Study of APVO436 in Patients With AML or MDS

ClinicalTrials.gov ID: NCT03647800

Public ClinicalTrials.gov record NCT03647800. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jun 26, 2026, 8:01 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase 1B Open-Label, Dose-Escalation and Dose-Expansion Study of APVO436 in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) or High-Grade Myelodysplastic Syndrome (MDS)

Study identification

NCT ID: NCT03647800
Recruitment status: Not listed
Study type: Interventional
Phase: Phase 1
Lead sponsor: Aptevo Research and Development LLC; Industry
Enrollment: 136 participants

Conditions and interventions

Conditions

Interventions

APVO436 Biological

Biological

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 12, 2018
Primary completion: Dec 14, 2022
Completion: Jun 14, 2023
Last update posted: Feb 9, 2022

2018 – 2023

United States locations

U.S. sites: 12
U.S. states: 10
U.S. cities: 12

Facility	City	State	ZIP	Site status
University of California, San Francisco Medical Center	San Francisco	California	94143	Active, not recruiting
Colorado Blood Cancer Institute	Denver	Colorado	80218	Recruiting
University of Florida College of Medicine	Gainesville	Florida	32610	Recruiting
Sylvester Comprehensive Cancer Center/UMHC	Miami	Florida	33136	Recruiting
The University of Kansas Clinical Research Center	Westwood	Kansas	66205	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Active, not recruiting
The Ohio State University Wexner Medical Center/James Cancer Hospital	Columbus	Ohio	43210	Recruiting
Greenville Health System, Institute for Translational Oncology Research	Greenville	South Carolina	29605	Recruiting
University of Texas Southwestern Medical Center	Dallas	Texas	75390	Recruiting
The University of Texas M.D. Anderson Cancer Center	Houston	Texas	77030	Recruiting
University of Utah, Huntsman Cancer Institute	Salt Lake City	Utah	84112	Recruiting
Fred Hutchinson Cancer Research Center	Seattle	Washington	98109	Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03647800, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 9, 2022 · Synced Jun 26, 2026

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The complete protocol, eligibility criteria, and contact information for NCT03647800 live on ClinicalTrials.gov.

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