Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps
Public ClinicalTrials.gov record NCT03781804. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A 24-Week Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study Evaluating the Efficacy and Safety of Intranasal Administration of 186 and 372 μg of OPN-375 Twice a Day (BID) in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a 24-week randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate the efficacy and safety of intranasal administration of 186 and 372 μg twice daily (BID) of OPN-375 in subjects with chronic rhinosinusitis (CS) with or without nasal polyps.
Study identification
- NCT ID
- NCT03781804
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 332 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 27, 2018 (Actual)
- Primary completion
- Jan 19, 2022 (Actual)
- Completion
- Jan 19, 2022 (Actual)
- Last update posted
- May 29, 2024
2018 – 2022
United States locations
- U.S. sites
- 46
- U.S. states
- 26
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AZ Allergy & Immunology Research | Gilbert | Arizona | 85234 | — |
| Kern Research | Bakersfield | California | 93301 | — |
| Sacramento Ear, Nose & Throat Surgical and Medical Group Inc | Folsom | California | 95630 | — |
| Allergy & Asthma Specialists Medical Group | Huntington Beach | California | 92647 | — |
| Jonathan Corren, MD, Clinical Research Division | Los Angeles | California | 90025 | — |
| Sacramento Ear, Nose & Throat | Roseville | California | 95661 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| Allergy and Asthma Associates of Santa Clara Valley | San Jose | California | 95117 | — |
| Breathe Clear Institute | Torrance | California | 90503 | — |
| Allergy & Asthma Clinical Research | Walnut Creek | California | 94598 | — |
| Colorado ENT & Allergy | Colorado Springs | Colorado | 80909 | — |
| Yale School of Medicine Section of Otolaryngology | New Haven | Connecticut | 06519 | — |
| Emory University MOT | Atlanta | Georgia | 30308 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| The University of Chicago | Chicago | Illinois | 60637 | — |
| Midwest Allergy Sinus Asthma | Normal | Illinois | 61761 | — |
| Advanced ENT and Allergy | New Albany | Indiana | 47150 | — |
| Iowa Head & Neck | Des Moines | Iowa | 50312-3505 | — |
| Kentuckiana Ear Nose & Throat | Louisville | Kentucky | 40205 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| John Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Ear, Nose and Throat Associates at Greater Baltimore Medical Center | Towson | Maryland | 21204 | — |
| St. Cloud Ear, Nose & Throat | Saint Cloud | Minnesota | 56303 | — |
| University of Missouri, Dept of Otorlaryngology | Columbia | Missouri | 65212 | — |
| Asthma, Allergy, and Immunology Associates, PC | Lincoln | Nebraska | 68505 | — |
| Atlantic Research Center | Ocean City | New Jersey | 07712 | — |
| ENT and Allergy Associates | New Hyde Park | New York | 11042 | — |
| Mount Sinai Downtown Union Square | New York | New York | 10003 | — |
| Madison ENT and Facial Plastic Surgery | New York | New York | 10016 | — |
| Allergy Asthma & Immunology Relief of Charlotte | Charlotte | North Carolina | 28204 | — |
| Allergy Asthma & Clinical Research Center | Oklahoma City | Oklahoma | 73120 | — |
| Vital Prospects Clinical Research Institute, P.C. | Tulsa | Oklahoma | 74136 | — |
| Northwest Research Center | Portland | Oregon | 97202 | — |
| Specialty Physician Associates | Bethlehem | Pennsylvania | 18017 | — |
| Hospital at the University of PA | Philadelphia | Pennsylvania | 19104 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| National Allergy and Asthma Research | North Charleston | South Carolina | 29420 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| University of TX Health Science Ctr at Houston | Houston | Texas | 77030 | — |
| STAAMP Research, LLC | San Antonio | Texas | 78229 | — |
| Intermountain Ear, Nose & Throat | Salt Lake City | Utah | 84102 | — |
| Chrysallis Clinical Research | St. George | Utah | 84790 | — |
| Eastern Virginia Medical School | Norfolk | Virginia | 23507 | — |
| Bellingham Asthma, Allergy & Immunology Clinic | Bellingham | Washington | 98225 | — |
| Spokane ENT | Spokane Valley | Washington | 99201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 46 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03781804, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 29, 2024 · Synced Nov 9, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03781804 live on ClinicalTrials.gov.