A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
Public ClinicalTrials.gov record NCT03683186. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Open-label Extension (OLE) Study to Evaluate the Long-term Safety and Efficacy of Ralinepag in Subjects With World Health Organization (WHO) Group 1 Pulmonary Arterial Hypertension (PAH)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study ROR-PH-303, ADVANCE EXTENSION, is an open-label extension (OLE) study for participants with WHO Group 1 PAH who have participated in another Phase 2 or Phase 3 study of ralinepag.
Study identification
- NCT ID
- NCT03683186
- Recruitment status
- Enrolling by invitation
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,000 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 23, 2019 (Actual)
- Primary completion
- Dec 2026 (Estimated)
- Completion
- Dec 2026 (Estimated)
- Last update posted
- Oct 6, 2026
2019 – 2026
United States locations
- U.S. sites
- 48
- U.S. states
- 24
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| St. Joseph's Hospital and Medical Center-Norton Thoracic Institute | Phoenix | Arizona | 85013 | — |
| University of Arizona | Tucson | Arizona | 85724 | — |
| UCSD Health Sciences | La Jolla | California | 92037 | — |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90024 | — |
| Keck Hospital of USC | Los Angeles | California | 90033 | — |
| VA Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| University of California, Irvine | Orange | California | 92868 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| Santa Barbara Cottage Hospital | Santa Barbara | California | 93105 | — |
| Stanford University Medical Center | Stanford | California | 94305 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| National Jewish Health | Denver | Colorado | 80206 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Central Florida Pulmonary Group | Orlando | Florida | 32803 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| Piedmont Healthcare Pulmonary and Critical Care Research | Austell | Georgia | 30106 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Ascension Alexian Brothers | Elk Grove Village | Illinois | 60007 | — |
| Community Heart and Vascular Hospital | Indianapolis | Indiana | 46256 | — |
| St. Vincent Medical Group, Inc. | Indianapolis | Indiana | 46260 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Boston University Medical Center | Boston | Massachusetts | 02118 | — |
| Spectrum Health Medical Group | Grand Rapids | Michigan | 49546 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| University of New Mexico | Albuquerque | New Mexico | 87131 | — |
| NYU Langone Medical Center | New York | New York | 10016 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| East Carolina University | Greenville | North Carolina | 27834 | — |
| University of Cincinnati-Medical Science Building | Cincinnati | Ohio | 45267 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Integris Baptist Medical Center | Oklahoma City | Oklahoma | 73112 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| StatCare Pulmonary Consultants | Knoxville | Tennessee | 37919 | — |
| Ascension Texas Cardiovascular | Austin | Texas | 78705 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Memorial Hermann Hospital | Houston | Texas | 77030 | — |
| The Methodist Hospital Research Institute | Houston | Texas | 77030 | — |
| Vermont Lung Center | Burlington | Vermont | 05446 | — |
| Carilion Clinic Pulmonary and Sleep Medicine | Roanoke | Virginia | 24014 | — |
| Medical College of Wisconsin/Froedtert Hospital | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 142 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03683186, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 6, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03683186 live on ClinicalTrials.gov.