A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (YOSEMITE)
Public ClinicalTrials.gov record NCT03622580. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Patients With Diabetic Macular Edema (YOSEMITE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy, safety, and pharmacokinetics of faricimab administered at 8-week intervals or as specified in the protocol following treatment initiation, compared with aflibercept once every 8 weeks (Q8W), in participants with diabetic macular edema (DME).
Study identification
- NCT ID
- NCT03622580
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 940 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 5, 2018 (Actual)
- Primary completion
- Oct 20, 2020 (Actual)
- Completion
- Sep 3, 2021 (Actual)
- Last update posted
- Jul 11, 2025
2018 – 2021
United States locations
- U.S. sites
- 85
- U.S. states
- 33
- U.S. cities
- 81
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barnet Dulaney Perkins Eye Center | Mesa | Arizona | 85206 | — |
| Arizona Retina and Vitreous Consultants | Phoenix | Arizona | 85021 | — |
| Retina Associates Southwest PC | Tucson | Arizona | 85704 | — |
| Retinal Diagnostic Center | Campbell | California | 95008 | — |
| Eye Medical Center | Fresno | California | 93720 | — |
| East Bay Retina Consultants | Oakland | California | 94609 | — |
| Southern CA Desert Retina Cons | Palm Desert | California | 92211 | — |
| California Eye Specialists Medical group Inc. | Pasadena | California | 91107 | — |
| Retina Consultants, San Diego | Poway | California | 92064 | — |
| Retina Consultants of Southern California | Redlands | California | 92373 | — |
| Kaiser Permanente Riverside Medical Center | Riverside | California | 92505 | — |
| University of California, Davis, Eye Center | Sacramento | California | 95817 | — |
| W Coast Retina Med Group Inc | San Francisco | California | 94107 | — |
| Orange County Retina Med Group | Santa Ana | California | 92705 | — |
| Colorado Retina Associates, PC | Lakewood | Colorado | 80228 | — |
| Rand Eye | Deerfield Beach | Florida | 33064 | — |
| Retina Care Specialists | Palm Beach Gardens | Florida | 33410 | — |
| Retina Specialty Institute | Pensacola | Florida | 32503 | — |
| Southern Vitreoretinal Assoc | Tallahassee | Florida | 32308 | — |
| Retina Associates of Florida, LLC | Tampa | Florida | 33609 | — |
| University of South Florida | Tampa | Florida | 33612 | — |
| Georgia Retina PC | Marietta | Georgia | 30060 | — |
| Retina Consultants of Hawaii | ‘Aiea | Hawaii | 96701 | — |
| Midwest Eye Institute | Indianapolis | Indiana | 46290 | — |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266 | — |
| Retina Associates | Lenexa | Kansas | 66215 | — |
| Vitreo-Retinal Consultants | Wichita | Kansas | 67214 | — |
| Retina Associates of Kentucky | Lexington | Kentucky | 40509 | — |
| Paducah Retinal Center | Paducah | Kentucky | 42001 | — |
| Maine Eye Center | Portland | Maine | 04101 | — |
| The Retina Care Center | Baltimore | Maryland | 21209 | — |
| Johns Hopkins Med; Wilmer Eye Inst | Baltimore | Maryland | 21287 | — |
| Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Cumberland Valley Retina PC | Hagerstown | Maryland | 21740 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Beetham Eye Institute, Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| Vitreo-Retinal Associates, PC | Worcester | Massachusetts | 01605 | — |
| Foundation for Vision Research | Grand Rapids | Michigan | 49546 | — |
| Assoc Retinal Consultants PC | Royal Oak | Michigan | 48073 | — |
| Associated Retinal Consultants, P.C. | Traverse City | Michigan | 49686 | — |
| Vitreoretinal Surgery | Edina | Minnesota | 55435 | — |
| Midwest Vision Research Foundation | Chesterfield | Missouri | 63017 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Mid Atlantic Retina - Wills Eye Hospital | Cherry Hill | New Jersey | 08034 | — |
| NJ Retina | Edison | New Jersey | 08820 | — |
| Retinal & Ophthalmic Cons PC | Northfield | New Jersey | 08225 | — |
| Retina Associates of NJ | Teaneck | New Jersey | 07666 | — |
| University of New Mexico | Albuquerque | New Mexico | 87131 | — |
| Capital Region Retina | Albany | New York | 12206 | — |
| Long Is. Vitreoretinal Consult | Great Neck | New York | 11021 | — |
| Retina Vit Surgeons/Central NY | Liverpool | New York | 13088 | — |
| MaculaCare, PLLC | New York | New York | 10021 | — |
| Island Retina | Shirley | New York | 11967 | — |
| Western Carolina Retinal Associate PA | Asheville | North Carolina | 28803 | — |
| Char Eye Ear &Throat Assoc | Charlotte | North Carolina | 28210 | — |
| Graystone Eye | Hickory | North Carolina | 28602 | — |
| Carolina Eye Associates | Southern Pines | North Carolina | 28387 | — |
| Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| Cincinnati Eye Institute | Cincinnati | Ohio | 45242 | — |
| Retina Assoc of Cleveland Inc | Cleveland | Ohio | 44122 | — |
| OSU Eye Physicians & Surgeons | Columbus | Ohio | 43212 | — |
| Midwest Retina | Dublin | Ohio | 43016 | — |
| Retina Vitreous Center | Edmond | Oklahoma | 73013 | — |
| Retina Northwest | Portland | Oregon | 97221 | — |
| Black Hills Eye Institute | Rapid City | South Dakota | 57701 | — |
| Charles Retina Institute | Memphis | Tennessee | 38119 | — |
| Retina Res Institute of Texas | Abilene | Texas | 79606 | — |
| Austin Clinical Research LLC | Austin | Texas | 78750 | — |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| Retina Specialists | DeSoto | Texas | 75115 | — |
| Valley Retina Institute P.A. | Harlingen | Texas | 78550 | — |
| Retina & Vitreous of Texas | Houston | Texas | 77025 | — |
| Med Center Ophthalmology Assoc | San Antonio | Texas | 78240 | — |
| Eye Care Assoc of East Texas | Tyler | Texas | 75701 | — |
| Strategic Clinical Research Group, LLC | Willow Park | Texas | 76087 | — |
| Retina Associates of Utah | Salt Lake City | Utah | 84107 | — |
| University of Utah; Division of Gastroenterology/Hepatology | Salt Lake City | Utah | 84132 | — |
| University of Vermont Medical Center; Investigational Drug Service, Pharmacy Department/Baird 1 | Burlington | Vermont | 05401 | — |
| Emerson Clinical Research Institute | Falls Church | Virginia | 22042 | — |
| Piedmont Eye Center | Lynchburg | Virginia | 24502 | — |
| Wagner Macula & Retina Center | Norfolk | Virginia | 23502 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204 | — |
| West Virginia University Eye Institute | Morgantown | West Virginia | 26506 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 100 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03622580, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 11, 2025 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03622580 live on ClinicalTrials.gov.