ClinicalTrials.gov record
12-Week Placebo-controlled Study of Atogepant for the Preventive Treatment of Migraine in Participants With Episodic Migraine
ClinicalTrials.gov ID: NCT03777059
Public ClinicalTrials.gov record NCT03777059. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy, Safety, and Tolerability of Oral Atogepant for the Prevention of Migraine in Participants With Episodic Migraine (ADVANCE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To evaluate the safety and tolerability of atogepant 30 mg and 60 mg once a day for the prevention of migraine in participants with episodic migraine.
Study identification
- NCT ID
- NCT03777059
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 910 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 14, 2018 (Actual)
- Primary completion
- Jun 19, 2020 (Actual)
- Completion
- Jun 19, 2020 (Actual)
- Last update posted
- Jul 9, 2021
2018 – 2020
United States locations
- U.S. sites
- 138
- U.S. states
- 34
- U.S. cities
- 115
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Synexus Clinical Research US, Inc. | Chandler | Arizona | 85224 | — |
| Advanced Research Associates | Glendale | Arizona | 85308 | — |
| Alea Research Institute | Phoenix | Arizona | 85012 | — |
| Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| Orange Grove Family Practice | Tucson | Arizona | 85741 | — |
| Principals Research Group | Hot Springs | Arkansas | 71901 | — |
| Arkansas Clinical Research | Little Rock | Arkansas | 72205 | — |
| Baptist Health Center for Clinical Research | Little Rock | Arkansas | 72205 | — |
| Med Center Medical Clinic | Carmichael | California | 95608 | — |
| Triwest Research Associates | El Cajon | California | 92020 | — |
| Neuro Pain Medical Center | Fresno | California | 93710 | — |
| California Headache and Balance Center | Fresno | California | 93720 | — |
| Fullerton Neurology and Headache Center | Fullerton | California | 92835 | — |
| Neurology Center of North Orange County | Fullerton | California | 92835 | — |
| NervePro Research Bruce Cleeremans | Irvine | California | 92618 | — |
| Grossmont Center for Clinical Research | La Mesa | California | 91942 | — |
| Torrance Clinical Research Institute, Inc. | Lomita | California | 90731 | — |
| Long Beach Clinical Trials Services | Long Beach | California | 90806 | — |
| Keck Medicine of USC | Los Angeles | California | 90033 | — |
| Pharmacology Research Institute | Newport Beach | California | 92660 | — |
| Newport Beach Clinical Research Associates | Newport Beach | California | 92663 | — |
| Excell Research, Inc. | Oceanside | California | 92056 | — |
| Stanford | Palo Alto | California | 94304 | — |
| Rancho Cucamonga Clinical Research | Rancho Cucamonga | California | 91730 | — |
| Desert Valley Research | Redlands | California | 92374 | — |
| George J. Rederich, M.D. Inc. | Redondo Beach | California | 90277 | — |
| Paradigm Clinical Research Centers, Inc | San Diego | California | 92117 | — |
| Optimus Medical Group | San Francisco | California | 94102 | — |
| California Neuroscience Research | Sherman Oaks | California | 91403 | — |
| Synexus Clinical Research US, Inc. | Vista | California | 92083 | — |
| Colorado Springs Neurological Associates | Colorado Springs | Colorado | 80907 | — |
| Delta Waves, Inc. | Colorado Springs | Colorado | 80918 | — |
| Colorado Neurological Institute | Englewood | Colorado | 80113 | — |
| New England Institute for Clinical Research | Stamford | Connecticut | 06905 | — |
| Aventura Neurological Associates | Aventura | Florida | 33180 | — |
| Neurology Offices of South Florida | Boca Raton | Florida | 33428 | — |
| Sarkis Clinical Trials- Gainesville | Gainesville | Florida | 32607 | — |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | — |
| Clinical Neuroscience Solutions, Inc. | Jacksonville | Florida | 32256 | — |
| Neurology Associates, P.A. | Maitland | Florida | 32751 | — |
| Well Pharma Medical Research, Corp. | Miami | Florida | 33143 | — |
| Clinical Neuroscience Solutions | Orlando | Florida | 32801 | — |
| Neurology Associates of Ormond Beach | Ormond Beach | Florida | 32174 | — |
| Sarasota Memorial Hospital Clinical Research Center | Sarasota | Florida | 34239 | — |
| Meridien Research | St. Petersburg | Florida | 33709 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| University of South Florida | Tampa | Florida | 33612 | — |
| Neurotrials Research | Atlanta | Georgia | 30328 | — |
| Pediatric and Adolescent NeuroDevelopmental Associates (PANDA) Neurology | Atlanta | Georgia | 30328 | — |
| Synexus Clinical Research US, Inc. | Atlanta | Georgia | 30328 | — |
| Meridian Clinical Research, LLC | Savannah | Georgia | 31406 | — |
| Diamond Headache Clinic Ltd | Chicago | Illinois | 60642 | — |
| Clinical Investigation Specialists | Gurnee | Illinois | 60031 | — |
| JWM Neurology | Indianapolis | Indiana | 46256 | — |
| Deaconess Clinic - Gateway Health Center | Newburgh | Indiana | 47630 | — |
| PMG Research, Inc. d/b/a PMG Research of McFarland Clinic | Ames | Iowa | 50010 | — |
| Heartland Research Associates, LLC | Newton | Kansas | 67114 | — |
| College Park Family Care Center | Overland Park | Kansas | 66212 | — |
| Phoenix Medical Research | Prairie Village | Kansas | 66208 | — |
| Heartland Research Associates, LLC - An AMR Company | Wichita | Kansas | 67205 | — |
| Heartland Research Associates, LLC - An AMR Company | Wichita | Kansas | 67207 | — |
| Ochsner Clinic Foundation | Covington | Louisiana | 70433 | — |
| New Orleans Center for Clinical Research | New Orleans | Louisiana | 70119 | — |
| DelRicht Research | New Orleans | Louisiana | 70124 | — |
| Pharmasite Research, Inc. | Baltimore | Maryland | 21208 | — |
| Mid-Atlantic Permanente Medical Group, PC | Largo | Maryland | 20774 | — |
| John R. Graham Headache Center Brigham and Women's Faulkner Hospital | Boston | Massachusetts | 02130 | — |
| BTC of New Bedford | New Bedford | Massachusetts | 02740 | — |
| Minneapolis Clinic of Neurology | Golden Valley | Minnesota | 55422 | — |
| Clinical Research Institute | Minneapolis | Minnesota | 55402 | — |
| Synexus Usa | Bay Saint Louis | Mississippi | 63141 | — |
| The Headache Center | Ridgeland | Mississippi | 39157 | — |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | — |
| Clinvest Research LLC. | Springfield | Missouri | 65810 | — |
| Synexus Clinical Research US, Inc. | Omaha | Nebraska | 68144 | — |
| Nevada Headache Institute | Las Vegas | Nevada | 89113 | — |
| Bio Behavioral Health | Toms River | New Jersey | 08755 | — |
| Albuquerque Clinical Trials | Albuquerque | New Mexico | 87102 | — |
| Dent Neurologic Institute | Amherst | New York | 14226 | — |
| Northwell Health | Great Neck | New York | 11021 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| PMG Research of Charlotte, LLC | Charlotte | North Carolina | 28209 | — |
| Guilford Neurologic Associates, Inc | Greensboro | North Carolina | 27405 | — |
| Raleigh Neurology Associates, P.A. | Raleigh | North Carolina | 27607 | — |
| PMG Research of Raleigh, LLC | Raleigh | North Carolina | 27609 | — |
| PMG Research of Rocky Mount, LLC | Rocky Mount | North Carolina | 27804 | — |
| Wilmington Health, PLLC | Wilmington | North Carolina | 28401 | — |
| Piedmont Medical Research of Winston-Salem | Winston-Salem | North Carolina | 27103 | — |
| Synexus Clinical Research US, Inc. | Akron | Ohio | 44311 | — |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | — |
| Patient Priority Clinical Sites | Cincinnati | Ohio | 45215 | — |
| University of Cincinnati | Cincinnati | Ohio | 45219 | — |
| Sentral Clinical Research Services | Cincinnati | Ohio | 45242 | — |
| Aventiv Research Inc | Columbus | Ohio | 43213 | — |
| Family Physicians Associates | Lyndhurst | Ohio | 44124 | — |
| OK Clinical Research, LLC | Edmond | Oklahoma | 73034 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73069 | — |
| Centennial Health-Synexus | Oklahoma City | Oklahoma | 73111 | — |
| Tulsa Clinical Research | Tulsa | Oklahoma | 74104 | — |
| Oregon Center for Clinical Investigations | Portland | Oregon | 97214 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Preferred Primary Care Physicians | Pittsburgh | Pennsylvania | 15236 | — |
| Frontier Clinical Research, LLC | Smithfield | Pennsylvania | 15478 | — |
| Preferred Primary Care Physicians, Jacob Murphy | Uniontown | Pennsylvania | 15401 | — |
| Abington Neurological Associates | Willow Grove | Pennsylvania | 19090 | — |
| Partners in Clinical Research | Cumberland | Rhode Island | 02864 | — |
| Ocean State Clinical Research Partners | Lincoln | Rhode Island | 02865 | — |
| Primary Care Associates/Synexus Clinical | Anderson | South Carolina | 29621 | — |
| Synexus Clinical Research US, Inc | Anderson | South Carolina | 29621 | — |
| Clinical Trials of South Carolina | Charleston | South Carolina | 29406 | — |
| Hillcrest Family Practice | Simpsonville | South Carolina | 29681 | — |
| ClinSearch | Chattanooga | Tennessee | 37421 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| CNS Healthcare - Memphis | Memphis | Tennessee | 38119 | — |
| Psychiatry & Psychotherapy Partners Austin | Austin | Texas | 78737 | — |
| Tekton Research | Austin | Texas | 78745 | — |
| Synexus-US | Dallas | Texas | 75234 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Ventavia Research Group | Fort Worth | Texas | 76104 | — |
| Centex Studies, Inc. | Houston | Texas | 77058 | — |
| Protenium Clinical Research | Hurst | Texas | 76054 | — |
| Clinical Trials of Texas | San Antonio | Texas | 78229 | — |
| Synexus Clinical Research US, Inc. | San Antonio | Texas | 78229 | — |
| ClinPoint Trials | Waxahachie | Texas | 75165 | — |
| Synexus-US | Murray | Utah | 84123 | — |
| J. Lewis Research, Inc. / Foothill Family Clinic South | Salt Lake City | Utah | 84121 | — |
| Highland Clinical Research | Salt Lake City | Utah | 84124 | — |
| J. Lewis Research, Inc. | South Jordan | Utah | 84095 | — |
| Charlottesville Medical Research | Charlottesville | Virginia | 22911 | — |
| Health Research of Hampton Roads, Inc. | Newport News | Virginia | 23606 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23219 | — |
| National Clinical Research, Inc | Richmond | Virginia | 23294 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Sentara Family Medicine Physicians | Virginia Beach | Virginia | 23456 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98004 | — |
| Eastside Therapeutic Resource and Core Clinical Research | Everett | Washington | 98201 | — |
| The Polyclinic | Seattle | Washington | 98104 | — |
| Puget Sound Neurology | Tacoma | Washington | 25328 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03777059, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 9, 2021 · Synced Nov 10, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03777059 live on ClinicalTrials.gov.