Multi-arm Optimization of Stroke Thrombolysis
Public ClinicalTrials.gov record NCT03735979. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Multi-arm Optimization of Stroke Thrombolysis (MOST): a Single Blinded, Randomized Controlled Adaptive, Multi-arm, Adjunctive-thrombolysis Efficacy Trial in Ischemic Stroke
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary efficacy objective of the MOST trial is to determine if argatroban (100µg/kg bolus followed by 3µg/kg per minute for 12 hours) or eptifibatide (135µg/kg bolus followed by 0.75µg/kg/min infusion for two hours) results in improved 90-day modified Rankin scores (mRS) as compared with placebo in acute ischemic stroke (AIS) patients treated with standard of care thrombolysis (0.9mg/kg IV rt-PA or 0.25mg/kg IV tenecteplase or TNK) within three hours of symptom onset. Patients may also receive endovascular thrombectomy (ET) per usual care. Time of onset is defined as the last time the patient was last known to be well.
Study identification
- NCT ID
- NCT03735979
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 514 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 15, 2019 (Actual)
- Primary completion
- Dec 1, 2023 (Actual)
- Completion
- Oct 31, 2024 (Actual)
- Last update posted
- Feb 7, 2025
2019 – 2024
United States locations
- U.S. sites
- 61
- U.S. states
- 23
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Hospital | Birmingham | Alabama | 35233 | — |
| St. Jude Medical Center | Fullerton | California | 92835 | — |
| UCSD Health La Jolla | La Jolla | California | 92037 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| UC Irvine Medical Center | Orange | California | 92868 | — |
| UCSD Medical Center - Hillcrest Hospital | San Diego | California | 92103 | — |
| San Francisco General Hospital | San Francisco | California | 94110 | — |
| UCSF Medical Center | San Francisco | California | 94143 | — |
| Santa Barbara Cottage Hospital | Santa Barbara | California | 93105 | — |
| Yale New Haven Hospital | New Haven | Connecticut | 06510 | — |
| Baptist Medical Center Jacksonville | Jacksonville | Florida | 32207 | — |
| Mayo Clinic Hospital | Jacksonville | Florida | 32224 | — |
| Jackson Memorial Hospital | Miami | Florida | 33136 | — |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Javon Bea Hospital - Riverside | Rockford | Illinois | 61114 | — |
| Central DuPage Hospital | Winfield | Illinois | 60190 | — |
| University of Kansas Hospital | Kansas City | Kansas | 66160 | — |
| University of Kentucky Hospital | Lexington | Kentucky | 40536 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| UMASS Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| University of Michigan University Hospital | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| McLaren Flint | Flint | Michigan | 48532 | — |
| Trinity Health Saint Mary's | Grand Rapids | Michigan | 49503 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55425 | — |
| University of Minnesota Medical Center Hospital | Minneapolis | Minnesota | 55455 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Saint Luke's Hospital | Kansas City | Missouri | 64111 | — |
| St. Louis University Hospital | St Louis | Missouri | 63108 | — |
| Barnes Jewish Hospital | St Louis | Missouri | 63110 | — |
| University of New Mexico Hospital | Albuquerque | New Mexico | 87106 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| Mount Sinai Beth Israel | New York | New York | 10003 | — |
| SUNY Upstate University Hospital | Syracuse | New York | 13210 | — |
| Forsyth Medical Center | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | 27103 | — |
| Cleveland Clinic Akron General | Akron | Ohio | 44307 | — |
| Mercy Health West Hospital | Cincinnati | Ohio | 45211 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | — |
| The Jewish Hospital | Cincinnati | Ohio | 45236 | — |
| OSU Wexner Medical Center | Columbus | Ohio | 43210 | — |
| St. John Medical Center | Tulsa | Oklahoma | 74104 | — |
| Abington Memorial Hospital | Abington | Pennsylvania | 19001 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| UPMC Presbyterian Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC Mercy Hospital | Pittsburgh | Pennsylvania | 15219 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Prisma Health Greenville Memorial Hospital | Greenville | South Carolina | 29605 | — |
| Vanderbilt University Hospital | Nashville | Tennessee | 37232 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Memorial Hermann-Texas Medical Center | Houston | Texas | 77030 | — |
| South Texas Health System McAllen | McAllen | Texas | 78503 | — |
| University of Utah Healthcare | Salt Lake City | Utah | 84132 | — |
| UVA Medical Center | Charlottesville | Virginia | 22908 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03735979, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 7, 2025 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03735979 live on ClinicalTrials.gov.