Tocilizumab in Cardiac Transplantation
Public ClinicalTrials.gov record NCT03644667. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Targeting Inflammation and Alloimmunity in Heart Transplant Recipients With Tocilizumab (RTB-004)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this research study is to see if a study drug called Tocilizumab will, when given with standard anti-rejection medicines, lead to better heart transplantation outcomes at 1 year after the transplant. Specifically, the investigators will evaluate whether taking tocilizumab leads to less rejection, less development of unwanted antibodies, and better heart function.
Study identification
- NCT ID
- NCT03644667
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 385 participants
Conditions and interventions
Conditions
Interventions
- tocilizumab Biological
- Placebo Biological
- Standard of Care Triple IS Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 20, 2018 (Actual)
- Primary completion
- Mar 25, 2025 (Actual)
- Completion
- Mar 25, 2025 (Actual)
- Last update posted
- Sep 29, 2026
2018 – 2025
United States locations
- U.S. sites
- 20
- U.S. states
- 13
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cedars Sinai Medical Center (CACS) | Beverly Hills | California | 90211 | — |
| University of California, San Diego: Sulpizio Cardiovascular Center (CASD) | La Jolla | California | 92037 | — |
| Stanford Health Care (CASU) | Stanford | California | 94305 | — |
| Tampa General Hospital (FLTG) | Tampa | Florida | 33606 | — |
| Northwestern Memorial Hospital (INLM) | Chicago | Illinois | 60611 | — |
| Tufts Medical Center (MANM) | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital (MAMG) | Boston | Massachusetts | 02114 | — |
| St. Luke's Hospital of Kansas City (MOLH) | Kansas City | Missouri | 64111 | — |
| University of Nebraska Medical Center (NEUN) | Omaha | Nebraska | 68198 | — |
| Mount Sinai Medical Center (NYMS) | New York | New York | 10029 | — |
| Columbia University Medical Center (NYCP) | New York | New York | 10032 | — |
| Montefiore Medical Center (NYMA) | The Bronx | New York | 10467 | — |
| Duke University Medical Center (NCDU) | Durham | North Carolina | 27710 | — |
| Cleveland Clinic Foundation (OHCC) | Cleveland | Ohio | 44195 | — |
| Penn State Health: Milton S. Hershey Medical Center (PAHE) | Hershey | Pennsylvania | 17033 | — |
| Hospital of the University of Pennsylvania (PAUP) | Philadelphia | Pennsylvania | 19104 | — |
| Allegheny General Hospital (PAAG) | Pittsburgh | Pennsylvania | 15212 | — |
| Vanderbilt University Medical Center (TNVU) | Nashville | Tennessee | 37232 | — |
| Baylor University Medical Center (TXTX) | Dallas | Texas | 75246 | — |
| University of Utah (UTMC) | Salt Lake City | Utah | 84132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03644667, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 29, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03644667 live on ClinicalTrials.gov.