A Phase III Study to Evaluate the Port Delivery System With Ranibizumab Compared With Monthly Ranibizumab Injections in Participants With Wet Age-Related Macular Degeneration
Public ClinicalTrials.gov record NCT03677934. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase III, Multicenter, Randomized, Visual Assessor-Masked, Active-Comparator Study of the Efficacy, Safety, and Pharmacokinetics of the Port Delivery System With Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study GR40548 is a Phase III, randomized, multicenter, open-label (visual assessor \[VA\]-masked), active-comparator study designed to assess the efficacy, safety, and pharmacokinetics (PK) of 100mg/ml delivered via the Port Delivery System with ranibizumab (PDS) compared with ranibizumab intravitreal injections at 0.5 mg (10 mg/mL) in participants with neovascular age-related macular degeneration (nAMD).
Study identification
- NCT ID
- NCT03677934
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 415 participants
Conditions and interventions
Conditions
Interventions
- PDS Implant filled with 100 mg/mL Ranibizumab Drug
- Intravitreal Injections of 10 mg/mL Ranibizumab Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 12, 2018 (Actual)
- Primary completion
- May 22, 2020 (Actual)
- Completion
- Jun 9, 2021 (Actual)
- Last update posted
- Oct 4, 2022
2018 – 2021
United States locations
- U.S. sites
- 77
- U.S. states
- 29
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barnet Dulaney Perkins Eye Center | Mesa | Arizona | 85206 | — |
| Associated Retina Consultants | Phoenix | Arizona | 85020 | — |
| Arizona Retina and Vitreous Consultants | Phoenix | Arizona | 85021 | — |
| Retinal Consultants of Arizona | Phoenix | Arizona | 85053 | — |
| California Retina Consultants | Bakersfield | California | 93309 | — |
| Retina-Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| The Retina Partners | Encino | California | 91436 | — |
| Jules Stein Eye Institute/ UCLA | Los Angeles | California | 90095-7000 | — |
| N CA Retina Vitreous Assoc | Mountain View | California | 94040 | — |
| Retina Consultants, San Diego | Poway | California | 92064 | — |
| Retinal Consultants Med Group | Sacramento | California | 95825 | — |
| West Coast Retina Medical Group | San Francisco | California | 94109 | — |
| UCSF; Ophthalmology | San Francisco | California | 94143 | — |
| Orange County Retina Med Group | Santa Ana | California | 92705 | — |
| California Retina Consultants | Santa Barbara | California | 93103 | — |
| Bay Area Retina Associates | Walnut Creek | California | 94598 | — |
| Southwest Retina Consultants | Durango | Colorado | 81303 | — |
| Eye Center of Northern CO | Fort Collins | Colorado | 80528 | — |
| Colorado Retina Associates, PC | Lakewood | Colorado | 80228 | — |
| Retina Group of New England | Waterford | Connecticut | 06385 | — |
| National Ophthalmic Research Institute | Fort Myers | Florida | 33912 | — |
| Florida Eye Associates | Melbourne | Florida | 32901 | — |
| Retina Care Specialists | Palm Beach Gardens | Florida | 33410 | — |
| Retina Specialty Institute | Pensacola | Florida | 32503 | — |
| Fort Lauderdale Eye Institute | Plantation | Florida | 33324 | — |
| Retina Vitreous Assoc of FL | St. Petersburg | Florida | 33711 | — |
| Southern Vitreoretinal Assoc | Tallahassee | Florida | 32308 | — |
| Retina Associates of Florida, LLC | Tampa | Florida | 33609 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Georgia Retina PC | Marietta | Georgia | 30060 | — |
| Illinois Retina Associates | Joliet | Illinois | 60435 | — |
| University Retina and Macula Associates, PC | Lemont | Illinois | 60439 | — |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266 | — |
| Retina Associates | Lenexa | Kansas | 66215 | — |
| Retina Associates of Kentucky | Lexington | Kentucky | 40509 | — |
| Paducah Retinal Center | Paducah | Kentucky | 42001 | — |
| Maine Eye Center | Portland | Maine | 04101 | — |
| The Retina Care Center | Baltimore | Maryland | 21209 | — |
| Johns Hopkins Med; Wilmer Eye Inst | Baltimore | Maryland | 21287 | — |
| Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Retina Specialists | Towson | Maryland | 21204 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Vitreo-Retinal Associates, PC | Worcester | Massachusetts | 01605 | — |
| Associated Retinal Consultants | Grand Rapids | Michigan | 49546 | — |
| Foundation for Vision Research | Grand Rapids | Michigan | 49546 | — |
| VitreoRetinal Surgery, PLLC.; DBA Retina Consultants of Minnesota | Edina | Minnesota | 55435 | — |
| Midwest Vision Research Foundation | Chesterfield | Missouri | 63017 | — |
| The Retina Institute - Chesterfield | Chesterfield | Missouri | 63017 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Envision Ocular, LLC | Bloomfield | New Jersey | 07003 | — |
| Mid Atlantic Retina - Wills Eye Hospital | Cherry Hill | New Jersey | 08034 | — |
| NJ Retina Teaneck Clinic | Toms River | New Jersey | 08755 | — |
| Long Is. Vitreoretinal Consult | Great Neck | New York | 11021 | — |
| Retina Vit Surgeons/Central NY | Liverpool | New York | 13088 | — |
| Vitreous-Retina-Macula | New York | New York | 10022 | — |
| Ophthalmic Consultants of Long Island | Rockville Centre | New York | 11570 | — |
| Char Eye Ear &Throat Assoc | Charlotte | North Carolina | 28210 | — |
| Cincinnati Eye Institute | Cincinnati | Ohio | 45242 | — |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| OSU Eye Physicians & Surgeons | Columbus | Ohio | 43212 | — |
| Retina Vitreous Center | Edmond | Oklahoma | 73013 | — |
| Retina Northwest | Portland | Oregon | 97221 | — |
| Palmetto Retina Center | Florence | South Carolina | 29501 | — |
| Charles Retina Institute | Memphis | Tennessee | 38119 | — |
| Tennessee Retina PC | Nashville | Tennessee | 37203 | — |
| Texas Retina Associates | Arlington | Texas | 76012 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Austin Clinical Research LLC | Austin | Texas | 78750 | — |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | — |
| Texas Retina Associates | Fort Worth | Texas | 76104 | — |
| Med Center Ophthalmology Assoc | San Antonio | Texas | 78240 | — |
| Retina Associates of Utah | Salt Lake City | Utah | 84107 | — |
| Rocky Mountain Retina | Salt Lake City | Utah | 84107 | — |
| Wagner Macula & Retina Center | Norfolk | Virginia | 23502 | — |
| Retina Institute of Virginia | Richmond | Virginia | 23235 | — |
| Retina Center Northwest | Silverdale | Washington | 98383 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03677934, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 4, 2022 · Synced Oct 29, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03677934 live on ClinicalTrials.gov.