missouri | 64111 | — |
| Cara Therapeutics Study Site | Brooklyn | New York | 11229 | — |
| Cara Therapeutics Study Site | Mineola | New York | 11501 | — |
| Cara Therapeutics Study Site | Rocky Mount | North Carolina | 27804 | — |
| Cara Therapeutics Study Site | Columbus | Ohio | 43215 | — |
| Cara Therapeutics Study Site | Norman | Oklahoma | 73071 | — |
| Cara Therapeutics Study Site | Camp Hill | Pennsylvania | 17011 | — |
| Cara Therapeutics Study Site | Providence | Rhode Island | 02903 | — |
| Cara Therapeutics Study Site | Warwick | Rhode Island | 02886 | — |
| Cara Therapeutics Study Site | Greenville | South Carolina | 29605 | — |
| Cara Therapeutics Study Site | Rapid City | South Dakota | 57702 | — |
| Cara Therapeutics Study Site | Corsicana | Texas | 75110 | — |
| Cara Therapeutics Study Site | Gonzales | Texas | 78629 | — |
| Cara Therapeutics Study Site | Houston | Texas | 77074 | — |
| Cara Therapeutics Study Site | Houston | Texas | 77081 | — |
| Cara Therapeutics Study Site | Plano | Texas | 75093 | — |
| Cara Therapeutics Study Site | San Antonio | Texas | 78207 | — |
| Cara Therapeutics Study Site | San Antonio | Texas | 78224 | — |
| Cara Therapeutics Study Site | Alexandria | Virginia | 22304 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03617536, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 24, 2024 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03617536 live on ClinicalTrials.gov.