An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Crohn's Disease
Public ClinicalTrials.gov record NCT03759288. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 52-Week, Multicenter, Randomized, Double-blind, Placebo and Active-Controlled, Operationally Seamless Phase 2b/3, Parallel-group Study to Assess the Efficacy and Safety of Brazikumab in Participants With Moderately to Severely Active Crohn's Disease (INTREPID Lead-In)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study seeks to evaluate the safety and efficacy of brazikumab versus placebo (Stage I) and versus an active comparator (Stage 2) in participants with moderately to severely active CD and will include assessments of clinical response as demonstrated by improvement of symptoms and colonic mucosal appearance as observed on endoscopy
Study identification
- NCT ID
- NCT03759288
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 89 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 7, 2018 (Actual)
- Primary completion
- Oct 18, 2023 (Actual)
- Completion
- Oct 18, 2023 (Actual)
- Last update posted
- Jun 23, 2026
2018 – 2023
United States locations
- U.S. sites
- 38
- U.S. states
- 18
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Phoenix | Arizona | 85037 | — |
| Research Site | Little Rock | Arkansas | 72212 | — |
| Research Site | Lancaster | California | 93534 | — |
| Research Site | Lincoln | California | 95648 | — |
| Research Site | Poway | California | 92064 | — |
| Research Site | San Diego | California | 92103 | — |
| Research Site | Colorado Springs | Colorado | 80907 | — |
| Research Site | Boca Raton | Florida | 33487 | — |
| Research Site | Clearwater | Florida | 33756 | — |
| Research Site | Kissimmee | Florida | 34741 | — |
| Research Site | Lakeland | Florida | 33813 | — |
| Research Site | Miami | Florida | 33157 | — |
| Research Site | Miami | Florida | 33165 | — |
| Research Site | Miami | Florida | 33189 | — |
| Research Site | Miami Lakes | Florida | 33016 | — |
| Research Site | Naples | Florida | 34102 | — |
| Research Site | St. Petersburg | Florida | 33710 | — |
| Research Site | Tampa | Florida | 33626 | — |
| Research Site | Atlanta | Georgia | 30328 | — |
| Research Site | Atlanta | Georgia | 30342 | — |
| Research Site | Decatur | Georgia | 30033 | — |
| Research Site | Oak Lawn | Illinois | 60453 | — |
| Research Site | Brownsburg | Indiana | 46112 | — |
| Research Site | Chesterfield | Michigan | 48047 | — |
| Research Site | Las Vegas | Nevada | 89123 | — |
| Research Site | Albuquerque | New Mexico | 87108 | — |
| Research Site | Morehead City | North Carolina | 28557 | — |
| Research Site | Beachwood | Ohio | 44122 | — |
| Research Site | Oklahoma City | Oklahoma | 73102 | — |
| Research Site | Uniontown | Pennsylvania | 15401 | — |
| Research Site | Carrollton | Texas | 75007 | — |
| Research Site | Houston | Texas | 77017 | — |
| Research Site | Houston | Texas | 77058 | — |
| Research Site | McAllen | Texas | 78503 | — |
| Research Site | Pflugerville | Texas | 78660 | — |
| Research Site | Stafford | Texas | 77477 | — |
| Research Site | North Chesterfield | Virginia | 23236 | — |
| Research Site | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 64 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03759288, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 23, 2026 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03759288 live on ClinicalTrials.gov.