National Adaptive Trial for PTSD Related Insomnia
Public ClinicalTrials.gov record NCT03668041. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
CSP #2016 - National Adaptive Trial for PTSD Related Insomnia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Many Veterans with posttraumatic stress disorder (PTSD) have trouble sleeping or have frequent nightmares. So far, no medication has been approved for treatment of insomnia in PTSD. The purpose of this research study is to find out if taking medications called trazodone or eszopiclone can help decrease symptoms of insomnia in patients with PTSD. PTSD is a form of intense anxiety which sometimes results from severe trauma. Symptoms may include nightmares, flashbacks, troublesome memories, difficulty sleeping, poor concentration, irritability, anger, and emotional withdrawal. Insomnia is a disorder that can make it hard to fall sleep, stay asleep or cause a person to wake up too early and not be able to fall back to sleep.
Study identification
- NCT ID
- NCT03668041
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 673 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 24, 2021
- Primary completion
- Mar 29, 2026
- Completion
- Mar 29, 2026
- Last update posted
- Jun 2, 2026
2021 – 2026
United States locations
- U.S. sites
- 35
- U.S. states
- 22
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Birmingham VA Medical Center, Birmingham, AL | Birmingham | Alabama | 35233 | — |
| Tuscaloosa VA Medical Center, Tuscaloosa, AL | Tuscaloosa | Alabama | 35404 | — |
| Phoenix VA Health Care System, Phoenix, AZ | Phoenix | Arizona | 85012 | — |
| VA Loma Linda Healthcare System, Loma Linda, CA | Loma Linda | California | 92357-1000 | — |
| VA Long Beach Healthcare System, Long Beach, CA | Long Beach | California | 90822 | — |
| VA Palo Alto Health Care System, Palo Alto, CA | Palo Alto | California | 94304-1207 | — |
| VA San Diego Healthcare System, San Diego, CA | San Diego | California | 92161 | — |
| San Francisco VA Medical Center, San Francisco, CA | San Francisco | California | 94121-1563 | — |
| VA Connecticut Healthcare System West Haven Campus, West Haven, CT | West Haven | Connecticut | 06516-2770 | — |
| CERC (VISN1, West Haven, CT) | West Haven | Connecticut | 06516 | — |
| Bay Pines VA Healthcare System, Pay Pines, FL | Bay Pines | Florida | 33744-0000 | — |
| Atlanta VA Medical and Rehab Center, Decatur, GA | Decatur | Georgia | 30033 | — |
| Edward Hines Jr. VA Hospital, Hines, IL | Hines | Illinois | 60141-3030 | — |
| Overton Brooks VA Medical Center, Shreveport, LA | Shreveport | Louisiana | 71101 | — |
| VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA | Boston | Massachusetts | 02130-4817 | — |
| Minneapolis VA Health Care System, Minneapolis, MN | Minneapolis | Minnesota | 55417 | — |
| New Mexico VA Health Care System, Albuquerque, NM | Albuquerque | New Mexico | 87108-5153 | — |
| Asheville VA Medical Center, Asheville, NC | Asheville | North Carolina | 28805 | — |
| Durham VA Medical Center, Durham, NC | Durham | North Carolina | 27705-3875 | — |
| Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC | Salisbury | North Carolina | 28144 | — |
| Cincinnati VA Medical Center, Cincinnati, OH | Cincinnati | Ohio | 45220-2213 | — |
| Louis Stokes VA Medical Center, Cleveland, OH | Cleveland | Ohio | 44106 | — |
| Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA | Philadelphia | Pennsylvania | 19104 | — |
| VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA | Pittsburgh | Pennsylvania | 15240 | — |
| Providence VA Medical Center, Providence, RI | Providence | Rhode Island | 02908 | — |
| Ralph H. Johnson VA Medical Center, Charleston, SC | Charleston | South Carolina | 29401-5799 | — |
| VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX | Dallas | Texas | 75216-7167 | — |
| Michael E. DeBakey VA Medical Center, Houston, TX | Houston | Texas | 77030-4211 | — |
| South Texas Health Care System, San Antonio, TX | San Antonio | Texas | 78229 | — |
| VA Salt Lake City Health Care System, Salt Lake City, UT | Salt Lake City | Utah | 84148 | — |
| White River Junction VA Medical Center, White River Junction, VT | White River Junction | Vermont | 05009-0001 | — |
| Salem VA Medical Center, Salem, VA | Salem | Virginia | 24153 | — |
| VA Puget Sound Health Care System Seattle Division, Seattle, WA | Seattle | Washington | 98108 | — |
| William S. Middleton Memorial Veterans Hospital, Madison, WI | Madison | Wisconsin | 53705 | — |
| Clement J. Zablocki VA Medical Center, Milwaukee, WI | Milwaukee | Wisconsin | 53295-0001 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03668041, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 2, 2026 · Synced Sep 26, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03668041 live on ClinicalTrials.gov.