Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Alone or in Combination With Sulfonylurea
Public ClinicalTrials.gov record NCT03770728. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 30-week, Multicenter, Double-blind, Placebo-controlled, Randomized Study to Evaluate the Efficacy and Safety of Efpeglenatide Once Weekly in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Alone or in Combination With Sulfonylurea
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Primary Objective: To demonstrate the superiority of once weekly injection of efpeglenatide in comparison to placebo in glycated hemoglobin (HbA1c) change in participants with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin alone or in combination with sulfonylurea (SU). Secondary Objectives: * To demonstrate the superiority of once weekly injection of efpeglenatide in comparison to placebo on glycemic control. * To demonstrate the superiority of once weekly injection of efpeglenatide in comparison to placebo on body weight. * To evaluate the safety of once weekly injection of efpeglenatide.
Study identification
- NCT ID
- NCT03770728
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 312 participants
Conditions and interventions
Conditions
Interventions
- Efpeglenatide SAR439977 Drug
- Placebo Drug
- Background therapy: Metformin alone or in combination with SU Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 31, 2019
- Primary completion
- Nov 27, 2020
- Completion
- Dec 26, 2020
- Last update posted
- Dec 1, 2021
2019 – 2020
United States locations
- U.S. sites
- 23
- U.S. states
- 14
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Investigational Site Number 8400038 | Birmingham | Alabama | 35211 | — |
| Investigational Site Number 8400035 | Chandler | Arizona | 85224 | — |
| Investigational Site Number 8400005 | Glendale | Arizona | 85306 | — |
| Investigational Site Number 8400042 | Mesa | Arizona | 85206 | — |
| Investigational Site Number 8400051 | Phoenix | Arizona | 85020 | — |
| Investigational Site Number 8400056 | Tucson | Arizona | 85741 | — |
| Investigational Site Number 8400057 | Huntington Park | California | 90255 | — |
| Investigational Site Number 8400009 | Los Angeles | California | 90057 | — |
| Investigational Site Number 8400045 | Spring Valley | California | 91978 | — |
| Investigational Site Number 8400040 | Tustin | California | 92780 | — |
| Investigational Site Number 8400047 | Colorado Springs | Colorado | 80909 | — |
| Investigational Site Number 8400046 | Coral Gables | Florida | 33134 | — |
| Investigational Site Number 8400041 | Pembroke Pines | Florida | 33026 | — |
| Investigational Site Number 8400025 | Lawrenceville | Georgia | 30044 | — |
| Investigational Site Number 8400044 | Lexington | Kentucky | 40503 | — |
| Investigational Site Number 8400001 | Bridgeton | New Jersey | 08302 | — |
| Investigational Site Number 8400039 | New Windsor | New York | 12553 | — |
| Investigational Site Number 8400036 | Morehead City | North Carolina | 28557 | — |
| Investigational Site Number 8400013 | Maumee | Ohio | 43537 | — |
| Investigational Site Number 8400048 | Oklahoma City | Oklahoma | 73111 | — |
| Investigational Site Number 8400030 | Dallas | Texas | 75230 | — |
| Investigational Site Number 8400043 | San Antonio | Texas | 78229 | — |
| Investigational Site Number 8400037 | Layton | Utah | 84041 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 25 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03770728, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 1, 2021 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03770728 live on ClinicalTrials.gov.