A Study to Evaluate the Safety and Efficacy of BIIB104 in Participants With Cognitive Impairment Associated With Schizophrenia (CIAS)
Public ClinicalTrials.gov record NCT03745820. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-Blind, Multiple-Dose, Placebo-Controlled Study to Evaluate the Safety and Efficacy of BIIB104 in Subjects With Cognitive Impairment Associated With Schizophrenia (CIAS)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the study is to evaluate the efficacy of BIIB104 in participants with CIAS, using the Working Memory Domain of the MATRICS Consensus Cognitive Battery (MCCB). The secondary objectives of this study are to evaluate the safety and tolerability of BIIB104 in participants with CIAS, and to evaluate the efficacy of BIIB104 in participants with CIAS on measures of cognition, functioning, and psychiatric symptomology.
Study identification
- NCT ID
- NCT03745820
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 195 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 15, 2018 (Actual)
- Primary completion
- Mar 23, 2022 (Actual)
- Completion
- Apr 7, 2022 (Actual)
- Last update posted
- Apr 18, 2023
2018 – 2022
United States locations
- U.S. sites
- 37
- U.S. states
- 15
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pillar Clinical Research, LLC | Bentonville | Arkansas | 72712 | — |
| ProScience Research Group | Culver City | California | 90230 | — |
| Collaborative Neuroscience Network, LLC | Garden Grove | California | 92845 | — |
| Synergy San Diego | Lemon Grove | California | 91945 | — |
| Research Site | Long Beach | California | 90807 | — |
| Catalina Research Institute, LLC | Montclair | California | 91763 | — |
| Excell Research | Oceanside | California | 92056 | — |
| Research Site | Pico Rivera | California | 90660 | — |
| CNRI - San Diego, LLC | San Diego | California | 92102 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92103 | — |
| Research Site | San Diego | California | 92123 | — |
| Research Site | San Rafael | California | 94901 | — |
| Research Site | Torrance | California | 90502 | — |
| Yale University, Department of Psychiatry | New Haven | Connecticut | 06519 | — |
| Research Site | Lauderhill | Florida | 33319 | — |
| Premier Clinical Research Institute, Inc. | Miami | Florida | 33122 | — |
| Stedman Clinical Trials | Tampa | Florida | 33613 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30331 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| Research Site | Decatur | Georgia | 30030 | — |
| Research Site | Chicago | Illinois | 60611 | — |
| Alexian Brothers Hospital Network | Hoffman Estates | Illinois | 60169 | — |
| Southern Illinois University, School of Medicine | Springfield | Illinois | 62702 | — |
| Research Site | Gaithersburg | Maryland | 20877 | — |
| Cherry Health | Grand Rapids | Michigan | 49503 | — |
| Research Site | Flowood | Mississippi | 39232 | — |
| Research Site | St Louis | Missouri | 63128 | — |
| St. Louis Clinical Trials, LC | St Louis | Missouri | 63141 | — |
| Hassman Research Institute | Berlin | New Jersey | 08009 | — |
| UB Department Psychiatry | Buffalo | New York | 104051 | — |
| Neurobehavioral Research, Inc. | Cedarhurst | New York | 11516 | — |
| Finger Lakes Clinical Research | Rochester | New York | 14618 | — |
| The Ohio State University Department of Psychiatry | Columbus | Ohio | 43210 | — |
| Research Site | North Canton | Ohio | 44720 | — |
| Research Site | Richardson | Texas | 75080 | — |
| The University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78207 | — |
| Research Site | Kirkland | Washington | 98033 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 23 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03745820, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 18, 2023 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03745820 live on ClinicalTrials.gov.