Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps
Public ClinicalTrials.gov record NCT03781804. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 24-Week Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study Evaluating the Efficacy and Safety of Intranasal Administration of 186 and 372 μg of OPN-375 Twice a Day (BID) in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps
Study identification
- NCT ID
- NCT03781804
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Optinose US Inc.
- Industry
- Enrollment
- 332 participants
Conditions and interventions
Conditions
Interventions
- OPN-375 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 26, 2018
- Primary completion
- Jan 18, 2022
- Completion
- Jan 18, 2022
- Last update posted
- May 28, 2024
2018 – 2022
United States locations
- U.S. sites
- 46
- U.S. states
- 26
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AZ Allergy & Immunology Research | Gilbert | Arizona | 85234 | — |
| Kern Research | Bakersfield | California | 93301 | — |
| Sacramento Ear, Nose & Throat Surgical and Medical Group Inc | Folsom | California | 95630 | — |
| Allergy & Asthma Specialists Medical Group | Huntington Beach | California | 92647 | — |
| Jonathan Corren, MD, Clinical Research Division | Los Angeles | California | 90025 | — |
| Sacramento Ear, Nose & Throat | Roseville | California | 95661 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| Allergy and Asthma Associates of Santa Clara Valley | San Jose | California | 95117 | — |
| Breathe Clear Institute | Torrance | California | 90503 | — |
| Allergy & Asthma Clinical Research | Walnut Creek | California | 94598 | — |
| Colorado ENT & Allergy | Colorado Springs | Colorado | 80909 | — |
| Yale School of Medicine Section of Otolaryngology | New Haven | Connecticut | 06519 | — |
| Emory University MOT | Atlanta | Georgia | 30308 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| The University of Chicago | Chicago | Illinois | 60637 | — |
| Midwest Allergy Sinus Asthma | Normal | Illinois | 61761 | — |
| Advanced ENT and Allergy | New Albany | Indiana | 47150 | — |
| Iowa Head & Neck | Des Moines | Iowa | 50312-3505 | — |
| Kentuckiana Ear Nose & Throat | Louisville | Kentucky | 40205 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| John Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Ear, Nose and Throat Associates at Greater Baltimore Medical Center | Towson | Maryland | 21204 | — |
| St. Cloud Ear, Nose & Throat | Saint Cloud | Minnesota | 56303 | — |
| University of Missouri, Dept of Otorlaryngology | Columbia | Missouri | 65212 | — |
| Asthma, Allergy, and Immunology Associates, PC | Lincoln | Nebraska | 68505 | — |
| Atlantic Research Center | Ocean City | New Jersey | 07712 | — |
| ENT and Allergy Associates | New Hyde Park | New York | 11042 | — |
| Mount Sinai Downtown Union Square | New York | New York | 10003 | — |
| Madison ENT and Facial Plastic Surgery | New York | New York | 10016 | — |
| Allergy Asthma & Immunology Relief of Charlotte | Charlotte | North Carolina | 28204 | — |
| Allergy Asthma & Clinical Research Center | Oklahoma City | Oklahoma | 73120 | — |
| Vital Prospects Clinical Research Institute, P.C. | Tulsa | Oklahoma | 74136 | — |
| Northwest Research Center | Portland | Oregon | 97202 | — |
| Specialty Physician Associates | Bethlehem | Pennsylvania | 18017 | — |
| Hospital at the University of PA | Philadelphia | Pennsylvania | 19104 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| National Allergy and Asthma Research | North Charleston | South Carolina | 29420 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| University of TX Health Science Ctr at Houston | Houston | Texas | 77030 | — |
| STAAMP Research, LLC | San Antonio | Texas | 78229 | — |
| Intermountain Ear, Nose & Throat | Salt Lake City | Utah | 84102 | — |
| Chrysallis Clinical Research | St. George | Utah | 84790 | — |
| Eastern Virginia Medical School | Norfolk | Virginia | 23507 | — |
| Bellingham Asthma, Allergy & Immunology Clinic | Bellingham | Washington | 98225 | — |
| Spokane ENT | Spokane Valley | Washington | 99201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 46 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03781804, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 28, 2024 · Synced Jul 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03781804 live on ClinicalTrials.gov.