A Study of NKTR-214 Combined With Nivolumab vs Nivolumab Alone in Participants With Previously Untreated Inoperable or Metastatic Melanoma
Public ClinicalTrials.gov record NCT03635983. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Open-label Study of NKTR-214 Combined With Nivolumab Versus Nivolumab in Participants With Previously Untreated Unresectable or Metastatic Melanoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to test the effectiveness (how well the drug works), safety, and tolerability of the investigational drug called NKTR-214, when combined with nivolumab versus nivolumab given alone in participants with previously untreated melanoma skin cancer that is either unable to be surgically removed or has spread
Study identification
- NCT ID
- NCT03635983
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 783 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 21, 2018 (Actual)
- Primary completion
- Nov 19, 2021 (Actual)
- Completion
- Mar 19, 2024 (Actual)
- Last update posted
- Apr 1, 2025
2018 – 2024
United States locations
- U.S. sites
- 24
- U.S. states
- 18
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0187 | Tucson | Arizona | 85724 | — |
| Local Institution - 0014 | La Jolla | California | 92093 | — |
| Local Institution - 0122 | Stanford | California | 94305 | — |
| Local Institution - 0051 | Aurora | Colorado | 80045 | — |
| Local Institution - 0065 | New Haven | Connecticut | 06510 | — |
| Local Institution - 0153 | Miami | Florida | 33136 | — |
| Local Institution - 0017 | Miami Beach | Florida | 33140 | — |
| Local Institution - 0112 | Tampa | Florida | 33612 | — |
| Local Institution - 0012 | Atlanta | Georgia | 30322-1013 | — |
| Local Institution - 0019 | Louisville | Kentucky | 40202 | — |
| Local Institution - 0018 | Boston | Massachusetts | 02215 | — |
| Local Institution - 0188 | Ann Arbor | Michigan | 48109 | — |
| Local Institution - 0186 | Fridley | Minnesota | 55432 | — |
| Local Institution - 0135 | St Louis | Missouri | 63110 | — |
| Local Institution - 0016 | Hackensack | New Jersey | 07601 | — |
| Local Institution - 0185 | New Brunswick | New Jersey | 08903 | — |
| Local Institution - 0141 | New York | New York | 10065 | — |
| Local Institution - 0037 | Cleveland | Ohio | 44195 | — |
| Local Institution - 0011 | Portland | Oregon | 97213 | — |
| Local Institution - 0013 | Portland | Oregon | 97239 | — |
| St. Luke's Hospital & Health Network | Easton | Pennsylvania | 18045 | — |
| Local Institution - 0015 | Philadelphia | Pennsylvania | 19111 | — |
| Local Institution - 0001 | Houston | Texas | 77030 | — |
| Local Institution - 0064 | Fairfax | Virginia | 22031 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 143 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03635983, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 1, 2025 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03635983 live on ClinicalTrials.gov.