A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients
Public ClinicalTrials.gov record NCT03626688. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Ralinepag When Added to PAH Standard of Care or PAH Specific Background Therapy in Subjects With WHO Group 1 PAH
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.
Study identification
- NCT ID
- NCT03626688
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 687 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 24, 2019 (Actual)
- Primary completion
- Dec 31, 2025 (Actual)
- Completion
- Dec 31, 2025 (Actual)
- Last update posted
- Jun 16, 2026
2019 – 2025
United States locations
- U.S. sites
- 68
- U.S. states
- 29
- U.S. cities
- 53
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| St. Joseph's Hospital and Medical Center | Phoenix | Arizona | 85013 | — |
| University of Arizona | Tucson | Arizona | 85724 | — |
| UCSD Health Sciences | La Jolla | California | 92037 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90024 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Keck Hospital of USC | Los Angeles | California | 90033 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| VA Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| University of California, Irvine | Orange | California | 19103 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| SBPA Research LLC | Santa Barbara | California | 93105 | — |
| Stanford Healthcare | Stanford | California | 94305 | — |
| LA Biomedical Research Institute Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| National Jewish Health | Denver | Colorado | 80206 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Central Florida Pulmonary Group | Orlando | Florida | 32803 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| Piedmont Healthcare Pulmonary and Critical Care Research | Austell | Georgia | 30106 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Ascension Alexian Brothers | Elk Grove Village | Illinois | 60007 | — |
| Indiana University School of Medicine | Indianapolis | Indiana | 46202 | — |
| Community Health Network Cancer Center North | Indianapolis | Indiana | 46250 | — |
| St. Vincent Medical Group, Inc. | Indianapolis | Indiana | 46260 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| Kentuckiana Pulmonary Research Center | Louisville | Kentucky | 40202 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | — |
| Chest Medicine Associates | South Portland | Maine | 04106 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Boston University Medical Center | Boston | Massachusetts | 02118 | — |
| Spectrum Health Medical Group | Grand Rapids | Michigan | 49546 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| University of New Mexico | Albuquerque | New Mexico | 87131 | — |
| Winthrop Hospital | Mineola | New York | 11501 | — |
| NYU Langone Medical Center | New York | New York | 10016 | — |
| Weill-Cornell-New York Presbyterian Hospital | New York | New York | 10021 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| East Carolina University | Greenville | North Carolina | 27834 | — |
| University of Cincinnati-Medical Science Building | Cincinnati | Ohio | 45267 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Integris Baptist Medical Center | Oklahoma City | Oklahoma | 73112 | — |
| Oregon Clinic-Pulmonary West | Portland | Oregon | 97225 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Temple University | Philadelphia | Pennsylvania | 19140 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Statcare Pulmonary Consultants | Knoxville | Tennessee | 37919 | — |
| Ascension Texas Cardiovascular | Austin | Texas | 78705 | — |
| Baylor University Medical Center | Dallas | Texas | 75246 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Memorial Hermann Hospital | Houston | Texas | 77030 | — |
| The Methodist Hospital Research Institute | Houston | Texas | 77030 | — |
| Vermont Lung Center | Colchester | Vermont | 05446 | — |
| University of Virginia Medical Center | Charlottesville | Virginia | 22908 | — |
| Sentara Cardiovascular Research Institute | Norfolk | Virginia | 23507 | — |
| Carilion Clinic Pulmonary and Sleep Medicine | Roanoke | Virginia | 24014 | — |
| Medical College of Wisconsin/Froedtert Hospital | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 141 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03626688, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 16, 2026 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03626688 live on ClinicalTrials.gov.