Botulinum Toxin Type A (AGN-151607) for the Prevention of Post-operative Atrial Fibrillation in Adult Participants Undergoing Open-chest Cardiac Surgery (NOVA)
Public ClinicalTrials.gov record NCT03779841. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of Botulinum Toxin Type A (AGN-151607) Injections Into the Epicardial Fat Pads to Prevent Post-Operative Atrial Fibrillation in Patients Undergoing Open-Chest Cardiac Surgery
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This was a multi-center, randomized, double-blind, placebo-controlled, parallel group, dose-ranging study to evaluate the efficacy and safety of botulinum toxin type A (AGN-151607) injections into the epicardial fat pads, foci of ganglionic plexi, to prevent Post-Operative Atrial Fibrillation (POAF) in patients undergoing open-chest cardiac surgery.
Study identification
- NCT ID
- NCT03779841
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 323 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 55 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 1, 2019 (Actual)
- Primary completion
- Mar 24, 2022 (Actual)
- Completion
- Mar 6, 2023 (Actual)
- Last update posted
- May 14, 2024
2019 – 2023
United States locations
- U.S. sites
- 19
- U.S. states
- 17
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Stanford University School of Med /ID# 236922 | Stanford | California | 94305-2200 | — |
| Yale New Haven Hospital - Yale School of Medicine /ID# 238221 | New Haven | Connecticut | 06510-3206 | — |
| Medstar Washington Hospital Center /ID# 234322 | Washington D.C. | District of Columbia | 20010-3017 | — |
| Emory Saint Joseph's Hospital /ID# 234334 | Atlanta | Georgia | 30342-1731 | — |
| Lutheran Medical Group /ID# 237990 | Fort Wayne | Indiana | 46804 | — |
| Ochsner Medical Center /ID# 238004 | New Orleans | Louisiana | 70121-2429 | — |
| University of Maryland Medical Center /ID# 234352 | Baltimore | Maryland | 21201-1544 | — |
| University of Michigan /ID# 236228 | Ann Arbor | Michigan | 48109-5000 | — |
| Washington University-School of Medicine /ID# 238121 | St Louis | Missouri | 63110 | — |
| Dartmouth-Hitchcock Medical Center /ID# 237530 | Lebanon | New Hampshire | 03756 | — |
| Icahn School of Medicine at Mount Sinai - The Mount Sinai Medical Center /ID# 234449 | New York | New York | 10029 | — |
| Mission Hospital /ID# 237231 | Asheville | North Carolina | 28801 | — |
| Duke University Medical Center /ID# 234314 | Durham | North Carolina | 27705-4410 | — |
| East Carolina University /ID# 237820 | Greenville | North Carolina | 27858 | — |
| Ohio State University Medical Center /ID# 234408 | Columbus | Ohio | 43210 | — |
| Medical University of South Carolina /ID# 236476 | Charleston | South Carolina | 29425 | — |
| Baylor Scott & White Research Institute /ID# 235937 | Plano | Texas | 75093 | — |
| University of Utah /ID# 237601 | Salt Lake City | Utah | 84112-5500 | — |
| University of Virginia /ID# 237611 | Charlottesville | Virginia | 22908 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 13 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03779841, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 14, 2024 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03779841 live on ClinicalTrials.gov.