A Trial of Enzastaurin Plus Temozolomide During and Following Radiation Therapy in Patients With Newly Diagnosed Glioblastoma With or Without the Novel Genomic Biomarker, DGM1
Public ClinicalTrials.gov record NCT03776071. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients Who Possess the Novel Genomic Biomarker DGM1
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will be conducted as a randomized, double-blind, placebo-controlled, multi-center Phase 3 study. Approximately 300 subjects with newly diagnosed glioblastoma who meet all eligibility criteria will be enrolled.
Study identification
- NCT ID
- NCT03776071
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 260 participants
Conditions and interventions
Conditions
Interventions
- Enzastaurin Hydrochloride Drug
- Placebo Other
- Temozolomide Drug
- Radiotherapy Radiation
Drug · Other · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 15, 2020
- Primary completion
- Feb 28, 2024
- Completion
- Feb 28, 2024
- Last update posted
- Apr 21, 2024
2020 – 2024
United States locations
- U.S. sites
- 47
- U.S. states
- 21
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| Mayo Clinic - Arizona | Scottsdale | Arizona | 85259 | — |
| City of Hope Comprehensive Cancer Center - Duarte | Duarte | California | 91010 | — |
| University of California San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California Irvine Health Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| The University of Southern California | Pasadena | California | 91105 | — |
| University of California San Francisco Helen Diller Family Comprehensive CA Ctr | San Francisco | California | 94143 | — |
| University of Colorado Hospital Anschutz Cancer Pavilion | Aurora | Colorado | 80045 | — |
| Blue Sky Neurology | Englewood | Colorado | 80220 | — |
| Smilow Cancer Hospital - New Haven | New Haven | Connecticut | 06511 | — |
| Lynn Cancer Institute | Boca Raton | Florida | 33486 | — |
| Mayo Clinic - Jacksonville | Jacksonville | Florida | 32224-1865 | — |
| Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | — |
| Miami Cancer Institute | Miami | Florida | 33176 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Winship Cancer Institute of Emory University | Atlanta | Georgia | 30322 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Kentucky Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| Norton Cancer Institute - Multidisciplinary Clinic | Louisville | Kentucky | 40202 | — |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| John Nasseff Neuroscience Institute | Minneapolis | Minnesota | 55407 | — |
| Masonic Cancer Center | Minneapolis | Minnesota | 55455-4800 | — |
| Mayo Clinic - Rochester | Rochester | Minnesota | 55905 | — |
| Washington University School of Medicine Center for Advanced Medicine | St Louis | Missouri | 63110 | — |
| Hackensack Meridian Health - JFK Medical Center | Edison | New Jersey | 08820 | — |
| New York University Medical Oncology Associates | New York | New York | 10016 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| New York - Presbyterian - Weill Cornell Medical Center | New York | New York | 10065 | — |
| Messino Cancer Centers | Asheville | North Carolina | 28806 | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599-7055 | — |
| Wake Forest Baptist Health - Comprehensive Cancer Center | Winston-Salem | North Carolina | 27157 | — |
| The Ohio State University - The James Cancer Hospital and Solove Research Institute | Columbus | Ohio | 43210 | — |
| Penn State Health Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Penn Medicine - Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh Medical Center - Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| SCRI - Tennessee Oncology - Nashville - Centennial | Nashville | Tennessee | 37203-1625 | — |
| Vanderbilt - Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| Austin Cancer Center - Park St. David's | Austin | Texas | 78705 | — |
| Baylor University Medical Center | Dallas | Texas | 75246 | — |
| Lynn Cancer Institute | Houston | Texas | 77030 | — |
| University of Texas Health Science Center at Houston (UT Health) | Houston | Texas | 77030 | — |
| Mays Cancer Center | San Antonio | Texas | 78229 | — |
| University of Utah | Salt Lake City | Utah | 84112 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109--1023 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 18 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03776071, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 21, 2024 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03776071 live on ClinicalTrials.gov.