Clazakizumab for the Treatment of Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients
Public ClinicalTrials.gov record NCT03744910. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Pivotal Phase 3 Trial to Evaluate the Safety and Efficacy of Clazakizumab for the Treatment of Chronic Active Antibody-mediated Rejection in Kidney Transplant Recipients
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This trial investigates the efficacy and safety of clazakizumab \[an anti-interleukin (IL)-6 monoclonal antibody (mAb)\] for the treatment of CABMR in recipients of a kidney transplant.
Study identification
- NCT ID
- NCT03744910
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 194 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 14, 2019 (Actual)
- Primary completion
- Apr 8, 2024 (Actual)
- Completion
- Apr 8, 2024 (Actual)
- Last update posted
- Jul 23, 2025
2019 – 2024
United States locations
- U.S. sites
- 49
- U.S. states
- 26
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham (UAB) - University of Alabama Hospital (UAB Hospital) | Birmingham | Alabama | 35294 | — |
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | — |
| Keck Medical Center Of USC | Los Angeles | California | 90033 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| UCLA Kidney Transplant Research Program | Los Angeles | California | 90095 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| California Institute of Renal Research | San Diego | California | 92123 | — |
| North America Research Institute | San Dimas | California | 91773 | — |
| California Pacific Medical Center | San Francisco | California | 94109 | — |
| Kaiser Permanente | San Francisco | California | 94118 | — |
| University of California, San Francisco Medical Center | San Francisco | California | 94143 | — |
| University Of Colorado Hospital - Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Tampa General Medical Group | Tampa | Florida | 33606 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Rush University Medical Center - University Cardiovascular Surgeons | Chicago | Illinois | 60612 | — |
| Indiana University (IU) Health Physicians - Kidney Diseases Clinic - Medical Diagnostic Center Location | Indianapolis | Indiana | 46202 | — |
| Unity Point Health | Des Moines | Iowa | 50309 | — |
| Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Louisville Research Foundation | Louisville | Kentucky | 40202 | — |
| Tulane University Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Massachusetts General Cancer Center | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55095 | — |
| Washington University School of Medicine - Infectious Diseases (WU ID) Clinic | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68105 | — |
| Saint Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| Erie County Medical Center Corp. | Buffalo | New York | 14215 | — |
| NYU Langone Medical Center | New York | New York | 10016 | — |
| New York Presbyterian Hospital / Weill Cornell Medical Center | New York | New York | 10021 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Duke Cancer Institute | Durham | North Carolina | 27710 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| The Ohio State University, Comprehensive Transplant Center | Columbus | Ohio | 43210 | — |
| University of Cincinnati | Toledo | Ohio | 43614 | — |
| Integris Baptist Medical Center | Oklahoma City | Oklahoma | 73112 | — |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | — |
| Central Pennsylvania Transplant Foundation | Harrisburg | Pennsylvania | 17104 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02906 | — |
| Renal Disease Research Institute | Dallas | Texas | 75204 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75235 | — |
| Methodist Healthcare System of San Antonio | San Antonio | Texas | 78229 | — |
| VCU Health | Richmond | Virginia | 23298 | — |
| University of Washington | Seattle | Washington | 98195 | — |
| University of Wisconsin School of Medicine and Public Health (UWSMPH) | Madison | Wisconsin | 53705 | — |
| Medical College of WI Froedtert Hospital | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 93 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03744910, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 23, 2025 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03744910 live on ClinicalTrials.gov.